Meta-analysis of Chromatin Programming by Steroid Receptors

• Autores: Paakinaho, Ville; Swinstead, Erin E.; Presman, Diego Martin; Grøntved, Lars; Hager, Gordon L.
• Año de publicación: 2019
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: CHROMATIN; CHROMATIN REMODELERS; DYNAMIC ASSISTED LOADING; FOXA1; PIONEER FACTORS; STEROID RECEPTORS; TRANSCRIPTION FACTORS
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Transcription factors (TFs) must access chromatin to bind to their response elements and regulate gene expression. A widely accepted model proposes that only a special subset of TFs, pioneer factors, can associate with condensed chromatin and initiate chromatin opening. We previously reported that steroid receptors (SRs), not considered pioneer factors, can assist the binding of an archetypal pioneer, the forkhead box protein 1 (FOXA1), at a subset of receptor-activated enhancers. These findings have been challenged recently, with the suggestion that newly acquired data fully support the prevailing pioneer model. Here, we reexamine our results and confirm the original conclusions. We also analyze and discuss a number of available datasets relevant to chromatin penetration by SRs and find a general consensus supporting our original observations. Hence, we propose that chromatin opening at some sites can be initiated by SRs, with a parallel recruitment of factors often treated as having a unique pioneer function.
Fil: Paakinaho, Ville. University Of Eastern Finland.; Finlandia
Fil: Swinstead, Erin E.. National Cancer Institute; Estados Unidos
Fil: Presman, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Grøntved, Lars. Technical University of Denmark; Dinamarca
Fil: Hager, Gordon L.. National Cancer Institute; Estados Unidos