Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle

Autores
Ayala, Carolina; Pennacchio, Gisela Erika; Soaje, Marta; Carreño, Norma Beatriz; Bittencourt, Jakson Cioni; Jahn, Graciela Alma; Celis, Maria Esther; Valdez, Susana Ruth
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract: We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine amide (NEI) concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone (LH), estradiol and progesterone concentrations were measured in control, hypothyroid (hypoT, treated with PTU during 7-9 days) and hyperthyroid (hyperT, L-T4 during 4-7 days) animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon (P-PM), although hypoT rats showed lower values compared to control during proestrus morning (P-AM). Progesterone levels were higher in all groups at P-PM and in the hyperT during diestrus morning (D2). NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus (E) in the peduncular part of the lateral hypothalamus (PLH). They were also reduced by both treatments in the perifornical part of the lateral hypothalamus(PeFLH) during P-PM. Hypothyroidism led to higher NEI concentrations during P-PM in the organum vasculosum of the lamina terminalis and anteroventral periventricular nucleus (OVLT + AVPV). The present results indicate that NEI concentration is regulated in a complex manner by hypoand hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies.
Fil: Ayala, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Soaje, Marta. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; Argentina
Fil: Carreño, Norma Beatriz. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; Argentina
Fil: Bittencourt, Jakson Cioni. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil;
Fil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Celis, Maria Esther. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Medicina. Cat.de Bacteriologia y Virologia Medicas; Argentina
Fil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
ESTROUS CYCLE
HYPERTHYROIDISM
HYPOTHALAMUS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC-ACID-ISOLEUCINE-AMIDE (NEI)
REPRODUCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/1547
Acceder
id CONICETDig_8ffc5151baf413073e6c3ed014af8e33
oai_identifier_str oai:ri.conicet.gov.ar:11336/1547
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycleAyala, CarolinaPennacchio, Gisela ErikaSoaje, MartaCarreño, Norma BeatrizBittencourt, Jakson CioniJahn, Graciela AlmaCelis, Maria EstherValdez, Susana RuthESTROUS CYCLEHYPERTHYROIDISMHYPOTHALAMUSHYPOTHYROIDISMNEUROPEPTIDE GLUTAMIC-ACID-ISOLEUCINE-AMIDE (NEI)REPRODUCTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Abstract: We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine amide (NEI) concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone (LH), estradiol and progesterone concentrations were measured in control, hypothyroid (hypoT, treated with PTU during 7-9 days) and hyperthyroid (hyperT, L-T4 during 4-7 days) animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon (P-PM), although hypoT rats showed lower values compared to control during proestrus morning (P-AM). Progesterone levels were higher in all groups at P-PM and in the hyperT during diestrus morning (D2). NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus (E) in the peduncular part of the lateral hypothalamus (PLH). They were also reduced by both treatments in the perifornical part of the lateral hypothalamus(PeFLH) during P-PM. Hypothyroidism led to higher NEI concentrations during P-PM in the organum vasculosum of the lamina terminalis and anteroventral periventricular nucleus (OVLT + AVPV). The present results indicate that NEI concentration is regulated in a complex manner by hypoand hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies.Fil: Ayala, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Córdoba; ArgentinaFil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Soaje, Marta. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; ArgentinaFil: Carreño, Norma Beatriz. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; ArgentinaFil: Bittencourt, Jakson Cioni. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil;Fil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Celis, Maria Esther. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Medicina. Cat.de Bacteriologia y Virologia Medicas; ArgentinaFil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaElsevier Science Inc2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/1547Ayala, Carolina; Pennacchio, Gisela Erika; Soaje, Marta; Carreño, Norma Beatriz; Bittencourt, Jakson Cioni; et al.; Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle; Elsevier Science Inc; Peptides; 49; 9-2013; 74-800196-9781enginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2013.08.016info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:48:17Zoai:ri.conicet.gov.ar:11336/1547instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:48:17.821CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
title Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
spellingShingle Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
Ayala, Carolina
ESTROUS CYCLE
HYPERTHYROIDISM
HYPOTHALAMUS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC-ACID-ISOLEUCINE-AMIDE (NEI)
REPRODUCTION
title_short Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
title_full Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
title_fullStr Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
title_full_unstemmed Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
