Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats

Autores
Ayala, Carolina; Valdez, Susana Ruth; Navarra Morero, María Luján; Soaje, Marta; Carreño, Norma Beatriz; Sanchez, Monica Silvina; Bittencourt, Jakson Cioni; Jahn, Graciela Alma; Celis, María Ester
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and l-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of l-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis.
Fil: Ayala, Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Valdez, Susana Ruth. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Navarra Morero, María Luján. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Soaje, Marta. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Carreño, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Bittencourt, Jakson Cioni. Universidade de Sao Paulo; Brasil
Fil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Materia
ADULT MALE RAT
BRAIN AREAS
HYPERTHYROIDISM
HYPOTHALAMIC-PITUITARY-THYROID (HPT) AXIS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC ACID-ISOLEUCINE-AMIDE (NEI)
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/193940
Acceder
id CONICETDig_cba472b5276f7cb792c12524d3045f58
oai_identifier_str oai:ri.conicet.gov.ar:11336/193940
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male ratsAyala, CarolinaValdez, Susana RuthNavarra Morero, María LujánSoaje, MartaCarreño, Norma BeatrizSanchez, Monica SilvinaBittencourt, Jakson CioniJahn, Graciela AlmaCelis, María EsterADULT MALE RATBRAIN AREASHYPERTHYROIDISMHYPOTHALAMIC-PITUITARY-THYROID (HPT) AXISHYPOTHYROIDISMNEUROPEPTIDE GLUTAMIC ACID-ISOLEUCINE-AMIDE (NEI)https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and l-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of l-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis.Fil: Ayala, Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; ArgentinaFil: Valdez, Susana Ruth. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Navarra Morero, María Luján. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaFil: Soaje, Marta. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Carreño, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Bittencourt, Jakson Cioni. Universidade de Sao Paulo; BrasilFil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Medicina; ArgentinaElsevier Science Inc.2011-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/193940Ayala, Carolina; Valdez, Susana Ruth; Navarra Morero, María Luján; Soaje, Marta; Carreño, Norma Beatriz; et al.; Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats; Elsevier Science Inc.; Peptides; 32; 6; 6-2011; 1249-12540196-9781CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978111001252info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2011.03.020info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:26:28Zoai:ri.conicet.gov.ar:11336/193940instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:26:29.17CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
title Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
spellingShingle Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
Ayala, Carolina
ADULT MALE RAT
BRAIN AREAS
HYPERTHYROIDISM
HYPOTHALAMIC-PITUITARY-THYROID (HPT) AXIS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC ACID-ISOLEUCINE-AMIDE (NEI)
title_short Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
title_full Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
title_fullStr Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
title_full_unstemmed Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
title_sort Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats
dc.creator.none.fl_str_mv Ayala, Carolina
Valdez, Susana Ruth
Navarra Morero, María Luján
Soaje, Marta
Carreño, Norma Beatriz
Sanchez, Monica Silvina
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, María Ester
author Ayala, Carolina
author_facet Ayala, Carolina
Valdez, Susana Ruth
Navarra Morero, María Luján
Soaje, Marta
Carreño, Norma Beatriz
Sanchez, Monica Silvina
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, María Ester
author_role author
author2 Valdez, Susana Ruth
Navarra Morero, María Luján
Soaje, Marta
Carreño, Norma Beatriz
Sanchez, Monica Silvina
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, María Ester
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADULT MALE RAT
BRAIN AREAS
HYPERTHYROIDISM
HYPOTHALAMIC-PITUITARY-THYROID (HPT) AXIS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC ACID-ISOLEUCINE-AMIDE (NEI)
topic ADULT MALE RAT
BRAIN AREAS
HYPERTHYROIDISM
HYPOTHALAMIC-PITUITARY-THYROID (HPT) AXIS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC ACID-ISOLEUCINE-AMIDE (NEI)
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and l-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of l-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis.
Fil: Ayala, Carolina. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina
Fil: Valdez, Susana Ruth. Universidad Nacional de Cuyo; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Navarra Morero, María Luján. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
Fil: Soaje, Marta. Universidad de Mendoza; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Carreño, Norma Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Bittencourt, Jakson Cioni. Universidade de Sao Paulo; Brasil
Fil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Celis, María Ester. Universidad Nacional de Córdoba. Facultad de Medicina; Argentina
description To date, there has been only one in vitro study of the relationship between neuropeptide EI (NEI) and the hypothalamic-pituitary-thyroid (HPT) axis. To investigate the possible relationship between NEI and the HPT axis, we developed a rat model of hypothyroidism and hyperthyroidism that allows us to determine whether NEI content is altered in selected brain areas after treatment, as well as whether such alterations are related to the time of day. Hypothyroidism and hyperthyroidism, induced in male rats, with 6-propyl-1-thiouracil and l-thyroxine, respectively, were confirmed by determination of triiodothyronine, total thyroxine, and thyrotropin levels. All groups were studied at the morning and the afternoon. In rats with hypothyroidism, NEI concentration, evaluated on postinduction days 7 and 24, was unchanged or slightly elevated on day 7 but was decreased on day 24. In rats with hyperthyroidism, NEI content, which was evaluated after 4 days of l-thyroxine administration, was slightly elevated, principally in the preoptic area in the morning and in the median eminence-arcuate nucleus and pineal gland in the afternoon, the morning and afternoon NEI contents being similar in the controls. These results provide the bases to pursue the study of the interaction between NEI and the HPT axis.
publishDate 2011
dc.date.none.fl_str_mv 2011-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/193940
Ayala, Carolina; Valdez, Susana Ruth; Navarra Morero, María Luján; Soaje, Marta; Carreño, Norma Beatriz; et al.; Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats; Elsevier Science Inc.; Peptides; 32; 6; 6-2011; 1249-1254
0196-9781
CONICET Digital
CONICET
url http://hdl.handle.net/11336/193940
identifier_str_mv Ayala, Carolina; Valdez, Susana Ruth; Navarra Morero, María Luján; Soaje, Marta; Carreño, Norma Beatriz; et al.; Hypo- and hyperthyroidism affect NEI concentration in discrete brain areas of adult male rats; Elsevier Science Inc.; Peptides; 32; 6; 6-2011; 1249-1254
0196-9781
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0196978111001252
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2011.03.020
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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