Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective

Autores
Fisch, Samantha C.; Gimeno, Maria Laura; Phan, Julia D.; Simerman, Ariel A.; Dumesic, Daniel A.; Perone, Marcelo Javier; Chazenbalk, Gregorio D.
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers. Muse cells differentiate into cells representative of all three germ cell layers both spontaneously and under media-specific induction. In contrast to embryonic stem and induced pluripotent stem cells, Muse cells exhibit low telomerase activity, a normal karyotype, and do not undergo tumorigenesis once implanted in SCID mice. Muse cells efficiently home into damaged tissues and differentiate into specific cells leading to tissue regeneration and functional recovery as described in different animal disease models (i.e., fulminant hepatitis, muscle degeneration, skin ulcers, liver cirrhosis, cerebral stroke, vitiligo, and focal segmental glomerulosclerosis). Circulating Muse cells have been detected in peripheral blood, with higher levels present in stroke patients during the acute phase. Furthermore, Muse cells have inherent immunomodulatory properties, which could contribute to tissue generation and functional repair in vivo. Genetic studies in Muse cells indicate a highly conserved cellular mechanism as seen in more primitive organisms (yeast, Saccharomyces cerevisiae, Caenorhabditis elegans, chlamydomonas, Torpedo californica, drosophila, etc.) in response to cellular stress and acute injury. This review details the molecular and cellular properties of Muse cells as well as their capacity for tissue repair and functional recovery, highlighting their potential for clinical application in regenerative medicine.
Fil: Fisch, Samantha C.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Gimeno, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Phan, Julia D.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Simerman, Ariel A.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Dumesic, Daniel A.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Chazenbalk, Gregorio D.. University of California at Los Angeles. School of Medicine; Estados Unidos
Materia
ADULT PLURIPOTENT STEM CELLS
CELLULAR STRESS
HIGH HOMING CAPACITY
MUSE CELLS
NONTUMORIGENIC
QUIESCENCE
REGENERATIVE MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/51042
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/51042
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospectiveFisch, Samantha C.Gimeno, Maria LauraPhan, Julia D.Simerman, Ariel A.Dumesic, Daniel A.Perone, Marcelo JavierChazenbalk, Gregorio D.ADULT PLURIPOTENT STEM CELLSCELLULAR STRESSHIGH HOMING CAPACITYMUSE CELLSNONTUMORIGENICQUIESCENCEREGENERATIVE MEDICINEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers. Muse cells differentiate into cells representative of all three germ cell layers both spontaneously and under media-specific induction. In contrast to embryonic stem and induced pluripotent stem cells, Muse cells exhibit low telomerase activity, a normal karyotype, and do not undergo tumorigenesis once implanted in SCID mice. Muse cells efficiently home into damaged tissues and differentiate into specific cells leading to tissue regeneration and functional recovery as described in different animal disease models (i.e., fulminant hepatitis, muscle degeneration, skin ulcers, liver cirrhosis, cerebral stroke, vitiligo, and focal segmental glomerulosclerosis). Circulating Muse cells have been detected in peripheral blood, with higher levels present in stroke patients during the acute phase. Furthermore, Muse cells have inherent immunomodulatory properties, which could contribute to tissue generation and functional repair in vivo. Genetic studies in Muse cells indicate a highly conserved cellular mechanism as seen in more primitive organisms (yeast, Saccharomyces cerevisiae, Caenorhabditis elegans, chlamydomonas, Torpedo californica, drosophila, etc.) in response to cellular stress and acute injury. This review details the molecular and cellular properties of Muse cells as well as their capacity for tissue repair and functional recovery, highlighting their potential for clinical application in regenerative medicine.Fil: Fisch, Samantha C.. University of California at Los Angeles. School of Medicine; Estados UnidosFil: Gimeno, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Phan, Julia D.. University of California at Los Angeles. School of Medicine; Estados UnidosFil: Simerman, Ariel A.. University of California at Los Angeles. School of Medicine; Estados UnidosFil: Dumesic, Daniel A.. University of California at Los Angeles. School of Medicine; Estados UnidosFil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; ArgentinaFil: Chazenbalk, Gregorio D.. University of California at Los Angeles. School of Medicine; Estados UnidosBioMed Central2017-10-18info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/51042Fisch, Samantha C.; Gimeno, Maria Laura; Phan, Julia D.; Simerman, Ariel A.; Dumesic, Daniel A.; et al.; Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective; BioMed Central; Stem Cell Research & Therapy; 8; 1; 18-10-2017; 2271757-6512CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s13287-017-0674-3info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29041955info:eu-repo/semantics/altIdentifier/url/https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0674-3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:53Zoai:ri.conicet.gov.ar:11336/51042instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:53.587CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
title Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
spellingShingle Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
Fisch, Samantha C.
ADULT PLURIPOTENT STEM CELLS
CELLULAR STRESS
HIGH HOMING CAPACITY
MUSE CELLS
NONTUMORIGENIC
QUIESCENCE
REGENERATIVE MEDICINE
title_short Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
title_full Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
title_fullStr Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
title_full_unstemmed Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
title_sort Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective
dc.creator.none.fl_str_mv Fisch, Samantha C.
Gimeno, Maria Laura
Phan, Julia D.
Simerman, Ariel A.
Dumesic, Daniel A.
