Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations

Autores
Grecco, Sofía; Condon, Emma; Bucafusco, Danilo; Bratanich, Ana Cristina; Panzera, Yanina; Pérez, Ruben
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Canine parvovirus (CPV) is a significant pathogen in domestic dogs worldwide, causing a severe and often fatal disease. CPV comprises three antigenic variants (2a, 2b, and 2c) distributed unevenly among several phylogenetic groups. The present study compared genetic variability and evolutionary patterns in South American CPV populations. We collected samples from puppies suspected of CPV infection in the neighboring Argentina and Uruguay. Antigenic variants were preliminarily characterized using PCR-RFLP and partial vp2 sequencing. Samples collected in Argentina during 2008-2018 were mainly of the 2c variant. In the Uruguayan strains (2012-2019), the 2a variant wholly replaced the 2c from 2014. Full-length coding genome and vp2 sequences were compared with global strains. The 2c and 2a strains fell by phylogenetic analysis into two phylogroups (Europe I and Asia I). The 2c strains from Argentina and Uruguay clustered in the Europe I group, with strains from America, Europe, Asia, and Oceania. Europe I is widely distributed in South America in the dog population and is also being detected in the wildlife population. The 2a strains from Uruguay formed the distinct Asia I group with strains from Asia, Africa, America, and Oceania. This Asia I group is increasing its distribution in South America and worldwide. Our research reveals high genetic variability in adjacent synchronic samples and different evolutionary patterns in South American CPV. We also highlight the importance of ancestral migrations and local diversification in the evolution of global CPV strains.
Fil: Grecco, Sofía. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Condon, Emma. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Bratanich, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias; Uruguay
Materia
Canine parvovirus
Evolution
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/258506
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Comparative genomics of canine parvovirus in South America: Diversification patterns in local populationsGrecco, SofíaCondon, EmmaBucafusco, DaniloBratanich, Ana CristinaPanzera, YaninaPérez, RubenCanine parvovirusEvolutionhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Canine parvovirus (CPV) is a significant pathogen in domestic dogs worldwide, causing a severe and often fatal disease. CPV comprises three antigenic variants (2a, 2b, and 2c) distributed unevenly among several phylogenetic groups. The present study compared genetic variability and evolutionary patterns in South American CPV populations. We collected samples from puppies suspected of CPV infection in the neighboring Argentina and Uruguay. Antigenic variants were preliminarily characterized using PCR-RFLP and partial vp2 sequencing. Samples collected in Argentina during 2008-2018 were mainly of the 2c variant. In the Uruguayan strains (2012-2019), the 2a variant wholly replaced the 2c from 2014. Full-length coding genome and vp2 sequences were compared with global strains. The 2c and 2a strains fell by phylogenetic analysis into two phylogroups (Europe I and Asia I). The 2c strains from Argentina and Uruguay clustered in the Europe I group, with strains from America, Europe, Asia, and Oceania. Europe I is widely distributed in South America in the dog population and is also being detected in the wildlife population. The 2a strains from Uruguay formed the distinct Asia I group with strains from Asia, Africa, America, and Oceania. This Asia I group is increasing its distribution in South America and worldwide. Our research reveals high genetic variability in adjacent synchronic samples and different evolutionary patterns in South American CPV. We also highlight the importance of ancestral migrations and local diversification in the evolution of global CPV strains.Fil: Grecco, Sofía. Universidad de la República. Facultad de Ciencias; UruguayFil: Condon, Emma. Universidad de la República. Facultad de Ciencias; UruguayFil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; ArgentinaFil: Bratanich, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; ArgentinaFil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias; UruguayFil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias; UruguayElsevier Science2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/258506Grecco, Sofía; Condon, Emma; Bucafusco, Danilo; Bratanich, Ana Cristina; Panzera, Yanina; et al.; Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations; Elsevier Science; Infection, Genetics and Evolution; 123; 9-2024; 1-91567-1348CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1567134824000844info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2024.105633info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:24:15Zoai:ri.conicet.gov.ar:11336/258506instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:24:15.949CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
title Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
spellingShingle Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
Grecco, Sofía
Canine parvovirus
Evolution
title_short Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
title_full Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
title_fullStr Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
