Socialization causes long-lasting behavioral changes

Autores
Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; Turiégano, Enrique; Beckwith, Esteban Javier; Martin, Francisco A.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In modern human societies, social isolation acts as a negative factor for health and life quality.On the other hand, social interaction also has profound effects on animal and human, impactingaggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the flyDrosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España
Fil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; España
Fil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; España
Fil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; España
Fil: Turiégano, Enrique. Universidad Autónoma de Madrid; España
Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; España
Materia
SOCIALIZATION
SLEEP
AGGRESSION
FEEDING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/267473
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Socialization causes long-lasting behavioral changesGil Martí, BeatrizIsidro Mézcua, JuliaPoza Rodriguez, AdrianaAsti Tello, Gerson SmithTreves, GaiaTuriégano, EnriqueBeckwith, Esteban JavierMartin, Francisco A.SOCIALIZATIONSLEEPAGGRESSIONFEEDINGhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In modern human societies, social isolation acts as a negative factor for health and life quality.On the other hand, social interaction also has profound effects on animal and human, impactingaggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the flyDrosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; EspañaFil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; EspañaFil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; EspañaFil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; EspañaFil: Turiégano, Enrique. Universidad Autónoma de Madrid; EspañaFil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; EspañaNature Publishing Group2024-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/267473Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Nature Publishing Group; Scientific Reports; 14; 1; 9-2024; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-024-73218-winfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-73218-winfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:00:45Zoai:ri.conicet.gov.ar:11336/267473instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:00:45.715CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Socialization causes long-lasting behavioral changes
title Socialization causes long-lasting behavioral changes
spellingShingle Socialization causes long-lasting behavioral changes
Gil Martí, Beatriz
SOCIALIZATION
SLEEP
AGGRESSION
FEEDING
title_short Socialization causes long-lasting behavioral changes
title_full Socialization causes long-lasting behavioral changes
title_fullStr Socialization causes long-lasting behavioral changes
title_full_unstemmed Socialization causes long-lasting behavioral changes
title_sort Socialization causes long-lasting behavioral changes
dc.creator.none.fl_str_mv Gil Martí, Beatriz
Isidro Mézcua, Julia
Poza Rodriguez, Adriana
Asti Tello, Gerson Smith
Treves, Gaia
Turiégano, Enrique
Beckwith, Esteban Javier
Martin, Francisco A.
author Gil Martí, Beatriz
author_facet Gil Martí, Beatriz
Isidro Mézcua, Julia
Poza Rodriguez, Adriana
Asti Tello, Gerson Smith
Treves, Gaia
Turiégano, Enrique
Beckwith, Esteban Javier
Martin, Francisco A.
author_role author
author2 Isidro Mézcua, Julia
Poza Rodriguez, Adriana
Asti Tello, Gerson Smith
Treves, Gaia
Turiégano, Enrique
Beckwith, Esteban Javier
Martin, Francisco A.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SOCIALIZATION
SLEEP
AGGRESSION
FEEDING
topic SOCIALIZATION
SLEEP
AGGRESSION
FEEDING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In modern human societies, social isolation acts as a negative factor for health and life quality.On the other hand, social interaction also has profound effects on animal and human, impactingaggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the flyDrosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España
Fil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; España
Fil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; España
Fil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; España
Fil: Turiégano, Enrique. Universidad Autónoma de Madrid; España
Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; España
description In modern human societies, social isolation acts as a negative factor for health and life quality.On the other hand, social interaction also has profound effects on animal and human, impactingaggressiveness, feeding and sleep, among many other behaviors. Here, we observe that in the flyDrosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. These modified behaviors maintain similar levels for 24 h and persist up to 72 h, although showing a progressive decay. We also find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
publishDate 2024
dc.date.none.fl_str_mv 2024-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/267473
Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Nature Publishing Group; Scientific Reports; 14; 1; 9-2024; 1-10
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/267473
identifier_str_mv Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Nature Publishing Group; Scientific Reports; 14; 1; 9-2024; 1-10
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-024-73218-w
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-024-73218-w
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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