Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease...

Autores
Carbajales, Justo; Principato, Mario Bruno; Salamé Rodriguez, Michael Fuad; Duarte, Alejandra Beatriz; Tomatti, Alejandro; Paolucci, A. G.; Gonzalez, P. E.; Bragagnolo, J. C.; Ciampi, Natalia; Von Wulffen, María Alejandra; Castilla, Rocio Soledad
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Early B-cell factor 1 (EBF1) gene participates in the development of the central nervous system and is expressed in adipocytesand olfactory neuroepithelium, which is intimately linked with the emotion and reward system in adults. For this reason, it could be linkedto tobacco addictionObjective: The aim of this study was to determine probable association between the EBF1 gene rs4704963 SNP (T>C) with smoking habitsin a population of patients with multiple coronary risk factors (CRF) with and without acute coronary syndromes (ACS).Materials and methods: Between December 2015 and March 2017, 104 consecutive patients with two or more risk factors, with or withoutACS were included. A 10-mL blood sample was collected from all the patients for SNP determination. DNA genotyping was carried out usingthe nested PCR technique and subsequent sequencing.Results: Mean age was 59.1 ± 9.17 years and 59.6% were men. The most common CRF were smoking habits (60.6%) hypertension (56.7%)and diabetes (48.1%).None of the patients had the homozygous T / T haplotype while 17 patients (16.3%) presented the T / C haplotype forheterozygous SNP. Among the 17 patients with the SNP detected, 16 (94.1%) were smokers compared to 54% of smokers in those patientswithout the SNP detected (p = 0.002).In those patients with ACS and smoking habits, the SNP was detected in 21.3% versus 0% in those with ACS and no history of smoking habits(p= 0.029)Conclusion: A significant association was observed between the EBF1 gene rs4704963 SNP (T> C) with smoking habits in patients with ACSand in those with CRF without ACS. Further research including more patients is necessary to confirm these findings in order to customizedecision-making to prevent this addiction and indicate the appropriate treatment when smoking is present.
Fil: Carbajales, Justo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Principato, Mario Bruno. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Salamé Rodriguez, Michael Fuad. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Duarte, Alejandra Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Tomatti, Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Paolucci, A. G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Gonzalez, P. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Bragagnolo, J. C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Ciampi, Natalia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Von Wulffen, María Alejandra. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
CORONARY HEART DESEASE
CORONARY SYNDROMES
HEART DEASESE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/160226
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/160226
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, ArgentinaCarbajales, JustoPrincipato, Mario BrunoSalamé Rodriguez, Michael FuadDuarte, Alejandra BeatrizTomatti, AlejandroPaolucci, A. G.Gonzalez, P. E.Bragagnolo, J. C.Ciampi, NataliaVon Wulffen, María AlejandraCastilla, Rocio SoledadCORONARY HEART DESEASECORONARY SYNDROMESHEART DEASESEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Introduction: Early B-cell factor 1 (EBF1) gene participates in the development of the central nervous system and is expressed in adipocytesand olfactory neuroepithelium, which is intimately linked with the emotion and reward system in adults. For this reason, it could be linkedto tobacco addictionObjective: The aim of this study was to determine probable association between the EBF1 gene rs4704963 SNP (T>C) with smoking habitsin a population of patients with multiple coronary risk factors (CRF) with and without acute coronary syndromes (ACS).Materials and methods: Between December 2015 and March 2017, 104 consecutive patients with two or more risk factors, with or withoutACS were included. A 10-mL blood sample was collected from all the patients for SNP determination. DNA genotyping was carried out usingthe nested PCR technique and subsequent sequencing.Results: Mean age was 59.1 ± 9.17 years and 59.6% were men. The most common CRF were smoking habits (60.6%) hypertension (56.7%)and diabetes (48.1%).None of the patients had the homozygous T / T haplotype while 17 patients (16.3%) presented the T / C haplotype forheterozygous SNP. Among the 17 patients with the SNP detected, 16 (94.1%) were smokers compared to 54% of smokers in those patientswithout the SNP detected (p = 0.002).In those patients with ACS and smoking habits, the SNP was detected in 21.3% versus 0% in those with ACS and no history of smoking habits(p= 0.029)Conclusion: A significant association was observed between the EBF1 gene rs4704963 SNP (T> C) with smoking habits in patients with ACSand in those with CRF without ACS. Further research including more patients is necessary to confirm these findings in order to customizedecision-making to prevent this addiction and indicate the appropriate treatment when smoking is present.Fil: Carbajales, Justo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Principato, Mario Bruno. