Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes

Autores
Castro, Mariana Nair; Vigo, Daniel Eduardo; Gustafson, D. R.; Vila Pérez, I.; Massaro, P.; García, C.; Nemeroff, Charles B.; Guinjoan, Salvador Martín; Ladrón de Guevara, Maria Soledad
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To characterize the influence of changes in depression symptoms severity six months after an acute coronary syndrome (ACS) on the circadian pattern of cardiac autonomic activity, a known independent predictor of adverse outcomes. Methods: One hundred two patients consecutively admitted to the coronary care unit (CCU) with an ACS were evaluated with a clinical interview (including a psychiatric evaluation for depression), the 21-item Hamilton Depression Scale (HAM-D) for symptom severity and a 24 h recording of heart rate variability (HRV) at admission and six months post-discharge from the CCU. HRV was measured during wake and sleep (23.00 h–07.00 h) with a fast Fourier transform algorithm. We obtained meanRR (mRR), low-frequency HRV (LF) influenced by both sympathetic and parasympathetic activity, high-frequency HRV (HF) determined solely by parasympathetic activity, and LF/HF ratio as a measure of the sympatho-vagal balance onto the heart (LF/HF). Results: Upon admission to the CCU, major depression was present in 44% of subjects. Depression was associated with shorter mRR (higher heart rate), during sleep (p < 0.05). At six months, depression was associated with shorter mRR during wake (p < 0.05) and sleep (p < 0.01), decreased mRR sleep-wake difference (p < 0.05), and lower LF both during wake (p < 0.05) and sleep (p < 0.05). LF and HF changes were related to HAM-D changes 6 months after the index episode. Conclusions: Depression influenced circadian rhythm of autonomic activity, most notably upon 6-month follow up. Changes in depressive symptom severity after a 6-month observation period were related to changes in HRV known to adversely affect coronary prognosis.
Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Gustafson, D. R.. University of New York; Estados Unidos. University of Gothenburg; Suecia
Fil: Vila Pérez, I.. Hospital Vall d’Hebron; España
Fil: Massaro, P.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ladrón de Guevara, Maria Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Hospital Vall d’Hebron; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Depression
Acute Coronary Syndrome
Circadian Rhythm
Autonomic Nervous System
Heart Rate Variability
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41183
Acceder
id CONICETDig_aee27fae8910b1bd253920f8550ba020
oai_identifier_str oai:ri.conicet.gov.ar:11336/41183
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromesCastro, Mariana NairVigo, Daniel EduardoGustafson, D. R.Vila Pérez, I.Massaro, P.García, C.Nemeroff, Charles B.Guinjoan, Salvador MartínLadrón de Guevara, Maria SoledadDepressionAcute Coronary SyndromeCircadian RhythmAutonomic Nervous SystemHeart Rate Variabilityhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objectives: To characterize the influence of changes in depression symptoms severity six months after an acute coronary syndrome (ACS) on the circadian pattern of cardiac autonomic activity, a known independent predictor of adverse outcomes. Methods: One hundred two patients consecutively admitted to the coronary care unit (CCU) with an ACS were evaluated with a clinical interview (including a psychiatric evaluation for depression), the 21-item Hamilton Depression Scale (HAM-D) for symptom severity and a 24 h recording of heart rate variability (HRV) at admission and six months post-discharge from the CCU. HRV was measured during wake and sleep (23.00 h–07.00 h) with a fast Fourier transform algorithm. We obtained meanRR (mRR), low-frequency HRV (LF) influenced by both sympathetic and parasympathetic activity, high-frequency HRV (HF) determined solely by parasympathetic activity, and LF/HF ratio as a measure of the sympatho-vagal balance onto the heart (LF/HF). Results: Upon admission to the CCU, major depression was present in 44% of subjects. Depression was associated with shorter mRR (higher heart rate), during sleep (p < 0.05). At six months, depression was associated with shorter mRR during wake (p < 0.05) and sleep (p < 0.01), decreased mRR sleep-wake difference (p < 0.05), and lower LF both during wake (p < 0.05) and sleep (p < 0.05). LF and HF changes were related to HAM-D changes 6 months after the index episode. Conclusions: Depression influenced circadian rhythm of autonomic activity, most notably upon 6-month follow up. Changes in depressive symptom severity after a 6-month observation period were related to changes in HRV known to adversely affect coronary prognosis.Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; ArgentinaFil: Gustafson, D. R.. University of New York; Estados Unidos. University of Gothenburg; SueciaFil: Vila Pérez, I.. Hospital Vall d’Hebron; EspañaFil: Massaro, P.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; ArgentinaFil: Nemeroff, Charles B.. University of Miami; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ladrón de Guevara, Maria Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Hospital Vall d’Hebron; España. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaElsevier2017-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41183Castro, Mariana Nair; Vigo, Daniel Eduardo; Gustafson, D. R.; Vila Pérez, I.; Massaro, P.; et al.; Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes; Elsevier; Personalized Medicine in Psychiatry; 4-6; 8-2017; 13-182468-1717CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.pmip.2017.06.001info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468171717300157info:eu-repo/semantics/altIdentifier/url/http://www.personalizedmedpsych.com/article/S2468-1717(17)30015-7/fulltextinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:41Zoai:ri.conicet.gov.ar:11336/41183instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:42.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
title Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
spellingShingle Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
Castro, Mariana Nair
Depression
Acute Coronary Syndrome
Circadian Rhythm
Autonomic Nervous System
Heart Rate Variability
title_short Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
title_full Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
title_fullStr Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
title_full_unstemmed Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
title_sort Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes
dc.creator.none.fl_str_mv Castro, Mariana Nair
Vigo, Daniel Eduardo
Gustafson, D. R.
