Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation

Autores
Duarte, Jairo; Vinderola, Celso Gabriel; Ritz, Barry; Perdigón, Gabriela; Matar, Chantal
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Dietary proteins harbour bioactive peptides that can be released by a fermentation process. Fish proteins are a valuable and little-exploited source of potentially active biopeptides. The aim of this research was to evaluate the effects of a commercially available fermented fish protein concentrate (Seacure®) (FPC) derived from a fermentation process, on the mucosal immune response in a murine model. BALB/c mice received the FPC or the non-fermented powder at different concentrations (0.20, 0.25 or 0.30 mg/ml) for 2, 5 or 7 consecutive days. At the end of each feeding period, histological studies of the gut were carried out and the phagocytic activity of peritoneal macrophages, the number of IgA+ cells in the small intestine lamina propria and bronchial tissue and the number of IL-4+, IL-6+, IL-10+, IFNγ+ and TNFα+ cells in the small intestine lamina propria were determined. Different accumulative doses of FPC did not induce any inflammatory immune response and the normal morphology of the small intestine was not affected. Phagocytic activity of peritoneal macrophages was enhanced following FPC administration at 0.3 mg/ml for 7 consecutive days. The number of IgA+ cells increased in the small intestine lamina propria but not in the bronchial tissue. IL-4, IL-6 and IL-10 were all significantly increased in the lamina propria of the small intestine of animals that received FPC. At the same time, some pro-inflammatory cytokines such as IFNγ and TNFα also increased, but the intestinal homoeostasis was maintained and no tissue damage was observed. We conclude that FPC is an immunomodulating food with a demonstrated capacity to enhance non-specific host defense mechanisms. © 2006 Elsevier GmbH. All rights reserved.
Fil: Duarte, Jairo. Universite de Moncton; Canadá
Fil: Vinderola, Celso Gabriel. Universite de Moncton; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Ritz, Barry. Proper Nutrition; Estados Unidos
Fil: Perdigón, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Matar, Chantal. Universite de Moncton; Canadá
Materia
Fish Proteins
Immunomodulation
Intestinal Mucosa
Peptides
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/36577

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network_name_str CONICET Digital (CONICET)
spelling Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementationDuarte, JairoVinderola, Celso GabrielRitz, BarryPerdigón, GabrielaMatar, ChantalFish ProteinsImmunomodulationIntestinal MucosaPeptideshttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2Dietary proteins harbour bioactive peptides that can be released by a fermentation process. Fish proteins are a valuable and little-exploited source of potentially active biopeptides. The aim of this research was to evaluate the effects of a commercially available fermented fish protein concentrate (Seacure®) (FPC) derived from a fermentation process, on the mucosal immune response in a murine model. BALB/c mice received the FPC or the non-fermented powder at different concentrations (0.20, 0.25 or 0.30 mg/ml) for 2, 5 or 7 consecutive days. At the end of each feeding period, histological studies of the gut were carried out and the phagocytic activity of peritoneal macrophages, the number of IgA+ cells in the small intestine lamina propria and bronchial tissue and the number of IL-4+, IL-6+, IL-10+, IFNγ+ and TNFα+ cells in the small intestine lamina propria were determined. Different accumulative doses of FPC did not induce any inflammatory immune response and the normal morphology of the small intestine was not affected. Phagocytic activity of peritoneal macrophages was enhanced following FPC administration at 0.3 mg/ml for 7 consecutive days. The number of IgA+ cells increased in the small intestine lamina propria but not in the bronchial tissue. IL-4, IL-6 and IL-10 were all significantly increased in the lamina propria of the small intestine of animals that received FPC. At the same time, some pro-inflammatory cytokines such as IFNγ and TNFα also increased, but the intestinal homoeostasis was maintained and no tissue damage was observed. We conclude that FPC is an immunomodulating food with a demonstrated capacity to enhance non-specific host defense mechanisms. © 2006 Elsevier GmbH. All rights reserved.Fil: Duarte, Jairo. Universite de Moncton; CanadáFil: Vinderola, Celso Gabriel. Universite de Moncton; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; ArgentinaFil: Ritz, Barry. Proper Nutrition; Estados UnidosFil: Perdigón, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Facultad de Bioquímica, Química y Farmacia; ArgentinaFil: Matar, Chantal. Universite de Moncton; CanadáElsevier Gmbh2006-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/36577Duarte, Jairo; Vinderola, Celso Gabriel; Ritz, Barry; Perdigón, Gabriela; Matar, Chantal; Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation; Elsevier Gmbh; Immunobiology; 211; 5; 6-2006; 341-3500171-2985CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.imbio.2005.12.002info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171298506000362info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:44:49Zoai:ri.conicet.gov.ar:11336/36577instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:44:49.33CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
title Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
spellingShingle Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
Duarte, Jairo
Fish Proteins
Immunomodulation
Intestinal Mucosa
Peptides
