Non-alcoholic fatty liver disease is strongly associated with carotid atherosclerosis: A systematic review

• Autores: Sookoian, Silvia Cristina; Pirola, Carlos José
• Año de publicación: 2008
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: NAFLD; INTIMA CAROTID THICKNESS; ATHEROSCLEROSIS; PLAQUES
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background/Aims:To perform a systematic review of the studies addressing the association between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (IMT)./Aims:To perform a systematic review of the studies addressing the association between non-alcoholic fatty liver disease (NAFLD) and carotid intima-media thickness (IMT). Methods: Literature searches identified seven studies that met inclusion criteria: population-based or hospital-based case-control studies about the relation between NAFLD and carotid IMT, in which information on number of subjects in controls and NAFLD patients, and data to evaluate carotid IMT and carotid plaques (measured by carotid ultrasound) could be extracted. Results:From a total of 3497 subjects (1427 patients and 2070 controls), we found a significant association between NAFLD and carotid IMT either in fixed (D: 0.51, 95% CI: 0.44?0.58, p < 1 108) or random models (D: 1.44, CI: 95% 0.63?2.24, p < 0.0006). Meta-regression analysis showed that mean differences in alanine aminotransferase and c-GT were strongly correlated with those in IMT (p < 0.00006 and 0.004, respectively). In addition, 5 reports including 3212 subjects showed that carotid plaques were more frequently observed in NAFLD patients in comparison with controls, fixed model (p < 1 1010), OR: 1.97 95% CI: 1.67?2.32 and random model p < 0.0002, OR: 3.13, 95% CI: 1.75?5.58.:From a total of 3497 subjects (1427 patients and 2070 controls), we found a significant association between NAFLD and carotid IMT either in fixed (D: 0.51, 95% CI: 0.44?0.58, p < 1 108) or random models (D: 1.44, CI: 95% 0.63?2.24, p < 0.0006). Meta-regression analysis showed that mean differences in alanine aminotransferase and c-GT were strongly correlated with those in IMT (p < 0.00006 and 0.004, respectively). In addition, 5 reports including 3212 subjects showed that carotid plaques were more frequently observed in NAFLD patients in comparison with controls, fixed model (p < 1 1010), OR: 1.97 95% CI: 1.67?2.32 and random model p < 0.0002, OR: 3.13, 95% CI: 1.75?5.58. Conclusions: Routine measurement of carotid IMT might be implemented in NAFLD patients, as they carry an increase of 13% of carotid IMT. : Routine measurement of carotid IMT might be implemented in NAFLD patients, as they carry an increase of 13% of carotid IMT.
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina