The Role of MicroRNAs in HIV Infection

Autores
Morando, Nicolás; Rosenzvit, Mara Cecilia; Pando, María de los Ángeles; Allmer, Jens
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
MicroRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in regulatinggene expression at the post-transcriptional level. These regulatory molecules are integral to manybiological processes and have been implicated in the pathogenesis of various diseases, includingHuman Immunodeficiency Virus (HIV) infection. This review aims to cover the current understandingof the multifaceted roles miRNAs assume in the context of HIV infection and pathogenesis. Thediscourse is structured around three primary focal points: (i) elucidation of the mechanisms throughwhich miRNAs regulate HIV replication, encompassing both direct targeting of viral transcripts andindirect modulation of host factors critical for viral replication; (ii) examination of the modulationof miRNA expression by HIV, mediated through either viral proteins or the activation of cellularpathways consequent to viral infection; and (iii) assessment of the impact of miRNAs on the immuneresponse and the progression of disease in HIV-infected individuals. Further, this review delves intothe potential utility of miRNAs as biomarkers and therapeutic agents in HIV infection, underscoringthe challenges and prospects inherent to this line of inquiry. The synthesis of current evidencepositions miRNAs as significant modulators of the host-virus interplay, offering promising avenuesfor enhancing the diagnosis, treatment, and prevention of HIV infection.
Fil: Morando, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Allmer, Jens. University Of Applied Sciences. Hochschule Esslingen; Alemania
Materia
MicroRNAs
HIV
HIV miRNAs
MicroRNA regulation
miRNA diagnostics
miRNA therapeutics
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238507
Acceder
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spelling The Role of MicroRNAs in HIV InfectionMorando, NicolásRosenzvit, Mara CeciliaPando, María de los ÁngelesAllmer, JensMicroRNAsHIVHIV miRNAsMicroRNA regulationmiRNA diagnosticsmiRNA therapeuticshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3MicroRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in regulatinggene expression at the post-transcriptional level. These regulatory molecules are integral to manybiological processes and have been implicated in the pathogenesis of various diseases, includingHuman Immunodeficiency Virus (HIV) infection. This review aims to cover the current understandingof the multifaceted roles miRNAs assume in the context of HIV infection and pathogenesis. Thediscourse is structured around three primary focal points: (i) elucidation of the mechanisms throughwhich miRNAs regulate HIV replication, encompassing both direct targeting of viral transcripts andindirect modulation of host factors critical for viral replication; (ii) examination of the modulationof miRNA expression by HIV, mediated through either viral proteins or the activation of cellularpathways consequent to viral infection; and (iii) assessment of the impact of miRNAs on the immuneresponse and the progression of disease in HIV-infected individuals. Further, this review delves intothe potential utility of miRNAs as biomarkers and therapeutic agents in HIV infection, underscoringthe challenges and prospects inherent to this line of inquiry. The synthesis of current evidencepositions miRNAs as significant modulators of the host-virus interplay, offering promising avenuesfor enhancing the diagnosis, treatment, and prevention of HIV infection.Fil: Morando, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Allmer, Jens. University Of Applied Sciences. Hochschule Esslingen; AlemaniaMDPI2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238507Morando, Nicolás; Rosenzvit, Mara Cecilia; Pando, María de los Ángeles; Allmer, Jens; The Role of MicroRNAs in HIV Infection; MDPI; Genes; 15; 5; 4-2024; 1-232073-4425CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/38790203/info:eu-repo/semantics/altIdentifier/doi/10.3390/genes15050574info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:57Zoai:ri.conicet.gov.ar:11336/238507instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:58.054CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Role of MicroRNAs in HIV Infection
title The Role of MicroRNAs in HIV Infection
spellingShingle The Role of MicroRNAs in HIV Infection
Morando, Nicolás
MicroRNAs
HIV
HIV miRNAs
MicroRNA regulation
miRNA diagnostics
miRNA therapeutics
title_short The Role of MicroRNAs in HIV Infection
title_full The Role of MicroRNAs in HIV Infection
