Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico

Autores
Bruna, Flavia Alejandra; Fernández, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; Sepúlveda, Betsabet; Larrazabal Fuentes, María; Paredes, Adrián; Neira, Iván; Ferrando, Matías; Osorio, José Manuel; Yáñez, Osvaldo; Bravo, Jessica
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.
Fil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Diego Portales; Chile
Fil: Fernández, Katia. Universidad Diego Portales; Chile
Fil: Urrejola, Felipe. Universidad Diego Portales; Chile
Fil: Touma, Jorge. Universidad Diego Portales; Chile
Fil: Navarro, Myriam. Universidad Diego Portales; Chile
Fil: Sepúlveda, Betsabet. Universidad de Chile; Chile
Fil: Larrazabal Fuentes, María. Universidad de Antofagasta (uantof);
Fil: Paredes, Adrián. Universidad de Antofagasta (uantof);
Fil: Neira, Iván. Universidad de Antofagasta (uantof);
Fil: Ferrando, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Osorio, José Manuel. Universidad Andrés Bello; Chile. Universidad Diego Portales; Chile
Fil: Yáñez, Osvaldo. Universidad de Las Américas.; Ecuador. Center of New Drugs for Hypertension; Chile
Fil: Bravo, Jessica. Universidad Diego Portales; Chile
Materia
ANTIMICROBIAL ACTIVITY
ANTIOXIDANT
ANTIPROLIFERATIVE
CHEMICAL COMPOSITION
ESSENTIAL OIL
LAURELIOPSIS PHILIPPIANA
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/203661
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/203661
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silicoBruna, Flavia AlejandraFernández, KatiaUrrejola, FelipeTouma, JorgeNavarro, MyriamSepúlveda, BetsabetLarrazabal Fuentes, MaríaParedes, AdriánNeira, IvánFerrando, MatíasOsorio, José ManuelYáñez, OsvaldoBravo, JessicaANTIMICROBIAL ACTIVITYANTIOXIDANTANTIPROLIFERATIVECHEMICAL COMPOSITIONESSENTIAL OILLAURELIOPSIS PHILIPPIANAhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Chilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.Fil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Diego Portales; ChileFil: Fernández, Katia. Universidad Diego Portales; ChileFil: Urrejola, Felipe. Universidad Diego Portales; ChileFil: Touma, Jorge. Universidad Diego Portales; ChileFil: Navarro, Myriam. Universidad Diego Portales; ChileFil: Sepúlveda, Betsabet. Universidad de Chile; ChileFil: Larrazabal Fuentes, María. Universidad de Antofagasta (uantof);Fil: Paredes, Adrián. Universidad de Antofagasta (uantof);Fil: Neira, Iván. Universidad de Antofagasta (uantof);Fil: Ferrando, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Osorio, José Manuel. Universidad Andrés Bello; Chile. Universidad Diego Portales; ChileFil: Yáñez, Osvaldo. Universidad de Las Américas.; Ecuador. Center of New Drugs for Hypertension; ChileFil: Bravo, Jessica. Universidad Diego Portales; ChileElsevier2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/203661Bruna, Flavia Alejandra; Fernández, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; et al.; Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico; Elsevier; Arabian Journal of Chemistry; 15; 12; 12-2022; 1-281878-5352CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1878535222005871info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arabjc.2022.104271info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:12Zoai:ri.conicet.gov.ar:11336/203661instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:12.699CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
title Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
spellingShingle Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
Bruna, Flavia Alejandra
ANTIMICROBIAL ACTIVITY
ANTIOXIDANT
ANTIPROLIFERATIVE
CHEMICAL COMPOSITION
ESSENTIAL OIL
LAURELIOPSIS PHILIPPIANA
title_short Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
title_full Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
title_fullStr Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
title_full_unstemmed Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
title_sort Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico
dc.creator.none.fl_str_mv Bruna, Flavia Alejandra
Fernández, Katia
Urrejola, Felipe
Touma, Jorge
Navarro, Myriam
Sepúlveda, Betsabet
Larrazabal Fuentes, María
Paredes, Adrián
Neira, Iván
Ferrando, Matías
Osorio, José Manuel
Yáñez, Osvaldo
Bravo, Jessica
author Bruna, Flavia Alejandra
author_facet Bruna, Flavia Alejandra
Fernández, Katia
Urrejola, Felipe
Touma, Jorge
Navarro, Myriam
Sepúlveda, Betsabet
Larrazabal Fuentes, María
Paredes, Adrián
Neira, Iván
Ferrando, Matías
Osorio, José Manuel
Yáñez, Osvaldo
Bravo, Jessica
author_role author
author2 Fernández, Katia
Urrejola, Felipe
Touma, Jorge
Navarro, Myriam
Sepúlveda, Betsabet
Larrazabal Fuentes, María
Paredes, Adrián
Neira, Iván
Ferrando, Matías
Osorio, José Manuel
Yáñez, Osvaldo
Bravo, Jessica
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIMICROBIAL ACTIVITY
ANTIOXIDANT
ANTIPROLIFERATIVE
CHEMICAL COMPOSITION
ESSENTIAL OIL
LAURELIOPSIS PHILIPPIANA
topic ANTIMICROBIAL ACTIVITY
ANTIOXIDANT
ANTIPROLIFERATIVE
CHEMICAL COMPOSITION
ESSENTIAL OIL
LAURELIOPSIS PHILIPPIANA
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.
