Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment
- Autores
- Cantón, Lucila; Cantón, Candela; Dominguez, Maria Paula; Farias, Cristina Elena; Valente, Marcela; Alvarez, Luis Ignacio; Lanusse, Carlos Edmundo; Signorini, Marcelo; Moreno Torrejon, Laura
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Introduction: Argentina is traditionally a beef producer country. However, in recent years pork and chicken production have widely grown. These productions are closely linked to veterinary drug use for bacterial control. Accordingly, if good veterinary practices are not followed, food of animal origin could contain drug residues above the Maximum Residue Limit (MRL). Antibacterial drug residues in animal tissues may induce toxic or allergic reactions and promote antimicrobial resistance with a serious impact on human health. Residue monitoring programs consist of foodstuff sampling to determine potential drug residues. This study aimed to monitor, asses the exposure, and characterize the potential risk of antibacterial residues in animal products for local consumption in Buenos Aires province (Argentina). Materials and Methods: Antibacterial residues of enrofloxacin (EFX), amoxicillin (AMX), oxytetracycline (OTC), tilmicosin (TIL), and monensin (MON) were monitored in edible tissues from bovine, pork, and chicken species. Based on the Argentinian food culture, the following edible tissues were purchased from supermarkets, butchers, poultry shops, and retail stores in the cities involved in the trial: 360 meat (150 beef, 111 pork, and 89 chicken), 360 fat (150 beef fat, 111 pork fat, and 89 chicken fat), 91 beef liver, 78 beef kidney, and 33 sweetbreads samples. Tissue samples were analyzed by HPLC-fluorescence or UFLC-MS/MS. Considering that the tissues are not consumed raw, based on previously reported data, antibacterial residue stability during conventional cooking methods was contemplated for the analysis. Finally, factors such as antibacterial residue prevalence; residue concentrations; residue stability after different cooking methods; and bovine, pork, and chicken tissue consumption, were modeled by the @Risk software to predict the probability of consuming tissues with residues above the Admitted Daily Intake. Results and Conclusions: EFX, OTC, AMX, TIL, and MON antibacterial residues were found in bovine, pork, and chicken tissues. 9.4% of collected tissue samples had quantifiable drug residue levels and 2.7% had residue concentrations exceeding the MRL out of 922 targeted samples. Taking into account the levels of quantified antibacterial residues, the exposure to them, and the characterization of the risk by the described methodology, it was concluded that these antibacterial residues do not constitute a direct risk to consumers' health. However, the high frequency of antibacterial drug residues at detectable levels found in food should not be ignored, due to their possible contribution to the development of bacterial resistance when ingested and therefore with indirect consequences on health.
Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
15th International Congress of The European Association for Veterinary Pharmacology & Toxicology
Brujas
Bélgica
European Association for Veterinary Pharmacology & Toxicology - Materia
-
ANTIBACTERIALS
DRUG RESIDUES
EXPOSURE ASSESSMENT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/218273
Ver los metadatos del registro completo
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Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessmentCantón, LucilaCantón, CandelaDominguez, Maria PaulaFarias, Cristina ElenaValente, MarcelaAlvarez, Luis IgnacioLanusse, Carlos EdmundoSignorini, MarceloMoreno Torrejon, LauraANTIBACTERIALSDRUG RESIDUESEXPOSURE ASSESSMENThttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Introduction: Argentina is traditionally a beef producer country. However, in recent years pork and chicken production have widely grown. These productions are closely linked to veterinary drug use for bacterial control. Accordingly, if good veterinary practices are not followed, food of animal origin could contain drug residues above the Maximum Residue Limit (MRL). Antibacterial drug residues in animal tissues may induce toxic or allergic reactions and promote antimicrobial resistance with a serious impact on human health. Residue monitoring programs consist of foodstuff sampling to determine potential drug residues. This study aimed to monitor, asses the exposure, and characterize the potential risk of antibacterial residues in animal products for local consumption in Buenos Aires province (Argentina). Materials and Methods: Antibacterial residues of enrofloxacin (EFX), amoxicillin (AMX), oxytetracycline (OTC), tilmicosin (TIL), and monensin (MON) were monitored in edible tissues from bovine, pork, and chicken species. Based on the Argentinian food culture, the following edible tissues were purchased from supermarkets, butchers, poultry shops, and retail stores in the cities involved in the trial: 360 meat (150 beef, 111 pork, and 89 chicken), 360 fat (150 beef fat, 111 pork