Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness

Autores
Manterola, Hugo Luis; Lo Vercio, Lucas; Diaz, Alberto Alejandro; del Fresno, Mirta Mariana; Larrabide, Ignacio
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In low- and middle-income regions, a relatively large number of deaths occur from cardiovascular disease or stroke. Carotid intima–media thickness (cIMT) and carotid lumen diameter (cLD) are strong indicators of cardiovascular event risk and stenosis severity, respectively. The interactive open-source software described here, Cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis and treatment. Cimtool was validated using carotid phantoms and real images obtained using ultrasound. Expert users measured cIMT and cLD in regular practice and also with Cimtool. The results obtained with Cimtool were then compared with the results for the manual approach in terms of measurement agreement, time spent on the measurements and usability. Intra-observer variability when using Cimtool was also analyzed. Statistical analysis revealed strong agreement between the manual method and Cimtool (p > 0.01 for cIMT and cLD). The correlation coefficient for both cIMT and cLD measurements was r > 0.9. Moreover, this software allowed the users to spend considerably less time on each measurement (3.5 min per study versus 50 s with Cimtool on average). An open-source, interactive, validated tool for measuring cIMT and cLD clinically was thus developed. Compared with the manual approach, Cimtool's straightforward measurement flow allows the user to spend less time per measurement and has less standard deviation. The coefficients of variation for measurements and intra-observer variability were lower than those reported for recent automated approaches, even with low-quality images.
Fil: Manterola, Hugo Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina
Fil: Lo Vercio, Lucas. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina
Fil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: del Fresno, Mirta Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
Materia
ACTIVE CONTOURS
CAROTID
INTIMA–MEDIA THICKNESS
LUMEN DIAMETER
MEASUREMENT TOOL
ULTRASOUND
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/178108
Acceder
id CONICETDig_adebd2b794842996313cf94a5ae1e6c9
oai_identifier_str oai:ri.conicet.gov.ar:11336/178108
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media ThicknessManterola, Hugo LuisLo Vercio, LucasDiaz, Alberto Alejandrodel Fresno, Mirta MarianaLarrabide, IgnacioACTIVE CONTOURSCAROTIDINTIMA–MEDIA THICKNESSLUMEN DIAMETERMEASUREMENT TOOLULTRASOUNDhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1In low- and middle-income regions, a relatively large number of deaths occur from cardiovascular disease or stroke. Carotid intima–media thickness (cIMT) and carotid lumen diameter (cLD) are strong indicators of cardiovascular event risk and stenosis severity, respectively. The interactive open-source software described here, Cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis and treatment. Cimtool was validated using carotid phantoms and real images obtained using ultrasound. Expert users measured cIMT and cLD in regular practice and also with Cimtool. The results obtained with Cimtool were then compared with the results for the manual approach in terms of measurement agreement, time spent on the measurements and usability. Intra-observer variability when using Cimtool was also analyzed. Statistical analysis revealed strong agreement between the manual method and Cimtool (p > 0.01 for cIMT and cLD). The correlation coefficient for both cIMT and cLD measurements was r > 0.9. Moreover, this software allowed the users to spend considerably less time on each measurement (3.5 min per study versus 50 s with Cimtool on average). An open-source, interactive, validated tool for measuring cIMT and cLD clinically was thus developed. Compared with the manual approach, Cimtool's straightforward measurement flow allows the user to spend less time per measurement and has less standard deviation. The coefficients of variation for measurements and intra-observer variability were lower than those reported for recent automated approaches, even with low-quality images.Fil: Manterola, Hugo Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; ArgentinaFil: Lo Vercio, Lucas. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; ArgentinaFil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: del Fresno, Mirta Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaElsevier Science Inc.2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/178108Manterola, Hugo Luis; Lo Vercio, Lucas; Diaz, Alberto Alejandro; del Fresno, Mirta Mariana; Larrabide, Ignacio; Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness; Elsevier Science Inc.; Ultrasound In Medicine And Biology; 44; 8; 8-2018; 1873-18810301-5629CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.ultrasmedbio.2018.04.001info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:27Zoai:ri.conicet.gov.ar:11336/178108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:27.645CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
title Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
spellingShingle Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
Manterola, Hugo Luis
ACTIVE CONTOURS
CAROTID
INTIMA–MEDIA THICKNESS
LUMEN DIAMETER
MEASUREMENT TOOL
ULTRASOUND