Fil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Diego Portales; Chile
Fil: Fernández, Katia. Universidad Diego Portales; Chile
Fil: Urrejola, Felipe. Universidad Diego Portales; Chile
Fil: Touma, Jorge. Universidad Diego Portales; Chile
Fil: Navarro, Myriam. Universidad Diego Portales; Chile
Fil: Sepúlveda, Betsabet. Universidad de Chile; Chile
Fil: Larrazabal Fuentes, María. Universidad de Antofagasta (uantof);
Fil: Paredes, Adrián. Universidad de Antofagasta (uantof);
Fil: Neira, Iván. Universidad de Antofagasta (uantof);
Fil: Ferrando, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Osorio, José Manuel. Universidad Andrés Bello; Chile. Universidad Diego Portales; Chile
Fil: Yáñez, Osvaldo. Universidad de Las Américas.; Ecuador. Center of New Drugs for Hypertension; Chile
Fil: Bravo, Jessica. Universidad Diego Portales; Chile
description Chilean Laureliopsis philippiana has been used in traditional medicine by the Mapuche and their ancestors. To evaluate its pharmacological activity, Laureliopsis philippiana leaf essential oil extract (LP_EO) was chemically and biologically characterized in the present study. In vitro antioxidant potential was analyzed, and antitumor activity was evaluated in non-tumor and tumor cell culture lines. Caenorhabditis elegans was used as a model for evaluating toxicity, and the chemical composition of the essential oil was analyzed using gas chromatography–mass spectrometry. The oil contains six major monoterpenes: eucalyptol (27.7 %), linalool (27.6 %), isozaphrol (19.5 %), isohomogenol (12.6 %), α-terpineol (7.7 %), and eudesmol (4.8 %). Based on quantum mechanical calculations, isosafrole and isohomogenol conferred in vitro antioxidant and antimicrobial activity to LP_EO. In addition, LP_EO showed antimicrobial activity against clinical Helicobacter pylori isolates (MIC 64 and MBC > 128 μg·mL−1), Staphylococcus aureus (MIC 32 and MBC > 64 μg·mL−1), Escherichia coli (MIC 8 and MBC 16 μg·mL−1) and Candida albicans (MIC 64 and > 128 μg·mL−1). LP_EO could selectively inhibit the proliferation of epithelial tumor cell lines but showed low toxicity against Caenorhabditis elegans (0.39 to 1.56 μg·mL−1). Therefore, LP_EO may be used as a source of bioactive compounds in novel pharmacological treatments for veterinary and human application, cosmetics, or sanitation.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/203661
Bruna, Flavia Alejandra; Fernández, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; et al.; Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico; Elsevier; Arabian Journal of Chemistry; 15; 12; 12-2022; 1-28
1878-5352
CONICET Digital
CONICET
url http://hdl.handle.net/11336/203661
identifier_str_mv Bruna, Flavia Alejandra; Fernández, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; et al.; Chemical composition, antioxidant, antimicrobial and antiproliferative activity of Laureliopsis philippiana essential oil of Chile, study in vitro and in silico; Elsevier; Arabian Journal of Chemistry; 15; 12; 12-2022; 1-28
1878-5352
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1878535222005871
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.arabjc.2022.104271
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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