Neurophysiological and behavioral synchronization in group-living and sleeping mice

Autores
Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; Rothschild, Gideon; Eban Rothschild, Ada
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.
Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados Unidos
Fil: Markunas, Chelsea. University of Michigan; Estados Unidos
Fil: Kudlak, Tyler. University of Michigan; Estados Unidos
Fil: Kohtz, Chani. University of Michigan; Estados Unidos
Fil: Vyssotski, Alexei L.. Universitat Zurich; Suiza
Fil: Rothschild, Gideon. University of Michigan; Estados Unidos
Fil: Eban Rothschild, Ada. University of Michigan; Estados Unidos
Materia
SOCIAL CONTACT
NREM SLEEP
REM SLEEP
HUDDLING BEHAVIOR
WIRELESS TECHNOLOGY
NEUROPHYSIOLOGICAL SYNCHRONIZATION
SOMATOLONGING
IMMERSIVE SOCIAL INTERACTIONS ASSAY
PRE-SLEEP BEHAVIOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/254934

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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Neurophysiological and behavioral synchronization in group-living and sleeping miceSotelo, María InésMarkunas, ChelseaKudlak, TylerKohtz, ChaniVyssotski, Alexei L.Rothschild, GideonEban Rothschild, AdaSOCIAL CONTACTNREM SLEEPREM SLEEPHUDDLING BEHAVIORWIRELESS TECHNOLOGYNEUROPHYSIOLOGICAL SYNCHRONIZATIONSOMATOLONGINGIMMERSIVE SOCIAL INTERACTIONS ASSAYPRE-SLEEP BEHAVIORhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados UnidosFil: Markunas, Chelsea. University of Michigan; Estados UnidosFil: Kudlak, Tyler. University of Michigan; Estados UnidosFil: Kohtz, Chani. University of Michigan; Estados UnidosFil: Vyssotski, Alexei L.. Universitat Zurich; SuizaFil: Rothschild, Gideon. University of Michigan; Estados UnidosFil: Eban Rothschild, Ada. University of Michigan; Estados UnidosCell Press2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/254934Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-1460960-9822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982223016524info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2023.11.065info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:25:52Zoai:ri.conicet.gov.ar:11336/254934instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:25:53.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Neurophysiological and behavioral synchronization in group-living and sleeping mice
title Neurophysiological and behavioral synchronization in group-living and sleeping mice
spellingShingle Neurophysiological and behavioral synchronization in group-living and sleeping mice
Sotelo, María Inés
SOCIAL CONTACT
NREM SLEEP
REM SLEEP
HUDDLING BEHAVIOR
WIRELESS TECHNOLOGY
NEUROPHYSIOLOGICAL SYNCHRONIZATION
SOMATOLONGING
IMMERSIVE SOCIAL INTERACTIONS ASSAY
PRE-SLEEP BEHAVIOR
title_short Neurophysiological and behavioral synchronization in group-living and sleeping mice
title_full Neurophysiological and behavioral synchronization in group-living and sleeping mice
title_fullStr Neurophysiological and behavioral synchronization in group-living and sleeping mice
title_full_unstemmed Neurophysiological and behavioral synchronization in group-living and sleeping mice
title_sort Neurophysiological and behavioral synchronization in group-living and sleeping mice
dc.creator.none.fl_str_mv Sotelo, María Inés
Markunas, Chelsea
Kudlak, Tyler
Kohtz, Chani
Vyssotski, Alexei L.
Rothschild, Gideon
Eban Rothschild, Ada
author Sotelo, María Inés
author_facet Sotelo, María Inés
Markunas, Chelsea
Kudlak, Tyler
Kohtz, Chani
Vyssotski, Alexei L.
Rothschild, Gideon
Eban Rothschild, Ada
author_role author
author2 Markunas, Chelsea
Kudlak, Tyler
Kohtz, Chani
Vyssotski, Alexei L.
Rothschild, Gideon
Eban Rothschild, Ada
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv SOCIAL CONTACT
NREM SLEEP
REM SLEEP
HUDDLING BEHAVIOR
WIRELESS TECHNOLOGY
NEUROPHYSIOLOGICAL SYNCHRONIZATION
SOMATOLONGING
IMMERSIVE SOCIAL INTERACTIONS ASSAY
PRE-SLEEP BEHAVIOR
topic SOCIAL CONTACT
NREM SLEEP
REM SLEEP
HUDDLING BEHAVIOR
WIRELESS TECHNOLOGY
NEUROPHYSIOLOGICAL SYNCHRONIZATION
SOMATOLONGING
IMMERSIVE SOCIAL INTERACTIONS ASSAY
PRE-SLEEP BEHAVIOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.
Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados Unidos
Fil: Markunas, Chelsea. University of Michigan; Estados Unidos
Fil: Kudlak, Tyler. University of Michigan; Estados Unidos
Fil: Kohtz, Chani. University of Michigan; Estados Unidos
Fil: Vyssotski, Alexei L.. Universitat Zurich; Suiza
Fil: Rothschild, Gideon. University of Michigan; Estados Unidos
Fil: Eban Rothschild, Ada. University of Michigan; Estados Unidos
description Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/254934
Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-146
0960-9822
CONICET Digital
CONICET
url http://hdl.handle.net/11336/254934
identifier_str_mv Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-146
0960-9822
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982223016524
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2023.11.065
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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