Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update

Autores
Ciocca, Daniel Ramon; Arrigo, Andre Patrick; Calderwood, Stuart K.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this
heat shock transcriptional regulon becomes co-opted by mechanisms that are currently unclear, although evidently triggered in the emerging tumor cell. Concerted activation of HSF1 and the accumulation of HSPs then participate in many of the traits that permit the malignant phenotype. Thus, cancers of many histologies exhibit activated HSF1 and increased HSP levels that may help to deter tumor suppression and evade therapy in the clinic. We review here the extensive work that has been carried out and is still in progress aimed at (1) understanding the oncogenic mechanisms by which HSP genes are switched on, (2) determining the roles of HSF1/HSP in malignant transformation and (3) discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer.
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Arrigo, Andre Patrick. Cancer Research Center of Lyon, Apoptosis Cancer and Development; Francia. Claude Bernard University; Francia
Fil: Calderwood, Stuart K.. Beth Israel Deaconess Medical Center. Department of Radiation Oncology; Estados Unidos
Materia
Proteinas
Golpe
Calor
Oncologia
Heat Shock Proteins
Heat Shock Factor
Cancer
Carcinogenesis
Drug Resistance
Apoptosis
Metastasis
Prognosis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/10080
Acceder
id CONICETDig_3f879eaac74b24d349d70faa7cf44022
oai_identifier_str oai:ri.conicet.gov.ar:11336/10080
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateCiocca, Daniel RamonArrigo, Andre PatrickCalderwood, Stuart K.ProteinasGolpeCalorOncologiaHeat Shock ProteinsHeat Shock FactorCancerCarcinogenesisDrug ResistanceApoptosisMetastasisPrognosishttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this<br />heat shock transcriptional regulon becomes co-opted by mechanisms that are currently unclear, although evidently triggered in the emerging tumor cell. Concerted activation of HSF1 and the accumulation of HSPs then participate in many of the traits that permit the malignant phenotype. Thus, cancers of many histologies exhibit activated HSF1 and increased HSP levels that may help to deter tumor suppression and evade therapy in the clinic. We review here the extensive work that has been carried out and is still in progress aimed at (1) understanding the oncogenic mechanisms by which HSP genes are switched on, (2) determining the roles of HSF1/HSP in malignant transformation and (3) discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer.Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Arrigo, Andre Patrick. Cancer Research Center of Lyon, Apoptosis Cancer and Development; Francia. Claude Bernard University; FranciaFil: Calderwood, Stuart K.. Beth Israel Deaconess Medical Center. Department of Radiation Oncology; Estados UnidosSpringer2013-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/10080Ciocca, Daniel Ramon; Arrigo, Andre Patrick; Calderwood, Stuart K.; Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update; Springer; Archives Of Toxicology; 87; 1; 1-2013; 19-480340-5761enginfo:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00204-012-0918-zinfo:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1007/s00204-012-0918-zinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905791/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:08Zoai:ri.conicet.gov.ar:11336/10080instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:09.149CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
title Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
spellingShingle Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
Ciocca, Daniel Ramon
Proteinas
Golpe
Calor
Oncologia
Heat Shock Proteins
Heat Shock Factor
Cancer
Carcinogenesis
Drug Resistance
Apoptosis
Metastasis
Prognosis
title_short Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
title_full Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
title_fullStr Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
title_full_unstemmed Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
title_sort Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
dc.creator.none.fl_str_mv Ciocca, Daniel Ramon
Arrigo, Andre Patrick
Calderwood, Stuart K.
author Ciocca, Daniel Ramon
author_facet Ciocca, Daniel Ramon
Arrigo, Andre Patrick
Calderwood, Stuart K.
author_role author
author2 Arrigo, Andre Patrick
Calderwood, Stuart K.
author2_role author
author
dc.subject.none.fl_str_mv Proteinas
Golpe
Calor
Oncologia
Heat Shock Proteins
Heat Shock Factor
Cancer
Carcinogenesis
Drug Resistance
Apoptosis
Metastasis
Prognosis
topic Proteinas
Golpe
Calor
Oncologia
Heat Shock Proteins
Heat Shock Factor
Cancer
Carcinogenesis
Drug Resistance
Apoptosis
Metastasis
Prognosis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this<br />heat shock transcriptional regulon becomes co-opted by mechanisms that are currently unclear, although evidently triggered in the emerging tumor cell. Concerted activation of HSF1 and the accumulation of HSPs then participate in many of the traits that permit the malignant phenotype. Thus, cancers of many histologies exhibit activated HSF1 and increased HSP levels that may help to deter tumor suppression and evade therapy in the clinic. We review here the extensive work that has been carried out and is still in progress aimed at (1) understanding the oncogenic mechanisms by which HSP genes are switched on, (2) determining the roles of HSF1/HSP in malignant transformation and (3) discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer.
Fil: Ciocca, Daniel Ramon. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Arrigo, Andre Patrick. Cancer Research Center of Lyon, Apoptosis Cancer and Development; Francia. Claude Bernard University; Francia
Fil: Calderwood, Stuart K.. Beth Israel Deaconess Medical Center. Department of Radiation Oncology; Estados Unidos
description Heat shock proteins (HSP) are a subset of the molecular chaperones, best known for their rapid and abundant induction by stress. HSP genes are activated at the transcriptional level by heat shock transcription factor 1 (HSF1). During the progression of many types of cancer, this<br />heat shock transcriptional regulon becomes co-opted by mechanisms that are currently unclear, although evidently triggered in the emerging tumor cell. Concerted activation of HSF1 and the accumulation of HSPs then participate in many of the traits that permit the malignant phenotype. Thus, cancers of many histologies exhibit activated HSF1 and increased HSP levels that may help to deter tumor suppression and evade therapy in the clinic. We review here the extensive work that has been carried out and is still in progress aimed at (1) understanding the oncogenic mechanisms by which HSP genes are switched on, (2) determining the roles of HSF1/HSP in malignant transformation and (3) discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer.
publishDate 2013
dc.date.none.fl_str_mv 2013-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/10080
Ciocca, Daniel Ramon; Arrigo, Andre Patrick; Calderwood, Stuart K.; Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update; Springer; Archives Of Toxicology; 87; 1; 1-2013; 19-48
0340-5761
url http://hdl.handle.net/11336/10080
identifier_str_mv Ciocca, Daniel Ramon; Arrigo, Andre Patrick; Calderwood, Stuart K.; Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update; Springer; Archives Of Toxicology; 87; 1; 1-2013; 19-48
0340-5761
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs00204-012-0918-z
info:eu-repo/semantics/altIdentifier/url/http://dx.doi.org/10.1007/s00204-012-0918-z
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905791/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844614490254999552
score 13.069144

Publicaciones similares