Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1

Autores
Khaleque, M. A.; Bharti, A.; Gong, J.; Gray, P. J.; Sachdev, V.; Ciocca, Daniel Ramon; Stati, Arturo Oscar; Fanelli, Mariel Andrea; Calderwood, S. K.
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly induced by the transforming ligand heregulin and complexes incorporated a number of additional proteins including histone deacetylases (HDAC1 and 2) and Mi2α, all components of the NuRD corepressor complex. These complexes were induced to assemble on the chromatin of MCF7 breast carcinoma cells and associated with the promoters of estrogen-responsive genes. Such HSF1 complexes participate in repression of estrogen-dependent transcription in breast carcinoma cells treated with heregulin and this effect was inhibited by MTA1 knockdown. Repression of estrogen-dependent transcription may contribute to the role of HSF1 in cancer.
Fil: Khaleque, M. A.. Harvard Medical School; Estados Unidos. North South University; Bangladesh
Fil: Bharti, A.. Boston University; Estados Unidos
Fil: Gong, J.. Boston University; Estados Unidos
Fil: Gray, P. J.. Harvard Medical School; Estados Unidos
Fil: Sachdev, V.. Boston University; Estados Unidos
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Stati, Arturo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Calderwood, S. K.. Boston University; Estados Unidos. Harvard Medical School; Estados Unidos
Materia
Oncogenes
Breast Cancer
Heat Shock Proteins
Her-2/Neu
Metastasis
Associated Protein
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/80376
Acceder
id CONICETDig_9d4452d2782ab63af7cf01262e3ce957
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1Khaleque, M. A.Bharti, A.Gong, J.Gray, P. J.Sachdev, V.Ciocca, Daniel RamonStati, Arturo OscarFanelli, Mariel AndreaCalderwood, S. K.OncogenesBreast CancerHeat Shock ProteinsHer-2/NeuMetastasisAssociated Proteinhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly induced by the transforming ligand heregulin and complexes incorporated a number of additional proteins including histone deacetylases (HDAC1 and 2) and Mi2α, all components of the NuRD corepressor complex. These complexes were induced to assemble on the chromatin of MCF7 breast carcinoma cells and associated with the promoters of estrogen-responsive genes. Such HSF1 complexes participate in repression of estrogen-dependent transcription in breast carcinoma cells treated with heregulin and this effect was inhibited by MTA1 knockdown. Repression of estrogen-dependent transcription may contribute to the role of HSF1 in cancer.Fil: Khaleque, M. A.. Harvard Medical School; Estados Unidos. North South University; BangladeshFil: Bharti, A.. Boston University; Estados UnidosFil: Gong, J.. Boston University; Estados UnidosFil: Gray, P. J.. Harvard Medical School; Estados UnidosFil: Sachdev, V.. Boston University; Estados UnidosFil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Stati, Arturo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Calderwood, S. K.. Boston University; Estados Unidos. Harvard Medical School; Estados UnidosNature Publishing Group2008-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/80376Khaleque, M. A.; Bharti, A.; Gong, J.; Gray, P. J.; Sachdev, V.; et al.; Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1; Nature Publishing Group; Oncogene; 27; 13; 3-2008; 1886-18930950-9232CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/sj.onc.1210834info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/1210834info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:08:29Zoai:ri.conicet.gov.ar:11336/80376instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:08:30.073CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
title Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
spellingShingle Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
Khaleque, M. A.
Oncogenes
Breast Cancer
Heat Shock Proteins
Her-2/Neu
Metastasis
Associated Protein
title_short Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
title_full Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
title_fullStr Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
title_full_unstemmed Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
title_sort Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1
dc.creator.none.fl_str_mv Khaleque, M. A.
Bharti, A.
Gong, J.
Gray, P. J.
Sachdev, V.
Ciocca, Daniel Ramon
Stati, Arturo Oscar
Fanelli, Mariel Andrea
Calderwood, S. K.
author Khaleque, M. A.
author_facet Khaleque, M. A.
Bharti, A.
Gong, J.
Gray, P. J.
Sachdev, V.
Ciocca, Daniel Ramon
Stati, Arturo Oscar
Fanelli, Mariel Andrea
Calderwood, S. K.
author_role author
author2 Bharti, A.
Gong, J.
Gray, P. J.
Sachdev, V.
Ciocca, Daniel Ramon
Stati, Arturo Oscar
Fanelli, Mariel Andrea
Calderwood, S. K.
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Oncogenes
Breast Cancer
Heat Shock Proteins
Her-2/Neu
Metastasis
Associated Protein
topic Oncogenes
Breast Cancer
Heat Shock Proteins
Her-2/Neu
Metastasis
Associated Protein
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly induced by the transforming ligand heregulin and complexes incorporated a number of additional proteins including histone deacetylases (HDAC1 and 2) and Mi2α, all components of the NuRD corepressor complex. These complexes were induced to assemble on the chromatin of MCF7 breast carcinoma cells and associated with the promoters of estrogen-responsive genes. Such HSF1 complexes participate in repression of estrogen-dependent transcription in breast carcinoma cells treated with heregulin and this effect was inhibited by MTA1 knockdown. Repression of estrogen-dependent transcription may contribute to the role of HSF1 in cancer.
Fil: Khaleque, M. A.. Harvard Medical School; Estados Unidos. North South University; Bangladesh
Fil: Bharti, A.. Boston University; Estados Unidos
Fil: Gong, J.. Boston University; Estados Unidos
Fil: Gray, P. J.. Harvard Medical School; Estados Unidos
Fil: Sachdev, V.. Boston University; Estados Unidos
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Stati, Arturo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Fanelli, Mariel Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Calderwood, S. K.. Boston University; Estados Unidos. Harvard Medical School; Estados Unidos
description Heat shock factor 1 (HSF1), the transcriptional activator of the heat shock genes, is increasingly implicated in cancer. We have shown that HSF1 binds to the corepressor metastasis-associated protein 1 (MTA1) in vitro and in human breast carcinoma samples. HSF1-MTA1 complex formation was strongly induced by the transforming ligand heregulin and complexes incorporated a number of additional proteins including histone deacetylases (HDAC1 and 2) and Mi2α, all components of the NuRD corepressor complex. These complexes were induced to assemble on the chromatin of MCF7 breast carcinoma cells and associated with the promoters of estrogen-responsive genes. Such HSF1 complexes participate in repression of estrogen-dependent transcription in breast carcinoma cells treated with heregulin and this effect was inhibited by MTA1 knockdown. Repression of estrogen-dependent transcription may contribute to the role of HSF1 in cancer.
publishDate 2008
dc.date.none.fl_str_mv 2008-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/80376
Khaleque, M. A.; Bharti, A.; Gong, J.; Gray, P. J.; Sachdev, V.; et al.; Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1; Nature Publishing Group; Oncogene; 27; 13; 3-2008; 1886-1893
0950-9232
CONICET Digital
CONICET
url http://hdl.handle.net/11336/80376
identifier_str_mv Khaleque, M. A.; Bharti, A.; Gong, J.; Gray, P. J.; Sachdev, V.; et al.; Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1; Nature Publishing Group; Oncogene; 27; 13; 3-2008; 1886-1893
0950-9232
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/sj.onc.1210834
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/1210834
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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