title_short Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
title_full Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
title_fullStr Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
title_full_unstemmed Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
title_sort Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness
dc.creator.none.fl_str_mv Manterola, Hugo Luis
Lo Vercio, Lucas
Diaz, Alberto Alejandro
del Fresno, Mirta Mariana
Larrabide, Ignacio
author Manterola, Hugo Luis
author_facet Manterola, Hugo Luis
Lo Vercio, Lucas
Diaz, Alberto Alejandro
del Fresno, Mirta Mariana
Larrabide, Ignacio
author_role author
author2 Lo Vercio, Lucas
Diaz, Alberto Alejandro
del Fresno, Mirta Mariana
Larrabide, Ignacio
author2_role author
author
author
author
dc.subject.none.fl_str_mv ACTIVE CONTOURS
CAROTID
INTIMA–MEDIA THICKNESS
LUMEN DIAMETER
MEASUREMENT TOOL
ULTRASOUND
topic ACTIVE CONTOURS
CAROTID
INTIMA–MEDIA THICKNESS
LUMEN DIAMETER
MEASUREMENT TOOL
ULTRASOUND
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In low- and middle-income regions, a relatively large number of deaths occur from cardiovascular disease or stroke. Carotid intima–media thickness (cIMT) and carotid lumen diameter (cLD) are strong indicators of cardiovascular event risk and stenosis severity, respectively. The interactive open-source software described here, Cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis and treatment. Cimtool was validated using carotid phantoms and real images obtained using ultrasound. Expert users measured cIMT and cLD in regular practice and also with Cimtool. The results obtained with Cimtool were then compared with the results for the manual approach in terms of measurement agreement, time spent on the measurements and usability. Intra-observer variability when using Cimtool was also analyzed. Statistical analysis revealed strong agreement between the manual method and Cimtool (p > 0.01 for cIMT and cLD). The correlation coefficient for both cIMT and cLD measurements was r > 0.9. Moreover, this software allowed the users to spend considerably less time on each measurement (3.5 min per study versus 50 s with Cimtool on average). An open-source, interactive, validated tool for measuring cIMT and cLD clinically was thus developed. Compared with the manual approach, Cimtool's straightforward measurement flow allows the user to spend less time per measurement and has less standard deviation. The coefficients of variation for measurements and intra-observer variability were lower than those reported for recent automated approaches, even with low-quality images.
Fil: Manterola, Hugo Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina
Fil: Lo Vercio, Lucas. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina
Fil: Diaz, Alberto Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: del Fresno, Mirta Mariana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
description In low- and middle-income regions, a relatively large number of deaths occur from cardiovascular disease or stroke. Carotid intima–media thickness (cIMT) and carotid lumen diameter (cLD) are strong indicators of cardiovascular event risk and stenosis severity, respectively. The interactive open-source software described here, Cimtool, is based on active contours for measuring these indicators in clinical practice and thus helping in preventive diagnosis and treatment. Cimtool was validated using carotid phantoms and real images obtained using ultrasound. Expert users measured cIMT and cLD in regular practice and also with Cimtool. The results obtained with Cimtool were then compared with the results for the manual approach in terms of measurement agreement, time spent on the measurements and usability. Intra-observer variability when using Cimtool was also analyzed. Statistical analysis revealed strong agreement between the manual method and Cimtool (p > 0.01 for cIMT and cLD). The correlation coefficient for both cIMT and cLD measurements was r > 0.9. Moreover, this software allowed the users to spend considerably less time on each measurement (3.5 min per study versus 50 s with Cimtool on average). An open-source, interactive, validated tool for measuring cIMT and cLD clinically was thus developed. Compared with the manual approach, Cimtool's straightforward measurement flow allows the user to spend less time per measurement and has less standard deviation. The coefficients of variation for measurements and intra-observer variability were lower than those reported for recent automated approaches, even with low-quality images.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/178108
Manterola, Hugo Luis; Lo Vercio, Lucas; Diaz, Alberto Alejandro; del Fresno, Mirta Mariana; Larrabide, Ignacio; Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness; Elsevier Science Inc.; Ultrasound In Medicine And Biology; 44; 8; 8-2018; 1873-1881
0301-5629
CONICET Digital
CONICET
url http://hdl.handle.net/11336/178108
identifier_str_mv Manterola, Hugo Luis; Lo Vercio, Lucas; Diaz, Alberto Alejandro; del Fresno, Mirta Mariana; Larrabide, Ignacio; Validation of an Open-Source Tool for Measuring Carotid Lumen Diameter and Intima–Media Thickness; Elsevier Science Inc.; Ultrasound In Medicine And Biology; 44; 8; 8-2018; 1873-1881
0301-5629
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ultrasmedbio.2018.04.001
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613531092123648
score 13.070432

Publicaciones similares