Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel

Autores
Navarro, Lucila; Minari, Roque Javier; Ceaglio, Natalia Analia; Masin, Marianela; Vaillard, Santiago Eduardo
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Over the past 10 years poly-(polyol alkanoate)s elastomers have intensively been investigated due to their extraordinary potential for soft tissue engineering applications. In this work, a family of novel hyperbranched elastomers based on pentaerythritol and adipic acid, modified with PEG of 200 and 400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoids the use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting the molar ratio of monomers and curing conditions. The elastomers, which are fully characterized by standard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell culture assays indicate that all materials are able to inhibit lung cancer cell proliferation and that the release of Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are good candidates for their use as eluting systems in long term cancer treatment.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ceaglio, Natalia Analia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; Argentina
Fil: Masin, Marianela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Materia
BRANCHED
CONTROLLED RELEASE
DRUG DELIVERY SYSTEMS
ELASTOMERS
FILMS
HYPERBRANCHED POLYMERS
POLYCONDENSATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/86596
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/86596
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of PaclitaxelNavarro, LucilaMinari, Roque JavierCeaglio, Natalia AnaliaMasin, MarianelaVaillard, Santiago EduardoBRANCHEDCONTROLLED RELEASEDRUG DELIVERY SYSTEMSELASTOMERSFILMSHYPERBRANCHED POLYMERSPOLYCONDENSATIONhttps://purl.org/becyt/ford/2.5https://purl.org/becyt/ford/2Over the past 10 years poly-(polyol alkanoate)s elastomers have intensively been investigated due to their extraordinary potential for soft tissue engineering applications. In this work, a family of novel hyperbranched elastomers based on pentaerythritol and adipic acid, modified with PEG of 200 and 400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoids the use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting the molar ratio of monomers and curing conditions. The elastomers, which are fully characterized by standard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell culture assays indicate that all materials are able to inhibit lung cancer cell proliferation and that the release of Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are good candidates for their use as eluting systems in long term cancer treatment.Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Ceaglio, Natalia Analia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; ArgentinaFil: Masin, Marianela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; ArgentinaFil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaJohn Wiley & Sons Inc2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/86596Navarro, Lucila; Minari, Roque Javier; Ceaglio, Natalia Analia; Masin, Marianela; Vaillard, Santiago Eduardo; Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel; John Wiley & Sons Inc; Journal of Polymer Science Part A: Polymer Chemistry; 56; 12; 6-2018; 1199-12090887-624XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/pola.28999info:eu-repo/semantics/altIdentifier/doi/10.1002/pola.28999info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:02:47Zoai:ri.conicet.gov.ar:11336/86596instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:02:47.886CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
title Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
spellingShingle Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
Navarro, Lucila
BRANCHED
CONTROLLED RELEASE
DRUG DELIVERY SYSTEMS
ELASTOMERS
FILMS
HYPERBRANCHED POLYMERS
POLYCONDENSATION
title_short Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
title_full Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
title_fullStr Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
title_full_unstemmed Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
title_sort Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel
dc.creator.none.fl_str_mv Navarro, Lucila
Minari, Roque Javier
Ceaglio, Natalia Analia
Masin, Marianela
Vaillard, Santiago Eduardo
author Navarro, Lucila
author_facet Navarro, Lucila
Minari, Roque Javier
Ceaglio, Natalia Analia
Masin, Marianela
Vaillard, Santiago Eduardo
author_role author
author2 Minari, Roque Javier
Ceaglio, Natalia Analia
Masin, Marianela
Vaillard, Santiago Eduardo
author2_role author
author
author
author
dc.subject.none.fl_str_mv BRANCHED
CONTROLLED RELEASE
DRUG DELIVERY SYSTEMS
ELASTOMERS
FILMS
HYPERBRANCHED POLYMERS
POLYCONDENSATION
topic BRANCHED
CONTROLLED RELEASE
DRUG DELIVERY SYSTEMS
ELASTOMERS
FILMS
HYPERBRANCHED POLYMERS
POLYCONDENSATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.5
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Over the past 10 years poly-(polyol alkanoate)s elastomers have intensively been investigated due to their extraordinary potential for soft tissue engineering applications. In this work, a family of novel hyperbranched elastomers based on pentaerythritol and adipic acid, modified with PEG of 200 and 400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoids the use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting the molar ratio of monomers and curing conditions. The elastomers, which are fully characterized by standard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell culture assays indicate that all materials are able to inhibit lung cancer cell proliferation and that the release of Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are good candidates for their use as eluting systems in long term cancer treatment.
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
Fil: Ceaglio, Natalia Analia. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; Argentina
Fil: Masin, Marianela. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas. Laboratorio de Cultivos Celulares; Argentina
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
description Over the past 10 years poly-(polyol alkanoate)s elastomers have intensively been investigated due to their extraordinary potential for soft tissue engineering applications. In this work, a family of novel hyperbranched elastomers based on pentaerythritol and adipic acid, modified with PEG of 200 and 400 Da, is synthesized. The polymers are obtained by a simple 2 steps thermal process that avoids the use of toxic catalysts. Noteworthy, elastomers properties can be finely tuned by adjusting the molar ratio of monomers and curing conditions. The elastomers, which are fully characterized by standard methods, show excellent results in the in vitro controlled release of Paclitaxel. Cell culture assays indicate that all materials are able to inhibit lung cancer cell proliferation and that the release of Paclitaxel reduce cancer cell viability, indicating that the elastomers prepared hereby are good candidates for their use as eluting systems in long term cancer treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/86596
Navarro, Lucila; Minari, Roque Javier; Ceaglio, Natalia Analia; Masin, Marianela; Vaillard, Santiago Eduardo; Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel; John Wiley & Sons Inc; Journal of Polymer Science Part A: Polymer Chemistry; 56; 12; 6-2018; 1199-1209
0887-624X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/86596
identifier_str_mv Navarro, Lucila; Minari, Roque Javier; Ceaglio, Natalia Analia; Masin, Marianela; Vaillard, Santiago Eduardo; Poly-(pentaerythritol adipate)-co-(poly ethylene glycol) Elastomers for the Sustained Release of Paclitaxel; John Wiley & Sons Inc; Journal of Polymer Science Part A: Polymer Chemistry; 56; 12; 6-2018; 1199-1209
0887-624X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://doi.wiley.com/10.1002/pola.28999
info:eu-repo/semantics/altIdentifier/doi/10.1002/pola.28999
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Inc
publisher.none.fl_str_mv John Wiley & Sons Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842980039764738048
score 13.004268

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