Neurophysiological and behavioral synchronization in group-living and sleeping mice
- Autores
- Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; Rothschild, Gideon; Eban Rothschild, