Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films

Autores
de Queiroz, Alvaro A.A.; Abraham, Gustavo Abel; Higa, Olga Zazuco
Año de publicación
2006
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The effect of γ-radiation doses of 12.5–380 kGy on the infrared spectra, gel content, mechanical properties, and the release of oxobutyl-5-fluoro-2′-deoxyuridine (OfdUrd, an antitumor agent) from poly(ethylene-co-vinyl acetate) (EVA) films was studied. The results showed that the application of radiation doses produced a crosslinking reaction leading to a maximum gel content of about 85% in the case of 150 kGy. Higher doses did not increase the gel content in EVA films. The mechanical properties (tensile strength, percentage elongation at break and Young’s modulus) of all studied EVA matrices were affected by the exposure to γ-radiation. Irradiation doses over 50 kGy caused an increase in the Young’s modulus of EVA and at the same time a decrease in the strain per cent. Moreover, the network structure formed after irradiation reduced significantly the OFdUrd release from EVA films. In this manner, the radiation dose applied to the polymeric matrix modulated the release of OFdUrd, avoiding the high concentrations that may cause severe systemic toxicity. The loading of OFdUrd to EVA film triggered a slight hyperemia after implantation, while the inflammatory reaction was only observed during the first two days.
Fil: de Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
Materia
Controlled Release
Cancer Treatment
5-Fluorouridine
Radiation-Crosslinking
Crosslinked Eva
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41682
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) filmsde Queiroz, Alvaro A.A.Abraham, Gustavo AbelHiga, Olga ZazucoControlled ReleaseCancer Treatment5-FluorouridineRadiation-CrosslinkingCrosslinked Evahttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3https://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The effect of γ-radiation doses of 12.5–380 kGy on the infrared spectra, gel content, mechanical properties, and the release of oxobutyl-5-fluoro-2′-deoxyuridine (OfdUrd, an antitumor agent) from poly(ethylene-co-vinyl acetate) (EVA) films was studied. The results showed that the application of radiation doses produced a crosslinking reaction leading to a maximum gel content of about 85% in the case of 150 kGy. Higher doses did not increase the gel content in EVA films. The mechanical properties (tensile strength, percentage elongation at break and Young’s modulus) of all studied EVA matrices were affected by the exposure to γ-radiation. Irradiation doses over 50 kGy caused an increase in the Young’s modulus of EVA and at the same time a decrease in the strain per cent. Moreover, the network structure formed after irradiation reduced significantly the OFdUrd release from EVA films. In this manner, the radiation dose applied to the polymeric matrix modulated the release of OFdUrd, avoiding the high concentrations that may cause severe systemic toxicity. The loading of OFdUrd to EVA film triggered a slight hyperemia after implantation, while the inflammatory reaction was only observed during the first two days.Fil: de Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; BrasilFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; BrasilElsevier2006-11-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41682de Queiroz, Alvaro A.A.; Abraham, Gustavo Abel; Higa, Olga Zazuco; Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films; Elsevier; Acta Biomaterialia; 2; 6; 28-11-2006; 641-6501742-7061CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1742706106000651info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2006.05.010info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:36:45Zoai:ri.conicet.gov.ar:11336/41682instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:36:46.001CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
title Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
spellingShingle Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
de Queiroz, Alvaro A.A.
Controlled Release
Cancer Treatment
5-Fluorouridine
Radiation-Crosslinking
Crosslinked Eva
title_short Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
title_full Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
title_fullStr Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
title_full_unstemmed Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
title_sort Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films
dc.creator.none.fl_str_mv de Queiroz, Alvaro A.A.
Abraham, Gustavo Abel
Higa, Olga Zazuco
author de Queiroz, Alvaro A.A.
author_facet de Queiroz, Alvaro A.A.
Abraham, Gustavo Abel
Higa, Olga Zazuco
author_role author
author2 Abraham, Gustavo Abel
Higa, Olga Zazuco
author2_role author
author
dc.subject.none.fl_str_mv Controlled Release
Cancer Treatment
5-Fluorouridine
Radiation-Crosslinking
Crosslinked Eva
topic Controlled Release
Cancer Treatment
5-Fluorouridine
Radiation-Crosslinking
Crosslinked Eva
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The effect of γ-radiation doses of 12.5–380 kGy on the infrared spectra, gel content, mechanical properties, and the release of oxobutyl-5-fluoro-2′-deoxyuridine (OfdUrd, an antitumor agent) from poly(ethylene-co-vinyl acetate) (EVA) films was studied. The results showed that the application of radiation doses produced a crosslinking reaction leading to a maximum gel content of about 85% in the case of 150 kGy. Higher doses did not increase the gel content in EVA films. The mechanical properties (tensile strength, percentage elongation at break and Young’s modulus) of all studied EVA matrices were affected by the exposure to γ-radiation. Irradiation doses over 50 kGy caused an increase in the Young’s modulus of EVA and at the same time a decrease in the strain per cent. Moreover, the network structure formed after irradiation reduced significantly the OFdUrd release from EVA films. In this manner, the radiation dose applied to the polymeric matrix modulated the release of OFdUrd, avoiding the high concentrations that may cause severe systemic toxicity. The loading of OFdUrd to EVA film triggered a slight hyperemia after implantation, while the inflammatory reaction was only observed during the first two days.
Fil: de Queiroz, Alvaro A.A.. Universidade Federal de Itajubá; Brasil
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Higa, Olga Zazuco. Comissao Nacional de Energia Nuclear. Centro de Lasers e Aplicacoes. Instituto de Pesquisas Energeticas e Nucleares.; Brasil
description The effect of γ-radiation doses of 12.5–380 kGy on the infrared spectra, gel content, mechanical properties, and the release of oxobutyl-5-fluoro-2′-deoxyuridine (OfdUrd, an antitumor agent) from poly(ethylene-co-vinyl acetate) (EVA) films was studied. The results showed that the application of radiation doses produced a crosslinking reaction leading to a maximum gel content of about 85% in the case of 150 kGy. Higher doses did not increase the gel content in EVA films. The mechanical properties (tensile strength, percentage elongation at break and Young’s modulus) of all studied EVA matrices were affected by the exposure to γ-radiation. Irradiation doses over 50 kGy caused an increase in the Young’s modulus of EVA and at the same time a decrease in the strain per cent. Moreover, the network structure formed after irradiation reduced significantly the OFdUrd release from EVA films. In this manner, the radiation dose applied to the polymeric matrix modulated the release of OFdUrd, avoiding the high concentrations that may cause severe systemic toxicity. The loading of OFdUrd to EVA film triggered a slight hyperemia after implantation, while the inflammatory reaction was only observed during the first two days.
publishDate 2006
dc.date.none.fl_str_mv 2006-11-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41682
de Queiroz, Alvaro A.A.; Abraham, Gustavo Abel; Higa, Olga Zazuco; Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films; Elsevier; Acta Biomaterialia; 2; 6; 28-11-2006; 641-650
1742-7061
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41682
identifier_str_mv de Queiroz, Alvaro A.A.; Abraham, Gustavo Abel; Higa, Olga Zazuco; Controlled release of 5-fluorouridine from radiation-crosslinked poly(ethylene-co-vinyl acetate) films; Elsevier; Acta Biomaterialia; 2; 6; 28-11-2006; 641-650
1742-7061
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1742706106000651
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.actbio.2006.05.010
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846082835465633792
score 13.22299

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