title_fullStr The Role of MicroRNAs in HIV Infection
title_full_unstemmed The Role of MicroRNAs in HIV Infection
title_sort The Role of MicroRNAs in HIV Infection
dc.creator.none.fl_str_mv Morando, Nicolás
Rosenzvit, Mara Cecilia
Pando, María de los Ángeles
Allmer, Jens
author Morando, Nicolás
author_facet Morando, Nicolás
Rosenzvit, Mara Cecilia
Pando, María de los Ángeles
Allmer, Jens
author_role author
author2 Rosenzvit, Mara Cecilia
Pando, María de los Ángeles
Allmer, Jens
author2_role author
author
author
dc.subject.none.fl_str_mv MicroRNAs
HIV
HIV miRNAs
MicroRNA regulation
miRNA diagnostics
miRNA therapeutics
topic MicroRNAs
HIV
HIV miRNAs
MicroRNA regulation
miRNA diagnostics
miRNA therapeutics
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv MicroRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in regulatinggene expression at the post-transcriptional level. These regulatory molecules are integral to manybiological processes and have been implicated in the pathogenesis of various diseases, includingHuman Immunodeficiency Virus (HIV) infection. This review aims to cover the current understandingof the multifaceted roles miRNAs assume in the context of HIV infection and pathogenesis. Thediscourse is structured around three primary focal points: (i) elucidation of the mechanisms throughwhich miRNAs regulate HIV replication, encompassing both direct targeting of viral transcripts andindirect modulation of host factors critical for viral replication; (ii) examination of the modulationof miRNA expression by HIV, mediated through either viral proteins or the activation of cellularpathways consequent to viral infection; and (iii) assessment of the impact of miRNAs on the immuneresponse and the progression of disease in HIV-infected individuals. Further, this review delves intothe potential utility of miRNAs as biomarkers and therapeutic agents in HIV infection, underscoringthe challenges and prospects inherent to this line of inquiry. The synthesis of current evidencepositions miRNAs as significant modulators of the host-virus interplay, offering promising avenuesfor enhancing the diagnosis, treatment, and prevention of HIV infection.
Fil: Morando, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Rosenzvit, Mara Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Pando, María de los Ángeles. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Allmer, Jens. University Of Applied Sciences. Hochschule Esslingen; Alemania
description MicroRNAs (miRNAs), a class of small, non-coding RNAs, play a pivotal role in regulatinggene expression at the post-transcriptional level. These regulatory molecules are integral to manybiological processes and have been implicated in the pathogenesis of various diseases, includingHuman Immunodeficiency Virus (HIV) infection. This review aims to cover the current understandingof the multifaceted roles miRNAs assume in the context of HIV infection and pathogenesis. Thediscourse is structured around three primary focal points: (i) elucidation of the mechanisms throughwhich miRNAs regulate HIV replication, encompassing both direct targeting of viral transcripts andindirect modulation of host factors critical for viral replication; (ii) examination of the modulationof miRNA expression by HIV, mediated through either viral proteins or the activation of cellularpathways consequent to viral infection; and (iii) assessment of the impact of miRNAs on the immuneresponse and the progression of disease in HIV-infected individuals. Further, this review delves intothe potential utility of miRNAs as biomarkers and therapeutic agents in HIV infection, underscoringthe challenges and prospects inherent to this line of inquiry. The synthesis of current evidencepositions miRNAs as significant modulators of the host-virus interplay, offering promising avenuesfor enhancing the diagnosis, treatment, and prevention of HIV infection.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238507
Morando, Nicolás; Rosenzvit, Mara Cecilia; Pando, María de los Ángeles; Allmer, Jens; The Role of MicroRNAs in HIV Infection; MDPI; Genes; 15; 5; 4-2024; 1-23
2073-4425
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238507
identifier_str_mv Morando, Nicolás; Rosenzvit, Mara Cecilia; Pando, María de los Ángeles; Allmer, Jens; The Role of MicroRNAs in HIV Infection; MDPI; Genes; 15; 5; 4-2024; 1-23
2073-4425
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/38790203/
info:eu-repo/semantics/altIdentifier/doi/10.3390/genes15050574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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