Perone, Marcelo Javier
Chazenbalk, Gregorio D.
author Fisch, Samantha C.
author_facet Fisch, Samantha C.
Gimeno, Maria Laura
Phan, Julia D.
Simerman, Ariel A.
Dumesic, Daniel A.
Perone, Marcelo Javier
Chazenbalk, Gregorio D.
author_role author
author2 Gimeno, Maria Laura
Phan, Julia D.
Simerman, Ariel A.
Dumesic, Daniel A.
Perone, Marcelo Javier
Chazenbalk, Gregorio D.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv ADULT PLURIPOTENT STEM CELLS
CELLULAR STRESS
HIGH HOMING CAPACITY
MUSE CELLS
NONTUMORIGENIC
QUIESCENCE
REGENERATIVE MEDICINE
topic ADULT PLURIPOTENT STEM CELLS
CELLULAR STRESS
HIGH HOMING CAPACITY
MUSE CELLS
NONTUMORIGENIC
QUIESCENCE
REGENERATIVE MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers. Muse cells differentiate into cells representative of all three germ cell layers both spontaneously and under media-specific induction. In contrast to embryonic stem and induced pluripotent stem cells, Muse cells exhibit low telomerase activity, a normal karyotype, and do not undergo tumorigenesis once implanted in SCID mice. Muse cells efficiently home into damaged tissues and differentiate into specific cells leading to tissue regeneration and functional recovery as described in different animal disease models (i.e., fulminant hepatitis, muscle degeneration, skin ulcers, liver cirrhosis, cerebral stroke, vitiligo, and focal segmental glomerulosclerosis). Circulating Muse cells have been detected in peripheral blood, with higher levels present in stroke patients during the acute phase. Furthermore, Muse cells have inherent immunomodulatory properties, which could contribute to tissue generation and functional repair in vivo. Genetic studies in Muse cells indicate a highly conserved cellular mechanism as seen in more primitive organisms (yeast, Saccharomyces cerevisiae, Caenorhabditis elegans, chlamydomonas, Torpedo californica, drosophila, etc.) in response to cellular stress and acute injury. This review details the molecular and cellular properties of Muse cells as well as their capacity for tissue repair and functional recovery, highlighting their potential for clinical application in regenerative medicine.
Fil: Fisch, Samantha C.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Gimeno, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Phan, Julia D.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Simerman, Ariel A.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Dumesic, Daniel A.. University of California at Los Angeles. School of Medicine; Estados Unidos
Fil: Perone, Marcelo Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina
Fil: Chazenbalk, Gregorio D.. University of California at Los Angeles. School of Medicine; Estados Unidos
description Multilineage differentiating stress enduring (Muse) cells, discovered in the spring of 2010 at Tohoku University in Sendai, Japan, were quickly recognized by scientists as a possible source of pluripotent cells naturally present within mesenchymal tissues. Muse cells normally exist in a quiescent state, singularly activated by severe cellular stress in vitro and in vivo. Muse cells have the capacity for self-renewal while maintaining pluripotent cell characteristics indicated by the expression of pluripotent stem cell markers. Muse cells differentiate into cells representative of all three germ cell layers both spontaneously and under media-specific induction. In contrast to embryonic stem and induced pluripotent stem cells, Muse cells exhibit low telomerase activity, a normal karyotype, and do not undergo tumorigenesis once implanted in SCID mice. Muse cells efficiently home into damaged tissues and differentiate into specific cells leading to tissue regeneration and functional recovery as described in different animal disease models (i.e., fulminant hepatitis, muscle degeneration, skin ulcers, liver cirrhosis, cerebral stroke, vitiligo, and focal segmental glomerulosclerosis). Circulating Muse cells have been detected in peripheral blood, with higher levels present in stroke patients during the acute phase. Furthermore, Muse cells have inherent immunomodulatory properties, which could contribute to tissue generation and functional repair in vivo. Genetic studies in Muse cells indicate a highly conserved cellular mechanism as seen in more primitive organisms (yeast, Saccharomyces cerevisiae, Caenorhabditis elegans, chlamydomonas, Torpedo californica, drosophila, etc.) in response to cellular stress and acute injury. This review details the molecular and cellular properties of Muse cells as well as their capacity for tissue repair and functional recovery, highlighting their potential for clinical application in regenerative medicine.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-18
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/51042
Fisch, Samantha C.; Gimeno, Maria Laura; Phan, Julia D.; Simerman, Ariel A.; Dumesic, Daniel A.; et al.; Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective; BioMed Central; Stem Cell Research & Therapy; 8; 1; 18-10-2017; 227
1757-6512
CONICET Digital
CONICET
url http://hdl.handle.net/11336/51042
identifier_str_mv Fisch, Samantha C.; Gimeno, Maria Laura; Phan, Julia D.; Simerman, Ariel A.; Dumesic, Daniel A.; et al.; Pluripotent nontumorigenic multilineage differentiating stress enduring cells (Muse cells): a seven-year retrospective; BioMed Central; Stem Cell Research & Therapy; 8; 1; 18-10-2017; 227
1757-6512
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s13287-017-0674-3
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pubmed/29041955
info:eu-repo/semantics/altIdentifier/url/https://stemcellres.biomedcentral.com/articles/10.1186/s13287-017-0674-3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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