Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes
- Autores
- Peros, Ivan Gabriel; Cerrudo, Carolina Susana; Pilloff, Marcela Gabriela; Belaich, Mariano Nicolas; Lozano, Mario Enrique; Ghiringhelli, Pablo Daniel
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Baculoviruses are a group of insect viruses with large circular dsDNA genomes exploited in numerous biotechnological applications, such as the biological control of agricultural pests, the expression of recombinant proteins or the gene delivery of therapeutic sequences in mammals, among others. Their genomes encode between 80 and 200 proteins, of which 38 are shared by all reported species. Thanks to multi-omic studies, there is remarkable information about the baculoviral proteome and the temporality in the virus gene expression. This allows some functional elements of the genome to be very well described, such as promoters and open reading frames. However, less information is available about the transcription termination signals and, consequently, there are still imprecisions about what are the limits of the transcriptional units present in the baculovirus genomes and how is the processing of the 3´ end of viral mRNA. Regarding to this, in this review we provide an update about the characteristics of DNA signals involved in this process and we contribute to their correct prediction through an exhaustive analysis that involves bibliography information, data mining, RNA structure and a comprehensive study of the core gene 3´ ends from 180 baculovirus genomes.
Fil: Peros, Ivan Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina
Fil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina
Fil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina
Fil: Belaich, Mariano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina
Fil: Lozano, Mario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina
Fil: Ghiringhelli, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina - Materia
-
BACULOVIRIDAE
MRNA
PATTERN-SEARCHING
POLYADENYLATION PROCESS
RNA STRUCTURE - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/156908
Ver los metadatos del registro completo
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Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus GenesPeros, Ivan GabrielCerrudo, Carolina SusanaPilloff, Marcela GabrielaBelaich, Mariano NicolasLozano, Mario EnriqueGhiringhelli, Pablo DanielBACULOVIRIDAEMRNAPATTERN-SEARCHINGPOLYADENYLATION PROCESSRNA STRUCTUREhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Baculoviruses are a group of insect viruses with large circular dsDNA genomes exploited in numerous biotechnological applications, such as the biological control of agricultural pests, the expression of recombinant proteins or the gene delivery of therapeutic sequences in mammals, among others. Their genomes encode between 80 and 200 proteins, of which 38 are shared by all reported species. Thanks to multi-omic studies, there is remarkable information about the baculoviral proteome and the temporality in the virus gene expression. This allows some functional elements of the genome to be very well described, such as promoters and open reading frames. However, less information is available about the transcription termination signals and, consequently, there are still imprecisions about what are the limits of the transcriptional units present in the baculovirus genomes and how is the processing of the 3´ end of viral mRNA. Regarding to this, in this review we provide an update about the characteristics of DNA signals involved in this process and we contribute to their correct prediction through an exhaustive analysis that involves bibliography information, data mining, RNA structure and a comprehensive study of the core gene 3´ ends from 180 baculovirus genomes.Fil: Peros, Ivan Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaFil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaFil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; ArgentinaFil: Belaich, Mariano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaFil: Lozano, Mario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; ArgentinaFil: Ghiringhelli, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; ArgentinaMultidisciplinary Digital Publishing Institute2020-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/156908Peros, Ivan Gabriel; Cerrudo, Carolina Susana; Pilloff, Marcela Gabriela; Belaich, Mariano Nicolas; Lozano, Mario Enrique; et al.; Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes; Multidisciplinary Digital Publishing Institute; Viruses; 12; 12; 12-2020; 1-261999-4915CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3390/v12121395info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/12/12/1395info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:20:27Zoai:ri.conicet.gov.ar:11336/156908instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:20:27.556CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
title |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
spellingShingle |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes Peros, Ivan Gabriel BACULOVIRIDAE MRNA PATTERN-SEARCHING POLYADENYLATION PROCESS RNA STRUCTURE |
title_short |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
title_full |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
title_fullStr |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
