Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems

Autores
Navarro, Lucila; Minari, Roque Javier; Vaillard, Santiago Eduardo
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work weprepared a new family of photo-curable poly-(ethylene glycol)?fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate prepolymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems.Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
ELASTOMER
CONTROLLED RELEASE
PEG-FUMARATE
PHOTOPOLYMER
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/105513
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systemsNavarro, LucilaMinari, Roque JavierVaillard, Santiago EduardoELASTOMERCONTROLLED RELEASEPEG-FUMARATEPHOTOPOLYMERhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work weprepared a new family of photo-curable poly-(ethylene glycol)?fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate prepolymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems.Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaRoyal Society of Chemistry2019-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/105513Navarro, Lucila; Minari, Roque Javier; Vaillard, Santiago Eduardo; Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems; Royal Society of Chemistry; RSC Advances; 9; 1; 1-2019; 482-4902046-2069CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C8RA09336Ainfo:eu-repo/semantics/altIdentifier/doi/10.1039/c8ra09336ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:59Zoai:ri.conicet.gov.ar:11336/105513instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:59.892CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
title Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
spellingShingle Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
Navarro, Lucila
ELASTOMER
CONTROLLED RELEASE
PEG-FUMARATE
PHOTOPOLYMER
title_short Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
title_full Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
title_fullStr Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
title_full_unstemmed Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
title_sort Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
dc.creator.none.fl_str_mv Navarro, Lucila
Minari, Roque Javier
Vaillard, Santiago Eduardo
author Navarro, Lucila
author_facet Navarro, Lucila
Minari, Roque Javier
Vaillard, Santiago Eduardo
author_role author
author2 Minari, Roque Javier
Vaillard, Santiago Eduardo
author2_role author
author
dc.subject.none.fl_str_mv ELASTOMER
CONTROLLED RELEASE
PEG-FUMARATE
PHOTOPOLYMER
topic ELASTOMER
CONTROLLED RELEASE
PEG-FUMARATE
PHOTOPOLYMER
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work weprepared a new family of photo-curable poly-(ethylene glycol)?fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate prepolymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems.Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work weprepared a new family of photo-curable poly-(ethylene glycol)?fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate prepolymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems.Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.
publishDate 2019
dc.date.none.fl_str_mv 2019-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/105513
Navarro, Lucila; Minari, Roque Javier; Vaillard, Santiago Eduardo; Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems; Royal Society of Chemistry; RSC Advances; 9; 1; 1-2019; 482-490
2046-2069
CONICET Digital
CONICET
url http://hdl.handle.net/11336/105513
identifier_str_mv Navarro, Lucila; Minari, Roque Javier; Vaillard, Santiago Eduardo; Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems; Royal Society of Chemistry; RSC Advances; 9; 1; 1-2019; 482-490
2046-2069
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C8RA09336A
info:eu-repo/semantics/altIdentifier/doi/10.1039/c8ra09336a
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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