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Salamé Rodriguez, Michael Fuad. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Duarte, Alejandra Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; ArgentinaFil: Tomatti, Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Paolucci, A. G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Gonzalez, P. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Bragagnolo, J. C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Ciampi, Natalia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Von Wulffen, María Alejandra. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; ArgentinaFil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaAuctores Publishing2019-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/160226Carbajales, Justo; Principato, Mario Bruno; Salamé Rodriguez, Michael Fuad; Duarte, Alejandra Beatriz; Tomatti, Alejandro; et al.; Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina; Auctores Publishing; Clinical Cardiology and Cardiovascular Interventions; 10-2019; 1-52641-0419CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://auctoresonline.org/article/relationship-between-the-single-nucleotide-polymorphism-rs4704963-3E-c29-of-the-early-b-cell-factor-1-gene-and-smoking-in-a-population-with-risk-factors-for-coronary-heart-disease-with-and-without-acuinfo:eu-repo/semantics/altIdentifier/doi/10.31579/2641-0419/018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:07:44Zoai:ri.conicet.gov.ar:11336/160226instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:07:44.866CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
title Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
spellingShingle Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
Carbajales, Justo
CORONARY HEART DESEASE
CORONARY SYNDROMES
HEART DEASESE
title_short Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
title_full Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
title_fullStr Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
title_full_unstemmed Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
title_sort Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina
dc.creator.none.fl_str_mv Carbajales, Justo
Principato, Mario Bruno
Salamé Rodriguez, Michael Fuad
Duarte, Alejandra Beatriz
Tomatti, Alejandro
Paolucci, A. G.
Gonzalez, P. E.
Bragagnolo, J. C.
Ciampi, Natalia
Von Wulffen, María Alejandra
Castilla, Rocio Soledad
author Carbajales, Justo
author_facet Carbajales, Justo
Principato, Mario Bruno
Salamé Rodriguez, Michael Fuad
Duarte, Alejandra Beatriz
Tomatti, Alejandro
Paolucci, A. G.
Gonzalez, P. E.
Bragagnolo, J. C.
Ciampi, Natalia
Von Wulffen, María Alejandra
Castilla, Rocio Soledad
author_role author
author2 Principato, Mario Bruno
Salamé Rodriguez, Michael Fuad
Duarte, Alejandra Beatriz
Tomatti, Alejandro
Paolucci, A. G.
Gonzalez, P. E.
Bragagnolo, J. C.
Ciampi, Natalia
Von Wulffen, María Alejandra
Castilla, Rocio Soledad
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CORONARY HEART DESEASE
CORONARY SYNDROMES
HEART DEASESE
topic CORONARY HEART DESEASE
CORONARY SYNDROMES
HEART DEASESE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Early B-cell factor 1 (EBF1) gene participates in the development of the central nervous system and is expressed in adipocytesand olfactory neuroepithelium, which is intimately linked with the emotion and reward system in adults. For this reason, it could be linkedto tobacco addictionObjective: The aim of this study was to determine probable association between the EBF1 gene rs4704963 SNP (T>C) with smoking habitsin a population of patients with multiple coronary risk factors (CRF) with and without acute coronary syndromes (ACS).Materials and methods: Between December 2015 and March 2017, 104 consecutive patients with two or more risk factors, with or withoutACS were included. A 10-mL blood sample was collected from all the patients for SNP determination. DNA genotyping was carried out usingthe nested PCR technique and subsequent sequencing.Results: Mean age was 59.1 ± 9.17 years and 59.6% were men. The most common CRF were smoking habits (60.6%) hypertension (56.7%)and diabetes (48.1%).None of the patients had the homozygous T / T haplotype while 17 patients (16.3%) presented the T / C haplotype forheterozygous SNP. Among the 17 patients with the SNP detected, 16 (94.1%) were smokers compared to 54% of smokers in those patientswithout the SNP detected (p = 0.002).In those patients with ACS and smoking habits, the SNP was detected in 21.3% versus 0% in those with ACS and no history of smoking habits(p= 0.029)Conclusion: A significant association was observed between the EBF1 gene rs4704963 SNP (T> C) with smoking habits in patients with ACSand in those with CRF without ACS. Further research including more patients is necessary to confirm these findings in order to customizedecision-making to prevent this addiction and indicate the appropriate treatment when smoking is present.