fat, and 89 chicken fat), 91 beef liver, 78 beef kidney, and 33 sweetbreads samples. Tissue samples were analyzed by HPLC-fluorescence or UFLC-MS/MS. Considering that the tissues are not consumed raw, based on previously reported data, antibacterial residue stability during conventional cooking methods was contemplated for the analysis. Finally, factors such as antibacterial residue prevalence; residue concentrations; residue stability after different cooking methods; and bovine, pork, and chicken tissue consumption, were modeled by the @Risk software to predict the probability of consuming tissues with residues above the Admitted Daily Intake. Results and Conclusions: EFX, OTC, AMX, TIL, and MON antibacterial residues were found in bovine, pork, and chicken tissues. 9.4% of collected tissue samples had quantifiable drug residue levels and 2.7% had residue concentrations exceeding the MRL out of 922 targeted samples. Taking into account the levels of quantified antibacterial residues, the exposure to them, and the characterization of the risk by the described methodology, it was concluded that these antibacterial residues do not constitute a direct risk to consumers' health. However, the high frequency of antibacterial drug residues at detectable levels found in food should not be ignored, due to their possible contribution to the development of bacterial resistance when ingested and therefore with indirect consequences on health.Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina15th International Congress of The European Association for Veterinary Pharmacology & ToxicologyBrujasBélgicaEuropean Association for Veterinary Pharmacology & ToxicologyWiley2023info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectCongresoJournalhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/218273Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment; 15th International Congress of The European Association for Veterinary Pharmacology & Toxicology; Brujas; Bélgica; 2023; 127-1270140-77831365-2885CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/jvp.13366info:eu-repo/semantics/altIdentifier/doi/10.1111/jvp.13366info:eu-repo/semantics/altIdentifier/url/https://eavpt23.orgInternacionalinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:41:32Zoai:ri.conicet.gov.ar:11336/218273instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:41:33.347CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| title |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| spellingShingle |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment Cantón, Lucila ANTIBACTERIALS DRUG RESIDUES EXPOSURE ASSESSMENT |
| title_short |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| title_full |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| title_fullStr |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| title_full_unstemmed |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| title_sort |
Antibacterial drug residues in animal tissues for human consumption: monitoring and exposure assessment |
| dc.creator.none.fl_str_mv |
Cantón, Lucila Cantón, Candela Dominguez, Maria Paula Farias, Cristina Elena Valente, Marcela Alvarez, Luis Ignacio Lanusse, Carlos Edmundo Signorini, Marcelo Moreno Torrejon, Laura |
| author |
Cantón, Lucila |
| author_facet |
Cantón, Lucila Cantón, Candela Dominguez, Maria Paula Farias, Cristina Elena Valente, Marcela Alvarez, Luis Ignacio Lanusse, Carlos Edmundo Signorini, Marcelo Moreno Torrejon, Laura |
| author_role |
author |
| author2 |
Cantón, Candela Dominguez, Maria Paula Farias, Cristina Elena Valente, Marcela Alvarez, Luis Ignacio Lanusse, Carlos Edmundo Signorini, Marcelo Moreno Torrejon, Laura |
| author2_role |
author author author author author author author author |
| dc.subject.none.fl_str_mv |
ANTIBACTERIALS DRUG RESIDUES EXPOSURE ASSESSMENT |
| topic |
ANTIBACTERIALS DRUG RESIDUES EXPOSURE ASSESSMENT |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
| dc.description.none.fl_txt_mv |
Introduction: Argentina is traditionally a beef producer country. However, in recent years pork and chicken production have widely grown. These productions are closely linked to veterinary drug use for bacterial control. Accordingly, if good veterinary practices are not followed, food of animal origin could contain drug residues above the Maximum Residue Limit (MRL). Antibacterial drug residues in animal tissues may induce toxic or allergic reactions and promote antimicrobial resistance with a serious impact on human health. Residue monitoring programs consist of foodstuff sampling to determine potential drug residues. This study aimed to monitor, asses the exposure, and characterize the potential risk of antibacterial residues in animal products for local consumption in Buenos Aires province (Argentina). Materials and Methods: Antibacterial residues of enrofloxacin (EFX), amoxicillin (AMX), oxytetracycline (OTC), tilmicosin (TIL), and monensin (MON) were monitored in edible tissues from bovine, pork, and chicken species. Based on the Argentinian food culture, the following edible tissues were purchased from supermarkets, butchers, poultry