Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study

Autores
Kemp, Andrew H.; Rodríguez López, Santiago; Passos, Valeria M. A.; Bittencourt, Marcio S.; Dantas, Eduardo M.; Mill, José G.; Ribeiro, Antonio L. P.; Thayer, Julian F.; Bensenor, Isabela M.; Lotufo, Paulo A.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
Fil: Kemp, Andrew H.. University of Sydney; Australia. Universidade de Sao Paulo; Brasil
Fil: Rodríguez López, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina. University of Sydney; Australia. Universidad Autónoma de Madrid; España
Fil: Passos, Valeria M. A.. Universidade Federal de Minas Gerais; Brasil
Fil: Bittencourt, Marcio S.. Universidade de Sao Paulo; Brasil
Fil: Dantas, Eduardo M.. University of Vale do São Francisco; Brasil
Fil: Mill, José G.. Universidade Federal do Espírito Santo; Brasil
Fil: Ribeiro, Antonio L. P.. Universidade Federal de Minas Gerais; Brasil
Fil: Thayer, Julian F.. Ohio State University; Estados Unidos
Fil: Bensenor, Isabela M.. Universidade de Sao Paulo; Brasil
Fil: Lotufo, Paulo A.. Universidade de Sao Paulo; Brasil
Materia
CAROTID INTIMA-MEDIA THICKNESS
COGNITION
EXECUTIVE FUNCTION
HEART RATE VARIABILITY
HOMA-IR
HOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCE
HRV
IMT
MEDIATION ANALYSES
PATH MODELLING
TMT
TRAIL MAKING TEST
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/85844
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/85844
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling studyKemp, Andrew H.Rodríguez López, SantiagoPassos, Valeria M. A.Bittencourt, Marcio S.Dantas, Eduardo M.Mill, José G.Ribeiro, Antonio L. P.Thayer, Julian F.Bensenor, Isabela M.Lotufo, Paulo A.CAROTID INTIMA-MEDIA THICKNESSCOGNITIONEXECUTIVE FUNCTIONHEART RATE VARIABILITYHOMA-IRHOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCEHRVIMTMEDIATION ANALYSESPATH MODELLINGTMTTRAIL MAKING TESThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.Fil: Kemp, Andrew H.. University of Sydney; Australia. Universidade de Sao Paulo; BrasilFil: Rodríguez López, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina. University of Sydney; Australia. Universidad Autónoma de Madrid; EspañaFil: Passos, Valeria M. A.. Universidade Federal de Minas Gerais; BrasilFil: Bittencourt, Marcio S.. Universidade de Sao Paulo; BrasilFil: Dantas, Eduardo M.. University of Vale do São Francisco; BrasilFil: Mill, José G.. Universidade Federal do Espírito Santo; BrasilFil: Ribeiro, Antonio L. P.. Universidade Federal de Minas Gerais; BrasilFil: Thayer, Julian F.. Ohio State University; Estados UnidosFil: Bensenor, Isabela M.. Universidade de Sao Paulo; BrasilFil: Lotufo, Paulo A.. Universidade de Sao Paulo; BrasilElsevier Science2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/85844Kemp, Andrew H.; Rodríguez López, Santiago; Passos, Valeria M. A.; Bittencourt, Marcio S.; Dantas, Eduardo M.; et al.; Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study; Elsevier Science; Biological Psychology; 117; 5-2016; 216-2240301-0511CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsycho.2016.04.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301051116300990?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:11:01Zoai:ri.conicet.gov.ar:11336/85844instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:11:01.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
title Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
spellingShingle Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
Kemp, Andrew H.
CAROTID INTIMA-MEDIA THICKNESS
COGNITION
EXECUTIVE FUNCTION
HEART RATE VARIABILITY
HOMA-IR
HOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCE
HRV
IMT
MEDIATION ANALYSES
PATH MODELLING
TMT
TRAIL MAKING TEST
title_short Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
title_full Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
title_fullStr Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
title_full_unstemmed Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
title_sort Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study
dc.creator.none.fl_str_mv Kemp, Andrew H.
Rodríguez López, Santiago
Passos, Valeria M. A.
Bittencourt, Marcio S.
Dantas, Eduardo M.
Mill, José G.
Ribeiro, Antonio L. P.
Thayer, Julian F.
Bensenor, Isabela M.
Lotufo, Paulo A.
author Kemp, Andrew H.
author_facet Kemp, Andrew H.
Rodríguez López, Santiago
Passos, Valeria M. A.
Bittencourt, Marcio S.
Dantas, Eduardo M.
Mill, José G.
Ribeiro, Antonio L. P.
Thayer, Julian F.
Bensenor, Isabela M.
Lotufo, Paulo A.
author_role author
author2 Rodríguez López, Santiago
Passos, Valeria M. A.
Bittencourt, Marcio S.
Dantas, Eduardo M.
Mill, José G.
Ribeiro, Antonio L. P.
Thayer, Julian F.
Bensenor, Isabela M.
Lotufo, Paulo A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CAROTID INTIMA-MEDIA THICKNESS
COGNITION
EXECUTIVE FUNCTION
HEART RATE VARIABILITY
HOMA-IR
HOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCE
HRV
IMT
MEDIATION ANALYSES
PATH MODELLING
TMT
TRAIL MAKING TEST
topic CAROTID INTIMA-MEDIA THICKNESS
COGNITION
EXECUTIVE FUNCTION
HEART RATE VARIABILITY
HOMA-IR
HOMEOSTASIS MODEL ASSESSMENT INDEX FOR INSULIN RESISTANCE
HRV
IMT
MEDIATION ANALYSES
PATH MODELLING
TMT
TRAIL MAKING TEST
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
Fil: Kemp, Andrew H.. University of Sydney; Australia. Universidade de Sao Paulo; Brasil
Fil: Rodríguez López, Santiago. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad. Universidad Nacional de Córdoba. Centro de Investigaciones y Estudios sobre Cultura y Sociedad; Argentina. University of Sydney; Australia. Universidad Autónoma de Madrid; España
Fil: Passos, Valeria M. A.. Universidade Federal de Minas Gerais; Brasil
Fil: Bittencourt, Marcio S.. Universidade de Sao Paulo; Brasil
Fil: Dantas, Eduardo M.. University of Vale do São Francisco; Brasil
Fil: Mill, José G.. Universidade Federal do Espírito Santo; Brasil
Fil: Ribeiro, Antonio L. P.. Universidade Federal de Minas Gerais; Brasil
Fil: Thayer, Julian F.. Ohio State University; Estados Unidos
Fil: Bensenor, Isabela M.. Universidade de Sao Paulo; Brasil
Fil: Lotufo, Paulo A.. Universidade de Sao Paulo; Brasil
description Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a 'spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment.
publishDate 2016
dc.date.none.fl_str_mv 2016-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/85844
Kemp, Andrew H.; Rodríguez López, Santiago; Passos, Valeria M. A.; Bittencourt, Marcio S.; Dantas, Eduardo M.; et al.; Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study; Elsevier Science; Biological Psychology; 117; 5-2016; 216-224
0301-0511
CONICET Digital
CONICET
url http://hdl.handle.net/11336/85844
identifier_str_mv Kemp, Andrew H.; Rodríguez López, Santiago; Passos, Valeria M. A.; Bittencourt, Marcio S.; Dantas, Eduardo M.; et al.; Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study; Elsevier Science; Biological Psychology; 117; 5-2016; 216-224
0301-0511
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.biopsycho.2016.04.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0301051116300990?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781480124022784
score 12.982451

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