Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders

Autores
Coll-Bonfill, N.; de la Cruz Thea, Benjamín Isaías; Pisano, María Victoria; Musri, Melina Mara
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Vascular smooth muscle cells (SMC) are a highly specialized cell type that exhibit extraordinary plasticity in adult animals in response to a number of environmental cues. Upon vascular injury, SMC undergo phenotypic switch from a contractile-differentiated to a proliferative/migratory-dedifferentiated phenotype. This process plays a major role in vascular lesion formation and during the development of vascular remodeling. Vascular remodeling comprises the accumulation of dedifferentiated SMC in the intima of arteries and is central to a number of vascular diseases such as arteriosclerosis, chronic obstructive pulmonary disease or pulmonary hypertension. Therefore, it is critical to understand the molecular mechanisms that govern SMC phenotype. In the last decade, a number of new classes of noncoding RNAs have been described. These molecules have emerged as key factors controlling tissue homeostasis during physiological and pathological conditions. In this review, we will discuss the role of noncoding RNAs, including microRNAs and long noncoding RNAs, in the regulation of SMC plasticity.
Fil: Coll-Bonfill, N.. Universidad de Barcelona; España
Fil: de la Cruz Thea, Benjamín Isaías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pisano, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Musri, Melina Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
LNCRNAS
MIRNAS
NONCODING RNAS
PHENOTYPIC CHANGE
SMOOTH MUSCLE CELLS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/185956
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disordersColl-Bonfill, N.de la Cruz Thea, Benjamín IsaíasPisano, María VictoriaMusri, Melina MaraLNCRNASMIRNASNONCODING RNASPHENOTYPIC CHANGESMOOTH MUSCLE CELLShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Vascular smooth muscle cells (SMC) are a highly specialized cell type that exhibit extraordinary plasticity in adult animals in response to a number of environmental cues. Upon vascular injury, SMC undergo phenotypic switch from a contractile-differentiated to a proliferative/migratory-dedifferentiated phenotype. This process plays a major role in vascular lesion formation and during the development of vascular remodeling. Vascular remodeling comprises the accumulation of dedifferentiated SMC in the intima of arteries and is central to a number of vascular diseases such as arteriosclerosis, chronic obstructive pulmonary disease or pulmonary hypertension. Therefore, it is critical to understand the molecular mechanisms that govern SMC phenotype. In the last decade, a number of new classes of noncoding RNAs have been described. These molecules have emerged as key factors controlling tissue homeostasis during physiological and pathological conditions. In this review, we will discuss the role of noncoding RNAs, including microRNAs and long noncoding RNAs, in the regulation of SMC plasticity.Fil: Coll-Bonfill, N.. Universidad de Barcelona; EspañaFil: de la Cruz Thea, Benjamín Isaías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Pisano, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Musri, Melina Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaSpringer2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/185956Coll-Bonfill, N.; de la Cruz Thea, Benjamín Isaías; Pisano, María Victoria; Musri, Melina Mara; Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders; Springer; Pflugers Archiv-European Journal of Physiology; 468; 6; 6-2016; 1071-10870031-67681432-2013CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/27109570info:eu-repo/semantics/altIdentifier/doi/10.1007/s00424-016-1821-xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:52:06Zoai:ri.conicet.gov.ar:11336/185956instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:52:06.563CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
title Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
spellingShingle Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
Coll-Bonfill, N.
LNCRNAS
MIRNAS
NONCODING RNAS
PHENOTYPIC CHANGE
SMOOTH MUSCLE CELLS
title_short Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
title_full Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
title_fullStr Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
title_full_unstemmed Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
title_sort Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders
dc.creator.none.fl_str_mv Coll-Bonfill, N.
de la Cruz Thea, Benjamín Isaías
Pisano, María Victoria
Musri, Melina Mara
author Coll-Bonfill, N.
author_facet Coll-Bonfill, N.
de la Cruz Thea, Benjamín Isaías
Pisano, María Victoria
Musri, Melina Mara
author_role author
author2 de la Cruz Thea, Benjamín Isaías
Pisano, María Victoria
Musri, Melina Mara
author2_role author
author
author
dc.subject.none.fl_str_mv LNCRNAS
MIRNAS
NONCODING RNAS
PHENOTYPIC CHANGE
SMOOTH MUSCLE CELLS
topic LNCRNAS
MIRNAS
NONCODING RNAS
PHENOTYPIC CHANGE
SMOOTH MUSCLE CELLS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Vascular smooth muscle cells (SMC) are a highly specialized cell type that exhibit extraordinary plasticity in adult animals in response to a number of environmental cues. Upon vascular injury, SMC undergo phenotypic switch from a contractile-differentiated to a proliferative/migratory-dedifferentiated phenotype. This process plays a major role in vascular lesion formation and during the development of vascular remodeling. Vascular remodeling comprises the accumulation of dedifferentiated SMC in the intima of arteries and is central to a number of vascular diseases such as arteriosclerosis, chronic obstructive pulmonary disease or pulmonary hypertension. Therefore, it is critical to understand the molecular mechanisms that govern SMC phenotype. In the last decade, a number of new classes of noncoding RNAs have been described. These molecules have emerged as key factors controlling tissue homeostasis during physiological and pathological conditions. In this review, we will discuss the role of noncoding RNAs, including microRNAs and long noncoding RNAs, in the regulation of SMC plasticity.
Fil: Coll-Bonfill, N.. Universidad de Barcelona; España
Fil: de la Cruz Thea, Benjamín Isaías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Pisano, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Musri, Melina Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Vascular smooth muscle cells (SMC) are a highly specialized cell type that exhibit extraordinary plasticity in adult animals in response to a number of environmental cues. Upon vascular injury, SMC undergo phenotypic switch from a contractile-differentiated to a proliferative/migratory-dedifferentiated phenotype. This process plays a major role in vascular lesion formation and during the development of vascular remodeling. Vascular remodeling comprises the accumulation of dedifferentiated SMC in the intima of arteries and is central to a number of vascular diseases such as arteriosclerosis, chronic obstructive pulmonary disease or pulmonary hypertension. Therefore, it is critical to understand the molecular mechanisms that govern SMC phenotype. In the last decade, a number of new classes of noncoding RNAs have been described. These molecules have emerged as key factors controlling tissue homeostasis during physiological and pathological conditions. In this review, we will discuss the role of noncoding RNAs, including microRNAs and long noncoding RNAs, in the regulation of SMC plasticity.
publishDate 2016
dc.date.none.fl_str_mv 2016-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/185956
Coll-Bonfill, N.; de la Cruz Thea, Benjamín Isaías; Pisano, María Victoria; Musri, Melina Mara; Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders; Springer; Pflugers Archiv-European Journal of Physiology; 468; 6; 6-2016; 1071-1087
0031-6768
1432-2013
CONICET Digital
CONICET
url http://hdl.handle.net/11336/185956
identifier_str_mv Coll-Bonfill, N.; de la Cruz Thea, Benjamín Isaías; Pisano, María Victoria; Musri, Melina Mara; Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders; Springer; Pflugers Archiv-European Journal of Physiology; 468; 6; 6-2016; 1071-1087
0031-6768
1432-2013
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/27109570
info:eu-repo/semantics/altIdentifier/doi/10.1007/s00424-016-1821-x
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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