shops, and retail stores in the cities involved in the trial: 360 meat (150 beef, 111 pork, and 89 chicken), 360 fat (150 beef fat, 111 pork fat, and 89 chicken fat), 91 beef liver, 78 beef kidney, and 33 sweetbreads samples. Tissue samples were analyzed by HPLC-fluorescence or UFLC-MS/MS. Considering that the tissues are not consumed raw, based on previously reported data, antibacterial residue stability during conventional cooking methods was contemplated for the analysis. Finally, factors such as antibacterial residue prevalence; residue concentrations; residue stability after different cooking methods; and bovine, pork, and chicken tissue consumption, were modeled by the @Risk software to predict the probability of consuming tissues with residues above the Admitted Daily Intake. Results and Conclusions: EFX, OTC, AMX, TIL, and MON antibacterial residues were found in bovine, pork, and chicken tissues. 9.4% of collected tissue samples had quantifiable drug residue levels and 2.7% had residue concentrations exceeding the MRL out of 922 targeted samples. Taking into account the levels of quantified antibacterial residues, the exposure to them, and the characterization of the risk by the described methodology, it was concluded that these antibacterial residues do not constitute a direct risk to consumers' health. However, the high frequency of antibacterial drug residues at detectable levels found in food should not be ignored, due to their possible contribution to the development of bacterial resistance when ingested and therefore with indirect consequences on health. Fil: Cantón, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Cantón, Candela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Dominguez, Maria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Farias, Cristina Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Valente, Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Alvarez, Luis Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Signorini, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Moreno Torrejon, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina 15th International Congress of The European Association for Veterinary Pharmacology & Toxicology Brujas Bélgica European Association for Veterinary Pharmacology & Toxicology |
| description |
Introduction: Argentina is traditionally a beef producer country. However, in recent years pork and chicken production have widely grown. These productions are closely linked to veterinary drug use for bacterial control. Accordingly, if good veterinary practices are not followed, food of animal origin could contain drug residues above the Maximum Residue Limit (MRL). Antibacterial drug residues in animal tissues may induce toxic or allergic reactions and promote antimicrobial resistance with a serious impact on human health. Residue monitoring programs consist of foodstuff sampling to determine potential drug residues. This study aimed to monitor, asses the exposure, and characterize the potential risk of antibacterial residues in animal products for local consumption in Buenos Aires province (Argentina). Materials and Methods: Antibacterial residues of enrofloxacin (EFX), amoxicillin (AMX), oxytetracycline (OTC), tilmicosin (TIL), and monensin (MON) were monitored in edible tissues from bovine, pork, and chicken species. Based on the Argentinian food culture, the following edible tissues were purchased from supermarkets, butchers, poultry shops, and retail stores in the cities involved in the trial: 360 meat (150 beef, 111 pork, and 89 chicken), 360 fat (150 beef fat, 111 pork fat, and 89 chicken fat), 91 beef liver, 78 beef kidney, and 33 sweetbreads samples. Tissue samples were analyzed by HPLC-fluorescence or UFLC-MS/MS. Considering that the tissues are not consumed raw, based on previously reported data, antibacterial residue stability during conventional cooking methods was contemplated for the analysis. Finally, factors such as antibacterial residue prevalence; residue concentrations; residue stability after different cooking methods; and bovine, pork, and chicken tissue consumption, were modeled by the @Risk software to predict the probability of consuming tissues with residues above the Admitted Daily Intake. Results and Conclusions: EFX, OTC, AMX, TIL, and MON antibacterial residues were found in bovine, pork, and chicken tissues. 9.4% of collected tissue samples had quantifiable drug residue levels and 2.7% had residue concentrations exceeding the MRL out of 922 targeted samples. Taking into account the levels of quantified antibacterial residues, the exposure to them, and the characterization of the risk by the described methodology, it was concluded that these antibacterial residues do not constitute a direct risk to consumers' health. However, the high frequency of antibacterial drug residues at detectable levels found in food should not be ignored, due to their possible contribution to the development of bacterial resistance when ingested and therefore with indirect consequences on health. |
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