Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs

Autores
Castro, Jose Alberto; Castro, Gerardo Daniel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epidemiological studies conducted in different countries showed that alcohol abuse in the youth and the adolescent is a problem of growing interest and relevance. Consequently, it can be envisaged that the number of adult drinkers is going to increase in the years to come. The detrimental effect of alcohol consumption on the health of young people is particularly serious when one considers that, with respect to reproductive health, this is the age range more relevant in both sexes. In women, reproductive health is not a minor issue, considering the alarming increase in drinking at an age directly related to the fertility window. It is important to note that due to differences in the metabolism of ethanol, women, compared with men, is facing an increased risk of negative consequences associated with the consumption of large amounts of alcohol. Harmful consequences of alcohol abuse have been reported in women such as a significant risk of infertility and an increased risk for endometriosis. Other studies concluded that the probability of a successful pregnancy decreased with the increase in the consumption of alcohol. For men, a large number of epidemiological studies evidenced that excessive alcohol consumption is associated with impaired testosterone production and testicular atrophy. Reproductive disorders caused by drinking should certainly involve alterations in critical hormonal factors controlling reproductive functions but also related to the direct toxic action of ethanol and its metabolites in the organs that constitute the reproductive systems of both sexes.
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina
Fil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina
Materia
Ethanol
Acetaldehyde
Reproductive Toxicity
Alcohol
Uterus
Testes
Prostate
Ovary
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29875
Acceder
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spelling Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organsCastro, Jose AlbertoCastro, Gerardo DanielEthanolAcetaldehydeReproductive ToxicityAlcoholUterusTestesProstateOvaryOxidative Stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Epidemiological studies conducted in different countries showed that alcohol abuse in the youth and the adolescent is a problem of growing interest and relevance. Consequently, it can be envisaged that the number of adult drinkers is going to increase in the years to come. The detrimental effect of alcohol consumption on the health of young people is particularly serious when one considers that, with respect to reproductive health, this is the age range more relevant in both sexes. In women, reproductive health is not a minor issue, considering the alarming increase in drinking at an age directly related to the fertility window. It is important to note that due to differences in the metabolism of ethanol, women, compared with men, is facing an increased risk of negative consequences associated with the consumption of large amounts of alcohol. Harmful consequences of alcohol abuse have been reported in women such as a significant risk of infertility and an increased risk for endometriosis. Other studies concluded that the probability of a successful pregnancy decreased with the increase in the consumption of alcohol. For men, a large number of epidemiological studies evidenced that excessive alcohol consumption is associated with impaired testosterone production and testicular atrophy. Reproductive disorders caused by drinking should certainly involve alterations in critical hormonal factors controlling reproductive functions but also related to the direct toxic action of ethanol and its metabolites in the organs that constitute the reproductive systems of both sexes.Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; ArgentinaFil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; ArgentinaResearch Trends2014-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29875Castro, Jose Alberto; Castro, Gerardo Daniel; Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs; Research Trends; Current Topics in Toxicology; 10; 12-2014; 1-160972-8228CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=10&tid=50&aid=5552&pub=2014&type=3info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:22:43Zoai:ri.conicet.gov.ar:11336/29875instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:22:43.941CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
title Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
spellingShingle Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
Castro, Jose Alberto
Ethanol
Acetaldehyde
Reproductive Toxicity
Alcohol
Uterus
Testes
Prostate
Ovary
Oxidative Stress
title_short Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
title_full Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
title_fullStr Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
title_full_unstemmed Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
title_sort Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs
dc.creator.none.fl_str_mv Castro, Jose Alberto
Castro, Gerardo Daniel
author Castro, Jose Alberto
author_facet Castro, Jose Alberto
Castro, Gerardo Daniel
author_role author
author2 Castro, Gerardo Daniel
author2_role author
dc.subject.none.fl_str_mv Ethanol
Acetaldehyde
Reproductive Toxicity
Alcohol
Uterus
Testes
Prostate
Ovary
Oxidative Stress
topic Ethanol
Acetaldehyde
Reproductive Toxicity
Alcohol
Uterus
Testes
Prostate
Ovary
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Epidemiological studies conducted in different countries showed that alcohol abuse in the youth and the adolescent is a problem of growing interest and relevance. Consequently, it can be envisaged that the number of adult drinkers is going to increase in the years to come. The detrimental effect of alcohol consumption on the health of young people is particularly serious when one considers that, with respect to reproductive health, this is the age range more relevant in both sexes. In women, reproductive health is not a minor issue, considering the alarming increase in drinking at an age directly related to the fertility window. It is important to note that due to differences in the metabolism of ethanol, women, compared with men, is facing an increased risk of negative consequences associated with the consumption of large amounts of alcohol. Harmful consequences of alcohol abuse have been reported in women such as a significant risk of infertility and an increased risk for endometriosis. Other studies concluded that the probability of a successful pregnancy decreased with the increase in the consumption of alcohol. For men, a large number of epidemiological studies evidenced that excessive alcohol consumption is associated with impaired testosterone production and testicular atrophy. Reproductive disorders caused by drinking should certainly involve alterations in critical hormonal factors controlling reproductive functions but also related to the direct toxic action of ethanol and its metabolites in the organs that constitute the reproductive systems of both sexes.
Fil: Castro, Jose Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina
Fil: Castro, Gerardo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Unidad de Investigación y Desarrollo Estratégico para la Defensa. Ministerio de Defensa. Unidad de Investigación y Desarrollo Estratégico para la Defensa; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. GP. CITEFA - Centro de Investigaciones Toxicológicas (I); Argentina. Ministerio de Defensa. Instituto de Investigaciones Científicas y Técnicas para la Defensa; Argentina
description Epidemiological studies conducted in different countries showed that alcohol abuse in the youth and the adolescent is a problem of growing interest and relevance. Consequently, it can be envisaged that the number of adult drinkers is going to increase in the years to come. The detrimental effect of alcohol consumption on the health of young people is particularly serious when one considers that, with respect to reproductive health, this is the age range more relevant in both sexes. In women, reproductive health is not a minor issue, considering the alarming increase in drinking at an age directly related to the fertility window. It is important to note that due to differences in the metabolism of ethanol, women, compared with men, is facing an increased risk of negative consequences associated with the consumption of large amounts of alcohol. Harmful consequences of alcohol abuse have been reported in women such as a significant risk of infertility and an increased risk for endometriosis. Other studies concluded that the probability of a successful pregnancy decreased with the increase in the consumption of alcohol. For men, a large number of epidemiological studies evidenced that excessive alcohol consumption is associated with impaired testosterone production and testicular atrophy. Reproductive disorders caused by drinking should certainly involve alterations in critical hormonal factors controlling reproductive functions but also related to the direct toxic action of ethanol and its metabolites in the organs that constitute the reproductive systems of both sexes.
publishDate 2014
dc.date.none.fl_str_mv 2014-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29875
Castro, Jose Alberto; Castro, Gerardo Daniel; Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs; Research Trends; Current Topics in Toxicology; 10; 12-2014; 1-16
0972-8228
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29875
identifier_str_mv Castro, Jose Alberto; Castro, Gerardo Daniel; Alcohol consumption and reproductive toxicity: The role of in situ metabolism of ethanol in target organs; Research Trends; Current Topics in Toxicology; 10; 12-2014; 1-16
0972-8228
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.researchtrends.net/tia/abstract.asp?in=0&vn=10&tid=50&aid=5552&pub=2014&type=3
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Research Trends
publisher.none.fl_str_mv Research Trends
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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