Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells

Autores
Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.
Fil: Luzzani, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Miriuka, Santiago Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Materia
Pluripotent Stem Cells
Embryonic Stem Cells
Cell Reprogramming
Mesenchymal Stem Cells
Mesenchymal Stromal Cells
Differentiation
Pluripotent-Derived Mesenchymal Stem Cells
Ips-Derived Mesenchymal Stem Cells
Epithelial-To-Mesenchymal Transition
Emt
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/40685
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem CellsLuzzani, Carlos DanielMiriuka, Santiago GabrielPluripotent Stem CellsEmbryonic Stem CellsCell ReprogrammingMesenchymal Stem CellsMesenchymal Stromal CellsDifferentiationPluripotent-Derived Mesenchymal Stem CellsIps-Derived Mesenchymal Stem CellsEpithelial-To-Mesenchymal TransitionEmthttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.Fil: Luzzani, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Miriuka, Santiago Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaSpringer Heidelberg2017-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40685Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells; Springer Heidelberg; Stem Cell Reviews And Reports; 13; 1; 1-2017; 68-781550-8943CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-016-9695-zinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12015-016-9695-zinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:47:02Zoai:ri.conicet.gov.ar:11336/40685instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:47:02.388CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
title Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
spellingShingle Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
Luzzani, Carlos Daniel
Pluripotent Stem Cells
Embryonic Stem Cells
Cell Reprogramming
Mesenchymal Stem Cells
Mesenchymal Stromal Cells
Differentiation
Pluripotent-Derived Mesenchymal Stem Cells
Ips-Derived Mesenchymal Stem Cells
Epithelial-To-Mesenchymal Transition
Emt
title_short Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
title_full Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
title_fullStr Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
title_full_unstemmed Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
title_sort Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells
dc.creator.none.fl_str_mv Luzzani, Carlos Daniel
Miriuka, Santiago Gabriel
author Luzzani, Carlos Daniel
author_facet Luzzani, Carlos Daniel
Miriuka, Santiago Gabriel
author_role author
author2 Miriuka, Santiago Gabriel
author2_role author
dc.subject.none.fl_str_mv Pluripotent Stem Cells
Embryonic Stem Cells
Cell Reprogramming
Mesenchymal Stem Cells
Mesenchymal Stromal Cells
Differentiation
Pluripotent-Derived Mesenchymal Stem Cells
Ips-Derived Mesenchymal Stem Cells
Epithelial-To-Mesenchymal Transition
Emt
topic Pluripotent Stem Cells
Embryonic Stem Cells
Cell Reprogramming
Mesenchymal Stem Cells
Mesenchymal Stromal Cells
Differentiation
Pluripotent-Derived Mesenchymal Stem Cells
Ips-Derived Mesenchymal Stem Cells
Epithelial-To-Mesenchymal Transition
Emt
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.
Fil: Luzzani, Carlos Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Miriuka, Santiago Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Laboratorio de Investigaciones en Neurociencias Aplicadas; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
description Mesenchymal stem cells (MSC) have been extensively studied over the past years for the treatment of different diseases. Most of the ongoing clinical trials currently involve the use of MSC derived from adult tissues. This source may have some limitations, particularly with therapies that may require extensive and repetitive cell dosage. However, nowadays, there is a staggering growth in literature on a new source of MSC. There is now increasing evidence about the mesenchymal differentiation from pluripotent stem cell (PSC). Here, we summarize the current knowledge of pluripotent-derived mesenchymal stem cells (PD-MSC). We present a historical perspective on the subject, and then discuss some critical questions that remain unanswered.
publishDate 2017
dc.date.none.fl_str_mv 2017-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/40685
Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells; Springer Heidelberg; Stem Cell Reviews And Reports; 13; 1; 1-2017; 68-78
1550-8943
CONICET Digital
CONICET
url http://hdl.handle.net/11336/40685
identifier_str_mv Luzzani, Carlos Daniel; Miriuka, Santiago Gabriel; Pluripotent Stem Cells as a Robust Source of Mesenchymal Stem Cells; Springer Heidelberg; Stem Cell Reviews And Reports; 13; 1; 1-2017; 68-78
1550-8943
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s12015-016-9695-z
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs12015-016-9695-z
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer Heidelberg
publisher.none.fl_str_mv Springer Heidelberg
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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