A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues

Autores
Simerman, Ariel A.; Perone, Marcelo Javier; Gimeno, Maria Laura; Dumesic, Daniel A.; Chazenblak, Gregorio D.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of 10 stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and 15 exciting avenue of exploration for the potential treatment of various human diseases. Areas covered: This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known 20 of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discussing both mesenchymal and various reported populations of pluripotent stem cells, and finally, delving into Muse cells and what sets them apart from their contemporaries. Expert opinion: Muse cells derived from adipose tissue (Muse-AT) are 25 efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-ATcells and their potential impact on the field of regenerative medicine and cell therapy.
Fil: Simerman, Ariel A.. University of California; Estados Unidos
Fil: Perone, Marcelo Javier. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina
Fil: Gimeno, Maria Laura. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina
Fil: Dumesic, Daniel A.. University of California; Estados Unidos
Fil: Chazenblak, Gregorio D.. University of California; Estados Unidos
Materia
HUMAN PLURIPOTENT STEM CELLS
MUSE CELLS
NONTUMORIGENIC
REGENERATIVE MEDICINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/12308
Acceder
id CONICETDig_6e1af43b1f4c5094e2351ab904957637
oai_identifier_str oai:ri.conicet.gov.ar:11336/12308
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissuesSimerman, Ariel A.Perone, Marcelo JavierGimeno, Maria LauraDumesic, Daniel A.Chazenblak, Gregorio D.HUMAN PLURIPOTENT STEM CELLSMUSE CELLSNONTUMORIGENICREGENERATIVE MEDICINEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of 10 stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and 15 exciting avenue of exploration for the potential treatment of various human diseases. Areas covered: This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known 20 of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discussing both mesenchymal and various reported populations of pluripotent stem cells, and finally, delving into Muse cells and what sets them apart from their contemporaries. Expert opinion: Muse cells derived from adipose tissue (Muse-AT) are 25 efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-ATcells and their potential impact on the field of regenerative medicine and cell therapy.Fil: Simerman, Ariel A.. University of California; Estados UnidosFil: Perone, Marcelo Javier. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; ArgentinaFil: Gimeno, Maria Laura. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; ArgentinaFil: Dumesic, Daniel A.. University of California; Estados UnidosFil: Chazenblak, Gregorio D.. University of California; Estados UnidosInforma Healthcare2014-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/12308Simerman, Ariel A.; Perone, Marcelo Javier; Gimeno, Maria Laura; Dumesic, Daniel A.; Chazenblak, Gregorio D.; A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues; Informa Healthcare; Expert Opinion On Biological Therapy; 14; 7; 3-2014; 917-9291471-2598enginfo:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14712598.2014.900538?journalCode=iebt20info:eu-repo/semantics/altIdentifier/doi/10.1517/14712598.2014.900538info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100978/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:35Zoai:ri.conicet.gov.ar:11336/12308instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:35.278CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
title A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
spellingShingle A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
Simerman, Ariel A.
HUMAN PLURIPOTENT STEM CELLS
MUSE CELLS
NONTUMORIGENIC
REGENERATIVE MEDICINE
title_short A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
title_full A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
title_fullStr A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
title_full_unstemmed A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
title_sort A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues
dc.creator.none.fl_str_mv Simerman, Ariel A.
Perone, Marcelo Javier
Gimeno, Maria Laura
Dumesic, Daniel A.
Chazenblak, Gregorio D.
author Simerman, Ariel A.
author_facet Simerman, Ariel A.
Perone, Marcelo Javier
Gimeno, Maria Laura
Dumesic, Daniel A.
Chazenblak, Gregorio D.
author_role author
author2 Perone, Marcelo Javier
Gimeno, Maria Laura
Dumesic, Daniel A.
Chazenblak, Gregorio D.
author2_role author
author
author
author
dc.subject.none.fl_str_mv HUMAN PLURIPOTENT STEM CELLS
MUSE CELLS
NONTUMORIGENIC
REGENERATIVE MEDICINE
topic HUMAN PLURIPOTENT STEM CELLS
MUSE CELLS
NONTUMORIGENIC
REGENERATIVE MEDICINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of 10 stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and 15 exciting avenue of exploration for the potential treatment of various human diseases. Areas covered: This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known 20 of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discussing both mesenchymal and various reported populations of pluripotent stem cells, and finally, delving into Muse cells and what sets them apart from their contemporaries. Expert opinion: Muse cells derived from adipose tissue (Muse-AT) are 25 efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-ATcells and their potential impact on the field of regenerative medicine and cell therapy.
Fil: Simerman, Ariel A.. University of California; Estados Unidos
Fil: Perone, Marcelo Javier. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina
Fil: Gimeno, Maria Laura. University of California; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires; Argentina
Fil: Dumesic, Daniel A.. University of California; Estados Unidos
Fil: Chazenblak, Gregorio D.. University of California; Estados Unidos
description Embryonic stem cells and induced pluripotent stem cells have emerged as the gold standard of pluripotent stem cells and the class of 10 stem cell with the highest potential for contribution to regenerative and therapeutic application; however, their translational use is often impeded by teratoma formation, commonly associated with pluripotency. We discuss a population of nontumorigenic pluripotent stem cells, termed Multilineage Differentiating Stress Enduring (Muse) cells, which offer an innovative and 15 exciting avenue of exploration for the potential treatment of various human diseases. Areas covered: This review discusses the origin of Muse cells, describes in detail their various unique characteristics, and considers future avenues of their application and investigation with respect to what is currently known 20 of adult pluripotent stem cells in scientific literature. We begin by defining cell potency, then discussing both mesenchymal and various reported populations of pluripotent stem cells, and finally, delving into Muse cells and what sets them apart from their contemporaries. Expert opinion: Muse cells derived from adipose tissue (Muse-AT) are 25 efficiently, routinely and painlessly isolated from human lipoaspirate material, exhibit tripoblastic differentiation both spontaneously and under media-specific induction, and do not form teratomas. We describe qualities specific to Muse-ATcells and their potential impact on the field of regenerative medicine and cell therapy.
publishDate 2014
dc.date.none.fl_str_mv 2014-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/12308
Simerman, Ariel A.; Perone, Marcelo Javier; Gimeno, Maria Laura; Dumesic, Daniel A.; Chazenblak, Gregorio D.; A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues; Informa Healthcare; Expert Opinion On Biological Therapy; 14; 7; 3-2014; 917-929
1471-2598
url http://hdl.handle.net/11336/12308
identifier_str_mv Simerman, Ariel A.; Perone, Marcelo Javier; Gimeno, Maria Laura; Dumesic, Daniel A.; Chazenblak, Gregorio D.; A Mystery Unraveled: Non-tumorigenic pluripotent stem cells in human adult tissues; Informa Healthcare; Expert Opinion On Biological Therapy; 14; 7; 3-2014; 917-929
1471-2598
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.1517/14712598.2014.900538?journalCode=iebt20
info:eu-repo/semantics/altIdentifier/doi/10.1517/14712598.2014.900538
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100978/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Informa Healthcare
publisher.none.fl_str_mv Informa Healthcare
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614148822925312
score 13.070432

Publicaciones similares