title_short Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
title_full Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
title_fullStr Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
title_full_unstemmed Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
title_sort Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation
dc.creator.none.fl_str_mv Duarte, Jairo
Vinderola, Celso Gabriel
Ritz, Barry
Perdigón, Gabriela
Matar, Chantal
author Duarte, Jairo
author_facet Duarte, Jairo
Vinderola, Celso Gabriel
Ritz, Barry
Perdigón, Gabriela
Matar, Chantal
author_role author
author2 Vinderola, Celso Gabriel
Ritz, Barry
Perdigón, Gabriela
Matar, Chantal
author2_role author
author
author
author
dc.subject.none.fl_str_mv Fish Proteins
Immunomodulation
Intestinal Mucosa
Peptides
topic Fish Proteins
Immunomodulation
Intestinal Mucosa
Peptides
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Dietary proteins harbour bioactive peptides that can be released by a fermentation process. Fish proteins are a valuable and little-exploited source of potentially active biopeptides. The aim of this research was to evaluate the effects of a commercially available fermented fish protein concentrate (Seacure®) (FPC) derived from a fermentation process, on the mucosal immune response in a murine model. BALB/c mice received the FPC or the non-fermented powder at different concentrations (0.20, 0.25 or 0.30 mg/ml) for 2, 5 or 7 consecutive days. At the end of each feeding period, histological studies of the gut were carried out and the phagocytic activity of peritoneal macrophages, the number of IgA+ cells in the small intestine lamina propria and bronchial tissue and the number of IL-4+, IL-6+, IL-10+, IFNγ+ and TNFα+ cells in the small intestine lamina propria were determined. Different accumulative doses of FPC did not induce any inflammatory immune response and the normal morphology of the small intestine was not affected. Phagocytic activity of peritoneal macrophages was enhanced following FPC administration at 0.3 mg/ml for 7 consecutive days. The number of IgA+ cells increased in the small intestine lamina propria but not in the bronchial tissue. IL-4, IL-6 and IL-10 were all significantly increased in the lamina propria of the small intestine of animals that received FPC. At the same time, some pro-inflammatory cytokines such as IFNγ and TNFα also increased, but the intestinal homoeostasis was maintained and no tissue damage was observed. We conclude that FPC is an immunomodulating food with a demonstrated capacity to enhance non-specific host defense mechanisms. © 2006 Elsevier GmbH. All rights reserved.
Fil: Duarte, Jairo. Universite de Moncton; Canadá
Fil: Vinderola, Celso Gabriel. Universite de Moncton; Canadá. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina
Fil: Ritz, Barry. Proper Nutrition; Estados Unidos
Fil: Perdigón, Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucuman. Centro de Referencia Para Lactobacilos; Argentina. Facultad de Bioquímica, Química y Farmacia; Argentina
Fil: Matar, Chantal. Universite de Moncton; Canadá
description Dietary proteins harbour bioactive peptides that can be released by a fermentation process. Fish proteins are a valuable and little-exploited source of potentially active biopeptides. The aim of this research was to evaluate the effects of a commercially available fermented fish protein concentrate (Seacure®) (FPC) derived from a fermentation process, on the mucosal immune response in a murine model. BALB/c mice received the FPC or the non-fermented powder at different concentrations (0.20, 0.25 or 0.30 mg/ml) for 2, 5 or 7 consecutive days. At the end of each feeding period, histological studies of the gut were carried out and the phagocytic activity of peritoneal macrophages, the number of IgA+ cells in the small intestine lamina propria and bronchial tissue and the number of IL-4+, IL-6+, IL-10+, IFNγ+ and TNFα+ cells in the small intestine lamina propria were determined. Different accumulative doses of FPC did not induce any inflammatory immune response and the normal morphology of the small intestine was not affected. Phagocytic activity of peritoneal macrophages was enhanced following FPC administration at 0.3 mg/ml for 7 consecutive days. The number of IgA+ cells increased in the small intestine lamina propria but not in the bronchial tissue. IL-4, IL-6 and IL-10 were all significantly increased in the lamina propria of the small intestine of animals that received FPC. At the same time, some pro-inflammatory cytokines such as IFNγ and TNFα also increased, but the intestinal homoeostasis was maintained and no tissue damage was observed. We conclude that FPC is an immunomodulating food with a demonstrated capacity to enhance non-specific host defense mechanisms. © 2006 Elsevier GmbH. All rights reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/36577
Duarte, Jairo; Vinderola, Celso Gabriel; Ritz, Barry; Perdigón, Gabriela; Matar, Chantal; Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation; Elsevier Gmbh; Immunobiology; 211; 5; 6-2006; 341-350
0171-2985
CONICET Digital
CONICET
url http://hdl.handle.net/11336/36577
identifier_str_mv Duarte, Jairo; Vinderola, Celso Gabriel; Ritz, Barry; Perdigón, Gabriela; Matar, Chantal; Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation; Elsevier Gmbh; Immunobiology; 211; 5; 6-2006; 341-350
0171-2985
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.imbio.2005.12.002
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0171298506000362
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Gmbh
publisher.none.fl_str_mv Elsevier Gmbh
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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