Vila Pérez, I.
Massaro, P.
García, C.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Ladrón de Guevara, Maria Soledad
author Castro, Mariana Nair
author_facet Castro, Mariana Nair
Vigo, Daniel Eduardo
Gustafson, D. R.
Vila Pérez, I.
Massaro, P.
García, C.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Ladrón de Guevara, Maria Soledad
author_role author
author2 Vigo, Daniel Eduardo
Gustafson, D. R.
Vila Pérez, I.
Massaro, P.
García, C.
Nemeroff, Charles B.
Guinjoan, Salvador Martín
Ladrón de Guevara, Maria Soledad
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Depression
Acute Coronary Syndrome
Circadian Rhythm
Autonomic Nervous System
Heart Rate Variability
topic Depression
Acute Coronary Syndrome
Circadian Rhythm
Autonomic Nervous System
Heart Rate Variability
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: To characterize the influence of changes in depression symptoms severity six months after an acute coronary syndrome (ACS) on the circadian pattern of cardiac autonomic activity, a known independent predictor of adverse outcomes. Methods: One hundred two patients consecutively admitted to the coronary care unit (CCU) with an ACS were evaluated with a clinical interview (including a psychiatric evaluation for depression), the 21-item Hamilton Depression Scale (HAM-D) for symptom severity and a 24 h recording of heart rate variability (HRV) at admission and six months post-discharge from the CCU. HRV was measured during wake and sleep (23.00 h–07.00 h) with a fast Fourier transform algorithm. We obtained meanRR (mRR), low-frequency HRV (LF) influenced by both sympathetic and parasympathetic activity, high-frequency HRV (HF) determined solely by parasympathetic activity, and LF/HF ratio as a measure of the sympatho-vagal balance onto the heart (LF/HF). Results: Upon admission to the CCU, major depression was present in 44% of subjects. Depression was associated with shorter mRR (higher heart rate), during sleep (p < 0.05). At six months, depression was associated with shorter mRR during wake (p < 0.05) and sleep (p < 0.01), decreased mRR sleep-wake difference (p < 0.05), and lower LF both during wake (p < 0.05) and sleep (p < 0.05). LF and HF changes were related to HAM-D changes 6 months after the index episode. Conclusions: Depression influenced circadian rhythm of autonomic activity, most notably upon 6-month follow up. Changes in depressive symptom severity after a 6-month observation period were related to changes in HRV known to adversely affect coronary prognosis.
Fil: Castro, Mariana Nair. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Vigo, Daniel Eduardo. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Instituto de Investigaciones Biomédicas. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas; Argentina
Fil: Gustafson, D. R.. University of New York; Estados Unidos. University of Gothenburg; Suecia
Fil: Vila Pérez, I.. Hospital Vall d’Hebron; España
Fil: Massaro, P.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: García, C.. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina
Fil: Nemeroff, Charles B.. University of Miami; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Ladrón de Guevara, Maria Soledad. Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia; Argentina. Hospital Vall d’Hebron; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Objectives: To characterize the influence of changes in depression symptoms severity six months after an acute coronary syndrome (ACS) on the circadian pattern of cardiac autonomic activity, a known independent predictor of adverse outcomes. Methods: One hundred two patients consecutively admitted to the coronary care unit (CCU) with an ACS were evaluated with a clinical interview (including a psychiatric evaluation for depression), the 21-item Hamilton Depression Scale (HAM-D) for symptom severity and a 24 h recording of heart rate variability (HRV) at admission and six months post-discharge from the CCU. HRV was measured during wake and sleep (23.00 h–07.00 h) with a fast Fourier transform algorithm. We obtained meanRR (mRR), low-frequency HRV (LF) influenced by both sympathetic and parasympathetic activity, high-frequency HRV (HF) determined solely by parasympathetic activity, and LF/HF ratio as a measure of the sympatho-vagal balance onto the heart (LF/HF). Results: Upon admission to the CCU, major depression was present in 44% of subjects. Depression was associated with shorter mRR (higher heart rate), during sleep (p < 0.05). At six months, depression was associated with shorter mRR during wake (p < 0.05) and sleep (p < 0.01), decreased mRR sleep-wake difference (p < 0.05), and lower LF both during wake (p < 0.05) and sleep (p < 0.05). LF and HF changes were related to HAM-D changes 6 months after the index episode. Conclusions: Depression influenced circadian rhythm of autonomic activity, most notably upon 6-month follow up. Changes in depressive symptom severity after a 6-month observation period were related to changes in HRV known to adversely affect coronary prognosis.
publishDate 2017
dc.date.none.fl_str_mv 2017-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41183
Castro, Mariana Nair; Vigo, Daniel Eduardo; Gustafson, D. R.; Vila Pérez, I.; Massaro, P.; et al.; Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes; Elsevier; Personalized Medicine in Psychiatry; 4-6; 8-2017; 13-18
2468-1717
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41183
identifier_str_mv Castro, Mariana Nair; Vigo, Daniel Eduardo; Gustafson, D. R.; Vila Pérez, I.; Massaro, P.; et al.; Acute and six-month depression-related abnormalities in the sleep-wake rhythm of cardiac autonomic activity in survivors of acute coronary syndromes; Elsevier; Personalized Medicine in Psychiatry; 4-6; 8-2017; 13-18
2468-1717
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pmip.2017.06.001
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2468171717300157
info:eu-repo/semantics/altIdentifier/url/http://www.personalizedmedpsych.com/article/S2468-1717(17)30015-7/fulltext
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269048217272320
score 13.13397

Publicaciones similares