Proinflammatory state in obese children

Autores
Luciardi, María Constanza; Carrizo, T. R.; Díaz, E. I.; Aleman, Mariano Nicolás; Bazán, M. C.; Abregu, A. V.
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proinflammatory molecules that favor the development of atherosclerosis. Objective: To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and high sensitivity CRP (hsCRP), in an obese children population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables. Patients and Method: A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables. Results: Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1. Conclusion: Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.
Fil: Luciardi, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Carrizo, T. R.. Universidad Nacional de Tucumán; Argentina
Fil: Díaz, E. I.. Universidad Nacional de Tucumán; Argentina
Fil: Aleman, Mariano Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Bazán, M. C.. Provincia de Tucumán. Ministerio de Salud. Sistema Provincial de Salud. Hospital del Niño Jesús; Argentina
Fil: Abregu, A. V.. Universidad Nacional de Tucumán; Argentina
Materia
Obesity
Subclinical inflam mation
TNF-a
hsPCR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/268109
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/268109
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Proinflammatory state in obese childrenEstado proinflamatorio en niños obesosLuciardi, María ConstanzaCarrizo, T. R.Díaz, E. I.Aleman, Mariano NicolásBazán, M. C.Abregu, A. V.ObesitySubclinical inflam mationTNF-ahsPCRhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proinflammatory molecules that favor the development of atherosclerosis. Objective: To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and high sensitivity CRP (hsCRP), in an obese children population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables. Patients and Method: A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables. Results: Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1. Conclusion: Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.Fil: Luciardi, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; ArgentinaFil: Carrizo, T. R.. Universidad Nacional de Tucumán; ArgentinaFil: Díaz, E. I.. Universidad Nacional de Tucumán; ArgentinaFil: Aleman, Mariano Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Bazán, M. C.. Provincia de Tucumán. Ministerio de Salud. Sistema Provincial de Salud. Hospital del Niño Jesús; ArgentinaFil: Abregu, A. V.. Universidad Nacional de Tucumán; ArgentinaSociedad Chilena de Pediatría2018-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/268109Luciardi, María Constanza; Carrizo, T. R.; Díaz, E. I.; Aleman, Mariano Nicolás; Bazán, M. C.; et al.; Proinflammatory state in obese children; Sociedad Chilena de Pediatría; Revista chilena de pediatría; 3; 2-2018; 346-3510370-41060717-6228CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062018005000501&lng=en&nrm=iso&tlng=eninfo:eu-repo/semantics/altIdentifier/doi/10.4067/S0370-41062018005000501info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:26:53Zoai:ri.conicet.gov.ar:11336/268109instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:26:53.593CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Proinflammatory state in obese children
Estado proinflamatorio en niños obesos
title Proinflammatory state in obese children
spellingShingle Proinflammatory state in obese children
Luciardi, María Constanza
Obesity
Subclinical inflam mation
TNF-a
hsPCR
title_short Proinflammatory state in obese children
title_full Proinflammatory state in obese children
title_fullStr Proinflammatory state in obese children
title_full_unstemmed Proinflammatory state in obese children
title_sort Proinflammatory state in obese children
dc.creator.none.fl_str_mv Luciardi, María Constanza
Carrizo, T. R.
Díaz, E. I.
Aleman, Mariano Nicolás
Bazán, M. C.
Abregu, A. V.
author Luciardi, María Constanza
author_facet Luciardi, María Constanza
Carrizo, T. R.
Díaz, E. I.
Aleman, Mariano Nicolás
Bazán, M. C.
Abregu, A. V.
author_role author
author2 Carrizo, T. R.
Díaz, E. I.
Aleman, Mariano Nicolás
Bazán, M. C.
Abregu, A. V.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Obesity
Subclinical inflam mation
TNF-a
hsPCR
topic Obesity
Subclinical inflam mation
TNF-a
hsPCR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proinflammatory molecules that favor the development of atherosclerosis. Objective: To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and high sensitivity CRP (hsCRP), in an obese children population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables. Patients and Method: A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables. Results: Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1. Conclusion: Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.
Fil: Luciardi, María Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Tucumán; Argentina
Fil: Carrizo, T. R.. Universidad Nacional de Tucumán; Argentina
Fil: Díaz, E. I.. Universidad Nacional de Tucumán; Argentina
Fil: Aleman, Mariano Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Bazán, M. C.. Provincia de Tucumán. Ministerio de Salud. Sistema Provincial de Salud. Hospital del Niño Jesús; Argentina
Fil: Abregu, A. V.. Universidad Nacional de Tucumán; Argentina
description Introduction: Obesity is a chronic disease that affects adults as well as children and is associated with insulin resistance, type 2 diabetes and cardiovascular disease. One of the reasons for the presence of low-grade inflammation in these patients could be that adipose tissue of the obese produces proinflammatory molecules that favor the development of atherosclerosis. Objective: To determine serum levels of soluble CD40 ligand (sCD40L), monocyte chemoattractant protein 1 (MCP-1), interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-α) and high sensitivity CRP (hsCRP), in an obese children population compared to a control group, also to analyze the correlation of these molecules with the anthropometric and metabolic variables. Patients and Method: A cross-sectional, observational study was carried out on 37 obese children, aged 8 to 12 years, and 20 children with normal weight. Serum levels of sCD40L, MCP-1, IL-6, TNF-α and hsCRP were determined. Data were expressed as the median and interquartil range and Spearman coefficient was used to investigate correlations between variables. Results: Compared to the control group, obese children presented significantly higher values of sCD40L, MCP-1, IL-6, TNF-α, and hsCRP than control group. Body mass index and waist circumference correlated positively with sCD40L and MCP-1. Conclusion: Elevated levels of the studied molecules studied suggest the presence of low-grade inflammation associated with obesity in this population.
publishDate 2018
dc.date.none.fl_str_mv 2018-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/268109
Luciardi, María Constanza; Carrizo, T. R.; Díaz, E. I.; Aleman, Mariano Nicolás; Bazán, M. C.; et al.; Proinflammatory state in obese children; Sociedad Chilena de Pediatría; Revista chilena de pediatría; 3; 2-2018; 346-351
0370-4106
0717-6228
CONICET Digital
CONICET
url http://hdl.handle.net/11336/268109
identifier_str_mv Luciardi, María Constanza; Carrizo, T. R.; Díaz, E. I.; Aleman, Mariano Nicolás; Bazán, M. C.; et al.; Proinflammatory state in obese children; Sociedad Chilena de Pediatría; Revista chilena de pediatría; 3; 2-2018; 346-351
0370-4106
0717-6228
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062018005000501&lng=en&nrm=iso&tlng=en
info:eu-repo/semantics/altIdentifier/doi/10.4067/S0370-41062018005000501
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Sociedad Chilena de Pediatría
publisher.none.fl_str_mv Sociedad Chilena de Pediatría
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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