Neuroprotection in Synaptic Signalling During Neurological Disorders

Autores
Otero losada, Matilde Estela; Wandosell, Francisco G.; Capani, Francisco
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Some of the most devastating and costly conditions in the world arise from neurological andneurodegenerative disorders. About one-third of the world's population suffers from neurologicaldiseases, including Parkinson's (PD) and Alzheimer's (AD) diseases, multiple sclerosis, epilepsy, spinal cord injury, and others. Symptoms may show early in childhood or substantially delayedin adolescence or young adulthood. Animal models are powerful tools aiding in understandingneurological pathophysiology towards developing neuroprotective strategies.So far, there are no well-established treatments for brain repair. Hence, neuroprotectionbecomes imperative. Synapses pose major targets for finding new neuroprotective agents.The aimof this topic is to share research addressing neuroprotective strategies for the brain, theirpossible pathways, and the use of pharmacological analogues. Four reviews are about hypoxia. Twochapters address themolecular bases of cognitive impairment in AD. Biochemical and physiologicalaspects of neuroprotective agents focusing on synaptic modifications, neuroprotection followingperinatal asphyxia, and pharmacological- and genetic-targeting strategies for Alzheimer's and Parkinson's diseases are reviewed.
Fil: Otero losada, Matilde Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina
Fil: Wandosell, Francisco G.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Materia
Neuroprotection
rats
hipocampo
cns
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/166054
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Neuroprotection in Synaptic Signalling During Neurological DisordersOtero losada, Matilde EstelaWandosell, Francisco G.Capani, FranciscoNeuroprotectionratshipocampocnshttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Some of the most devastating and costly conditions in the world arise from neurological andneurodegenerative disorders. About one-third of the world's population suffers from neurologicaldiseases, including Parkinson's (PD) and Alzheimer's (AD) diseases, multiple sclerosis, epilepsy, spinal cord injury, and others. Symptoms may show early in childhood or substantially delayedin adolescence or young adulthood. Animal models are powerful tools aiding in understandingneurological pathophysiology towards developing neuroprotective strategies.So far, there are no well-established treatments for brain repair. Hence, neuroprotectionbecomes imperative. Synapses pose major targets for finding new neuroprotective agents.The aimof this topic is to share research addressing neuroprotective strategies for the brain, theirpossible pathways, and the use of pharmacological analogues. Four reviews are about hypoxia. Twochapters address themolecular bases of cognitive impairment in AD. Biochemical and physiologicalaspects of neuroprotective agents focusing on synaptic modifications, neuroprotection followingperinatal asphyxia, and pharmacological- and genetic-targeting strategies for Alzheimer's and Parkinson's diseases are reviewed.Fil: Otero losada, Matilde Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; ArgentinaFil: Wandosell, Francisco G.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFrontiers Media2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/166054Otero losada, Matilde Estela; Wandosell, Francisco G.; Capani, Francisco; Neuroprotection in Synaptic Signalling During Neurological Disorders; Frontiers Media; Frontiers in synaptic neuroscience; 13; 746487; 6-2021; 1-31663-3563CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnsyn.2021.746487/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fnsyn.2021.746487info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:37:19Zoai:ri.conicet.gov.ar:11336/166054instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:37:19.66CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neuroprotection in Synaptic Signalling During Neurological Disorders
title Neuroprotection in Synaptic Signalling During Neurological Disorders
spellingShingle Neuroprotection in Synaptic Signalling During Neurological Disorders
Otero losada, Matilde Estela
Neuroprotection
rats
hipocampo
cns
title_short Neuroprotection in Synaptic Signalling During Neurological Disorders
title_full Neuroprotection in Synaptic Signalling During Neurological Disorders
title_fullStr Neuroprotection in Synaptic Signalling During Neurological Disorders
title_full_unstemmed Neuroprotection in Synaptic Signalling During Neurological Disorders
title_sort Neuroprotection in Synaptic Signalling During Neurological Disorders
dc.creator.none.fl_str_mv Otero losada, Matilde Estela
Wandosell, Francisco G.
Capani, Francisco
author Otero losada, Matilde Estela
author_facet Otero losada, Matilde Estela
Wandosell, Francisco G.
Capani, Francisco
author_role author
author2 Wandosell, Francisco G.
Capani, Francisco
author2_role author
author
dc.subject.none.fl_str_mv Neuroprotection
rats
hipocampo
cns
topic Neuroprotection
rats
hipocampo
cns
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Some of the most devastating and costly conditions in the world arise from neurological andneurodegenerative disorders. About one-third of the world's population suffers from neurologicaldiseases, including Parkinson's (PD) and Alzheimer's (AD) diseases, multiple sclerosis, epilepsy, spinal cord injury, and others. Symptoms may show early in childhood or substantially delayedin adolescence or young adulthood. Animal models are powerful tools aiding in understandingneurological pathophysiology towards developing neuroprotective strategies.So far, there are no well-established treatments for brain repair. Hence, neuroprotectionbecomes imperative. Synapses pose major targets for finding new neuroprotective agents.The aimof this topic is to share research addressing neuroprotective strategies for the brain, theirpossible pathways, and the use of pharmacological analogues. Four reviews are about hypoxia. Twochapters address themolecular bases of cognitive impairment in AD. Biochemical and physiologicalaspects of neuroprotective agents focusing on synaptic modifications, neuroprotection followingperinatal asphyxia, and pharmacological- and genetic-targeting strategies for Alzheimer's and Parkinson's diseases are reviewed.
Fil: Otero losada, Matilde Estela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina. Universidad Abierta Interamericana. Secretaría de Investigación. Centro de Altos Estudios En Ciencias Humanas y de la Salud - Sede Buenos Aires; Argentina
Fil: Wandosell, Francisco G.. Universidad Autónoma de Madrid; España. Consejo Superior de Investigaciones Científicas; España
Fil: Capani, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
description Some of the most devastating and costly conditions in the world arise from neurological andneurodegenerative disorders. About one-third of the world's population suffers from neurologicaldiseases, including Parkinson's (PD) and Alzheimer's (AD) diseases, multiple sclerosis, epilepsy, spinal cord injury, and others. Symptoms may show early in childhood or substantially delayedin adolescence or young adulthood. Animal models are powerful tools aiding in understandingneurological pathophysiology towards developing neuroprotective strategies.So far, there are no well-established treatments for brain repair. Hence, neuroprotectionbecomes imperative. Synapses pose major targets for finding new neuroprotective agents.The aimof this topic is to share research addressing neuroprotective strategies for the brain, theirpossible pathways, and the use of pharmacological analogues. Four reviews are about hypoxia. Twochapters address themolecular bases of cognitive impairment in AD. Biochemical and physiologicalaspects of neuroprotective agents focusing on synaptic modifications, neuroprotection followingperinatal asphyxia, and pharmacological- and genetic-targeting strategies for Alzheimer's and Parkinson's diseases are reviewed.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/166054
Otero losada, Matilde Estela; Wandosell, Francisco G.; Capani, Francisco; Neuroprotection in Synaptic Signalling During Neurological Disorders; Frontiers Media; Frontiers in synaptic neuroscience; 13; 746487; 6-2021; 1-3
1663-3563
CONICET Digital
CONICET
url http://hdl.handle.net/11336/166054
identifier_str_mv Otero losada, Matilde Estela; Wandosell, Francisco G.; Capani, Francisco; Neuroprotection in Synaptic Signalling During Neurological Disorders; Frontiers Media; Frontiers in synaptic neuroscience; 13; 746487; 6-2021; 1-3
1663-3563
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fnsyn.2021.746487/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fnsyn.2021.746487
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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