title_full_unstemmed |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
title_sort |
Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes |
dc.creator.none.fl_str_mv |
Peros, Ivan Gabriel Cerrudo, Carolina Susana Pilloff, Marcela Gabriela Belaich, Mariano Nicolas Lozano, Mario Enrique Ghiringhelli, Pablo Daniel |
author |
Peros, Ivan Gabriel |
author_facet |
Peros, Ivan Gabriel Cerrudo, Carolina Susana Pilloff, Marcela Gabriela Belaich, Mariano Nicolas Lozano, Mario Enrique Ghiringhelli, Pablo Daniel |
author_role |
author |
author2 |
Cerrudo, Carolina Susana Pilloff, Marcela Gabriela Belaich, Mariano Nicolas Lozano, Mario Enrique Ghiringhelli, Pablo Daniel |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
BACULOVIRIDAE MRNA PATTERN-SEARCHING POLYADENYLATION PROCESS RNA STRUCTURE |
topic |
BACULOVIRIDAE MRNA PATTERN-SEARCHING POLYADENYLATION PROCESS RNA STRUCTURE |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Baculoviruses are a group of insect viruses with large circular dsDNA genomes exploited in numerous biotechnological applications, such as the biological control of agricultural pests, the expression of recombinant proteins or the gene delivery of therapeutic sequences in mammals, among others. Their genomes encode between 80 and 200 proteins, of which 38 are shared by all reported species. Thanks to multi-omic studies, there is remarkable information about the baculoviral proteome and the temporality in the virus gene expression. This allows some functional elements of the genome to be very well described, such as promoters and open reading frames. However, less information is available about the transcription termination signals and, consequently, there are still imprecisions about what are the limits of the transcriptional units present in the baculovirus genomes and how is the processing of the 3´ end of viral mRNA. Regarding to this, in this review we provide an update about the characteristics of DNA signals involved in this process and we contribute to their correct prediction through an exhaustive analysis that involves bibliography information, data mining, RNA structure and a comprehensive study of the core gene 3´ ends from 180 baculovirus genomes. Fil: Peros, Ivan Gabriel. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina Fil: Cerrudo, Carolina Susana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina Fil: Pilloff, Marcela Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina Fil: Belaich, Mariano Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina Fil: Lozano, Mario Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular. Área de Virosis Emergentes y Zoonótica; Argentina Fil: Ghiringhelli, Pablo Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Ingeniería Genética y Biología Molecular y Celular; Argentina |
description |
Baculoviruses are a group of insect viruses with large circular dsDNA genomes exploited in numerous biotechnological applications, such as the biological control of agricultural pests, the expression of recombinant proteins or the gene delivery of therapeutic sequences in mammals, among others. Their genomes encode between 80 and 200 proteins, of which 38 are shared by all reported species. Thanks to multi-omic studies, there is remarkable information about the baculoviral proteome and the temporality in the virus gene expression. This allows some functional elements of the genome to be very well described, such as promoters and open reading frames. However, less information is available about the transcription termination signals and, consequently, there are still imprecisions about what are the limits of the transcriptional units present in the baculovirus genomes and how is the processing of the 3´ end of viral mRNA. Regarding to this, in this review we provide an update about the characteristics of DNA signals involved in this process and we contribute to their correct prediction through an exhaustive analysis that involves bibliography information, data mining, RNA structure and a comprehensive study of the core gene 3´ ends from 180 baculovirus genomes. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/156908 Peros, Ivan Gabriel; Cerrudo, Carolina Susana; Pilloff, Marcela Gabriela; Belaich, Mariano Nicolas; Lozano, Mario Enrique; et al.; Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes; Multidisciplinary Digital Publishing Institute; Viruses; 12; 12; 12-2020; 1-26 1999-4915 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/156908 |
identifier_str_mv |
Peros, Ivan Gabriel; Cerrudo, Carolina Susana; Pilloff, Marcela Gabriela; Belaich, Mariano Nicolas; Lozano, Mario Enrique; et al.; Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes; Multidisciplinary Digital Publishing Institute; Viruses; 12; 12; 12-2020; 1-26 1999-4915 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.3390/v12121395 info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1999-4915/12/12/1395 |
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openAccess |
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https://creativecommons.org/licenses/by/2.5/ar/ |
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application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
publisher.none.fl_str_mv |
Multidisciplinary Digital Publishing Institute |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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