title_full_unstemmed Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
title_sort Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations
dc.creator.none.fl_str_mv Grecco, Sofía
Condon, Emma
Bucafusco, Danilo
Bratanich, Ana Cristina
Panzera, Yanina
Pérez, Ruben
author Grecco, Sofía
author_facet Grecco, Sofía
Condon, Emma
Bucafusco, Danilo
Bratanich, Ana Cristina
Panzera, Yanina
Pérez, Ruben
author_role author
author2 Condon, Emma
Bucafusco, Danilo
Bratanich, Ana Cristina
Panzera, Yanina
Pérez, Ruben
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Canine parvovirus
Evolution
topic Canine parvovirus
Evolution
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Canine parvovirus (CPV) is a significant pathogen in domestic dogs worldwide, causing a severe and often fatal disease. CPV comprises three antigenic variants (2a, 2b, and 2c) distributed unevenly among several phylogenetic groups. The present study compared genetic variability and evolutionary patterns in South American CPV populations. We collected samples from puppies suspected of CPV infection in the neighboring Argentina and Uruguay. Antigenic variants were preliminarily characterized using PCR-RFLP and partial vp2 sequencing. Samples collected in Argentina during 2008-2018 were mainly of the 2c variant. In the Uruguayan strains (2012-2019), the 2a variant wholly replaced the 2c from 2014. Full-length coding genome and vp2 sequences were compared with global strains. The 2c and 2a strains fell by phylogenetic analysis into two phylogroups (Europe I and Asia I). The 2c strains from Argentina and Uruguay clustered in the Europe I group, with strains from America, Europe, Asia, and Oceania. Europe I is widely distributed in South America in the dog population and is also being detected in the wildlife population. The 2a strains from Uruguay formed the distinct Asia I group with strains from Asia, Africa, America, and Oceania. This Asia I group is increasing its distribution in South America and worldwide. Our research reveals high genetic variability in adjacent synchronic samples and different evolutionary patterns in South American CPV. We also highlight the importance of ancestral migrations and local diversification in the evolution of global CPV strains.
Fil: Grecco, Sofía. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Condon, Emma. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Bucafusco, Danilo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Bratanich, Ana Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Unidad Ejecutora de Investigaciones en Producción Animal. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Unidad Ejecutora de Investigaciones en Producción Animal; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento Virologia; Argentina
Fil: Panzera, Yanina. Universidad de la República. Facultad de Ciencias; Uruguay
Fil: Pérez, Ruben. Universidad de la República. Facultad de Ciencias; Uruguay
description Canine parvovirus (CPV) is a significant pathogen in domestic dogs worldwide, causing a severe and often fatal disease. CPV comprises three antigenic variants (2a, 2b, and 2c) distributed unevenly among several phylogenetic groups. The present study compared genetic variability and evolutionary patterns in South American CPV populations. We collected samples from puppies suspected of CPV infection in the neighboring Argentina and Uruguay. Antigenic variants were preliminarily characterized using PCR-RFLP and partial vp2 sequencing. Samples collected in Argentina during 2008-2018 were mainly of the 2c variant. In the Uruguayan strains (2012-2019), the 2a variant wholly replaced the 2c from 2014. Full-length coding genome and vp2 sequences were compared with global strains. The 2c and 2a strains fell by phylogenetic analysis into two phylogroups (Europe I and Asia I). The 2c strains from Argentina and Uruguay clustered in the Europe I group, with strains from America, Europe, Asia, and Oceania. Europe I is widely distributed in South America in the dog population and is also being detected in the wildlife population. The 2a strains from Uruguay formed the distinct Asia I group with strains from Asia, Africa, America, and Oceania. This Asia I group is increasing its distribution in South America and worldwide. Our research reveals high genetic variability in adjacent synchronic samples and different evolutionary patterns in South American CPV. We also highlight the importance of ancestral migrations and local diversification in the evolution of global CPV strains.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/258506
Grecco, Sofía; Condon, Emma; Bucafusco, Danilo; Bratanich, Ana Cristina; Panzera, Yanina; et al.; Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations; Elsevier Science; Infection, Genetics and Evolution; 123; 9-2024; 1-9
1567-1348
CONICET Digital
CONICET
url http://hdl.handle.net/11336/258506
identifier_str_mv Grecco, Sofía; Condon, Emma; Bucafusco, Danilo; Bratanich, Ana Cristina; Panzera, Yanina; et al.; Comparative genomics of canine parvovirus in South America: Diversification patterns in local populations; Elsevier Science; Infection, Genetics and Evolution; 123; 9-2024; 1-9
1567-1348
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1567134824000844
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.meegid.2024.105633
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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