title_sort Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle
dc.creator.none.fl_str_mv Ayala, Carolina
Pennacchio, Gisela Erika
Soaje, Marta
Carreño, Norma Beatriz
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, Maria Esther
Valdez, Susana Ruth
author Ayala, Carolina
author_facet Ayala, Carolina
Pennacchio, Gisela Erika
Soaje, Marta
Carreño, Norma Beatriz
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, Maria Esther
Valdez, Susana Ruth
author_role author
author2 Pennacchio, Gisela Erika
Soaje, Marta
Carreño, Norma Beatriz
Bittencourt, Jakson Cioni
Jahn, Graciela Alma
Celis, Maria Esther
Valdez, Susana Ruth
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ESTROUS CYCLE
HYPERTHYROIDISM
HYPOTHALAMUS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC-ACID-ISOLEUCINE-AMIDE (NEI)
REPRODUCTION
topic ESTROUS CYCLE
HYPERTHYROIDISM
HYPOTHALAMUS
HYPOTHYROIDISM
NEUROPEPTIDE GLUTAMIC-ACID-ISOLEUCINE-AMIDE (NEI)
REPRODUCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Abstract: We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine amide (NEI) concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone (LH), estradiol and progesterone concentrations were measured in control, hypothyroid (hypoT, treated with PTU during 7-9 days) and hyperthyroid (hyperT, L-T4 during 4-7 days) animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon (P-PM), although hypoT rats showed lower values compared to control during proestrus morning (P-AM). Progesterone levels were higher in all groups at P-PM and in the hyperT during diestrus morning (D2). NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus (E) in the peduncular part of the lateral hypothalamus (PLH). They were also reduced by both treatments in the perifornical part of the lateral hypothalamus(PeFLH) during P-PM. Hypothyroidism led to higher NEI concentrations during P-PM in the organum vasculosum of the lamina terminalis and anteroventral periventricular nucleus (OVLT + AVPV). The present results indicate that NEI concentration is regulated in a complex manner by hypoand hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies.
Fil: Ayala, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Instituto de Histología y Embriología de Mendoza Dr. Mario H. Burgos; Argentina. Universidad Nacional de Córdoba; Argentina
Fil: Pennacchio, Gisela Erika. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Soaje, Marta. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; Argentina
Fil: Carreño, Norma Beatriz. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Mendoza. Instituto de Medicina y Bio. Exp. de Cuyo; Argentina
Fil: Bittencourt, Jakson Cioni. Universidade do Sao Paulo. Instituto de Ciencias Biomedicas; Brasil;
Fil: Jahn, Graciela Alma. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Celis, Maria Esther. Universidad Nacional de Cordoba. Facultad de Medicina. Departamento de Medicina. Cat.de Bacteriologia y Virologia Medicas; Argentina
Fil: Valdez, Susana Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Abstract: We previously showed that short-term hypo- and hyperthyroidism induce changes in neuropeptide glutamic-acid-isoleucine amide (NEI) concentrations in discrete brain areas in male rats. To investigate the possible effects of hypo- and hyperthyroidism on NEI concentrations mainly in hypothalamic areas related to reproduction and behavior, female rats were sacrificed at different days of the estrous cycle. Circulating luteinizing hormone (LH), estradiol and progesterone concentrations were measured in control, hypothyroid (hypoT, treated with PTU during 7-9 days) and hyperthyroid (hyperT, L-T4 during 4-7 days) animals. Both treatments blunted the LH surge. Hypo- and hyperthyroidism increased estradiol concentrations during proestrus afternoon (P-PM), although hypoT rats showed lower values compared to control during proestrus morning (P-AM). Progesterone levels were higher in all groups at P-PM and in the hyperT during diestrus morning (D2). NEI concentrations were lower in hypoT rats during the estrous cycle except in estrus (E) in the peduncular part of the lateral hypothalamus (PLH). They were also reduced by both treatments in the perifornical part of the lateral hypothalamus(PeFLH) during P-PM. Hypothyroidism led to higher NEI concentrations during P-PM in the organum vasculosum of the lamina terminalis and anteroventral periventricular nucleus (OVLT + AVPV). The present results indicate that NEI concentration is regulated in a complex manner by hypoand hyperthyroidism in the different areas studied, suggesting a correlation between NEI values and the variations of gonadal steroid levels during estrous cycle. These changes could be, in part, responsible for the alterations observed in the hypothalamic-pituitary-gonadal axis in these pathologies.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/1547
Ayala, Carolina; Pennacchio, Gisela Erika; Soaje, Marta; Carreño, Norma Beatriz; Bittencourt, Jakson Cioni; et al.; Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle; Elsevier Science Inc; Peptides; 49; 9-2013; 74-80
0196-9781
url http://hdl.handle.net/11336/1547
identifier_str_mv Ayala, Carolina; Pennacchio, Gisela Erika; Soaje, Marta; Carreño, Norma Beatriz; Bittencourt, Jakson Cioni; et al.; Effects of thyroid status on NEI concentration in specific brain areas related to reproduction during the estrous cycle; Elsevier Science Inc; Peptides; 49; 9-2013; 74-80
0196-9781
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.peptides.2013.08.016
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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