Fil: Carbajales, Justo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Principato, Mario Bruno. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Salamé Rodriguez, Michael Fuad. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Duarte, Alejandra Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Medicina Experimental. Academia Nacional de Medicina de Buenos Aires. Instituto de Medicina Experimental; Argentina
Fil: Tomatti, Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Paolucci, A. G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Gonzalez, P. E.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Bragagnolo, J. C.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Ciampi, Natalia. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Von Wulffen, María Alejandra. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
Fil: Castilla, Rocio Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Introduction: Early B-cell factor 1 (EBF1) gene participates in the development of the central nervous system and is expressed in adipocytesand olfactory neuroepithelium, which is intimately linked with the emotion and reward system in adults. For this reason, it could be linkedto tobacco addictionObjective: The aim of this study was to determine probable association between the EBF1 gene rs4704963 SNP (T>C) with smoking habitsin a population of patients with multiple coronary risk factors (CRF) with and without acute coronary syndromes (ACS).Materials and methods: Between December 2015 and March 2017, 104 consecutive patients with two or more risk factors, with or withoutACS were included. A 10-mL blood sample was collected from all the patients for SNP determination. DNA genotyping was carried out usingthe nested PCR technique and subsequent sequencing.Results: Mean age was 59.1 ± 9.17 years and 59.6% were men. The most common CRF were smoking habits (60.6%) hypertension (56.7%)and diabetes (48.1%).None of the patients had the homozygous T / T haplotype while 17 patients (16.3%) presented the T / C haplotype forheterozygous SNP. Among the 17 patients with the SNP detected, 16 (94.1%) were smokers compared to 54% of smokers in those patientswithout the SNP detected (p = 0.002).In those patients with ACS and smoking habits, the SNP was detected in 21.3% versus 0% in those with ACS and no history of smoking habits(p= 0.029)Conclusion: A significant association was observed between the EBF1 gene rs4704963 SNP (T> C) with smoking habits in patients with ACSand in those with CRF without ACS. Further research including more patients is necessary to confirm these findings in order to customizedecision-making to prevent this addiction and indicate the appropriate treatment when smoking is present.
publishDate 2019
dc.date.none.fl_str_mv 2019-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/160226
Carbajales, Justo; Principato, Mario Bruno; Salamé Rodriguez, Michael Fuad; Duarte, Alejandra Beatriz; Tomatti, Alejandro; et al.; Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina; Auctores Publishing; Clinical Cardiology and Cardiovascular Interventions; 10-2019; 1-5
2641-0419
CONICET Digital
CONICET
url http://hdl.handle.net/11336/160226
identifier_str_mv Carbajales, Justo; Principato, Mario Bruno; Salamé Rodriguez, Michael Fuad; Duarte, Alejandra Beatriz; Tomatti, Alejandro; et al.; Relationship between the single nucleotide polymorphism rs4704963 (T> C) of the Early B-Cell Factor 1 gene and smoking in a population with risk factors for coronary heart disease with and without acute coronary syndromes treated in Buenos Aires City, Argentina; Auctores Publishing; Clinical Cardiology and Cardiovascular Interventions; 10-2019; 1-5
2641-0419
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://auctoresonline.org/article/relationship-between-the-single-nucleotide-polymorphism-rs4704963-3E-c29-of-the-early-b-cell-factor-1-gene-and-smoking-in-a-population-with-risk-factors-for-coronary-heart-disease-with-and-without-acu
info:eu-repo/semantics/altIdentifier/doi/10.31579/2641-0419/018
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Auctores Publishing
publisher.none.fl_str_mv Auctores Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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