Anatomy, function and regulation of neuropeptide EI (NEI)

Autores
Bittencourt, Jackson; Cobe, Maria Esther
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.
Fil: Bittencourt, Jackson. Universidade de Sao Paulo; Brasil
Fil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; Argentina
Materia
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
ANATOMY
PHYSIOLOGY
BEHAVIOUR
HORMONES
REGULATION: CNS
IMMUNOREACTIVITY
RATS
NEUROTRANSMITERS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/242112
Acceder
id CONICETDig_a9b2460ed4e4ca95c3caa185902f243f
oai_identifier_str oai:ri.conicet.gov.ar:11336/242112
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Anatomy, function and regulation of neuropeptide EI (NEI)Bittencourt, JacksonCobe, Maria EstherNEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)ANATOMYPHYSIOLOGYBEHAVIOURHORMONESREGULATION: CNSIMMUNOREACTIVITYRATSNEUROTRANSMITERShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.Fil: Bittencourt, Jackson. Universidade de Sao Paulo; BrasilFil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; ArgentinaElsevier Science Inc.2008-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242112Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-14500196-9781CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978108001332info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2008.03.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:05:25Zoai:ri.conicet.gov.ar:11336/242112instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:05:25.975CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Anatomy, function and regulation of neuropeptide EI (NEI)
title Anatomy, function and regulation of neuropeptide EI (NEI)
spellingShingle Anatomy, function and regulation of neuropeptide EI (NEI)
Bittencourt, Jackson
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
ANATOMY
PHYSIOLOGY
BEHAVIOUR
HORMONES
REGULATION: CNS
IMMUNOREACTIVITY
RATS
NEUROTRANSMITERS
title_short Anatomy, function and regulation of neuropeptide EI (NEI)
title_full Anatomy, function and regulation of neuropeptide EI (NEI)
title_fullStr Anatomy, function and regulation of neuropeptide EI (NEI)
title_full_unstemmed Anatomy, function and regulation of neuropeptide EI (NEI)
title_sort Anatomy, function and regulation of neuropeptide EI (NEI)
dc.creator.none.fl_str_mv Bittencourt, Jackson
Cobe, Maria Esther
author Bittencourt, Jackson
author_facet Bittencourt, Jackson
Cobe, Maria Esther
author_role author
author2 Cobe, Maria Esther
author2_role author
dc.subject.none.fl_str_mv NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
ANATOMY
PHYSIOLOGY
BEHAVIOUR
HORMONES
REGULATION: CNS
IMMUNOREACTIVITY
RATS
NEUROTRANSMITERS
topic NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
ANATOMY
PHYSIOLOGY
BEHAVIOUR
HORMONES
REGULATION: CNS
IMMUNOREACTIVITY
RATS
NEUROTRANSMITERS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.
Fil: Bittencourt, Jackson. Universidade de Sao Paulo; Brasil
Fil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; Argentina
description This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.
publishDate 2008
dc.date.none.fl_str_mv 2008-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/242112
Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-1450
0196-9781
CONICET Digital
CONICET
url http://hdl.handle.net/11336/242112
identifier_str_mv Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-1450
0196-9781
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978108001332
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2008.03.012
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781333299265536
score 12.982451

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