Anatomy, function and regulation of neuropeptide EI (NEI)
- Autores
- Bittencourt, Jackson; Cobe, Maria Esther
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.
Fil: Bittencourt, Jackson. Universidade de Sao Paulo; Brasil
Fil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; Argentina - Materia
-
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)
ANATOMY
PHYSIOLOGY
BEHAVIOUR
HORMONES
REGULATION: CNS
IMMUNOREACTIVITY
RATS
NEUROTRANSMITERS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/242112
Ver los metadatos del registro completo
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Anatomy, function and regulation of neuropeptide EI (NEI)Bittencourt, JacksonCobe, Maria EstherNEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI)ANATOMYPHYSIOLOGYBEHAVIOURHORMONESREGULATION: CNSIMMUNOREACTIVITYRATSNEUROTRANSMITERShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons.Fil: Bittencourt, Jackson. Universidade de Sao Paulo; BrasilFil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; ArgentinaElsevier Science Inc.2008-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/242112Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-14500196-9781CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978108001332info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2008.03.012info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:17Zoai:ri.conicet.gov.ar:11336/242112instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:17.987CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Anatomy, function and regulation of neuropeptide EI (NEI) |
title |
Anatomy, function and regulation of neuropeptide EI (NEI) |
spellingShingle |
Anatomy, function and regulation of neuropeptide EI (NEI) Bittencourt, Jackson NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI) ANATOMY PHYSIOLOGY BEHAVIOUR HORMONES REGULATION: CNS IMMUNOREACTIVITY RATS NEUROTRANSMITERS |
title_short |
Anatomy, function and regulation of neuropeptide EI (NEI) |
title_full |
Anatomy, function and regulation of neuropeptide EI (NEI) |
title_fullStr |
Anatomy, function and regulation of neuropeptide EI (NEI) |
title_full_unstemmed |
Anatomy, function and regulation of neuropeptide EI (NEI) |
title_sort |
Anatomy, function and regulation of neuropeptide EI (NEI) |
dc.creator.none.fl_str_mv |
Bittencourt, Jackson Cobe, Maria Esther |
author |
Bittencourt, Jackson |
author_facet |
Bittencourt, Jackson Cobe, Maria Esther |
author_role |
author |
author2 |
Cobe, Maria Esther |
author2_role |
author |
dc.subject.none.fl_str_mv |
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI) ANATOMY PHYSIOLOGY BEHAVIOUR HORMONES REGULATION: CNS IMMUNOREACTIVITY RATS NEUROTRANSMITERS |
topic |
NEUROPEPTIDE-GLUTAMIC ACID-ISOLEUCINE (NEI) ANATOMY PHYSIOLOGY BEHAVIOUR HORMONES REGULATION: CNS IMMUNOREACTIVITY RATS NEUROTRANSMITERS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons. Fil: Bittencourt, Jackson. Universidade de Sao Paulo; Brasil Fil: Cobe, Maria Esther. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina. Universidad Nacional de Córdoba. Facultad de Medicina. Departamento de Medicina. Cátedra de Bacteriología y Virología Médicas; Argentina |
description |
This review is focused on the anatomy, role and behavior of neuropeptide-glutamic acid- isoleucine (NEI), providing a general report on the neuropeptide. In addition to hormone release, this peptide also takes part in the regulation of grooming behavior and locomotor activity. NEI is produced by cleavage of prepro-MCH that probably takes place at the Lys129-Arg130 and Arg145-Arg146 sites (the glycine residue on the C-terminus of NEI strongly suggests that this peptide is amidated). This same prohormone is also the precursor of MCH, widely studied in relation to food and water intake, and NGE, of which little is known. NEI and MCH are extensively colocalized throughout the central nervous system (CNS), and NEI is also present in peripheral tissues. The latter is also effective in stimulating luteinizing hormone (LH) release and, to a lesser extent, FSH from primary pituitary cell cultures. In addition to releasing LH from the medial eminence, NEI also acts directly on gonadotropes. Lastly, this neuropeptide also acts at the CNS level on gonadotropin-releasing hormone (GnRH) neurons. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/242112 Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-1450 0196-9781 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/242112 |
identifier_str_mv |
Bittencourt, Jackson; Cobe, Maria Esther; Anatomy, function and regulation of neuropeptide EI (NEI); Elsevier Science Inc.; Peptides; 29; 8; 8-2008; 1441-1450 0196-9781 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978108001332 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2008.03.012 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science Inc. |
publisher.none.fl_str_mv |
Elsevier Science Inc. |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613174393831424 |
score |
13.070432 |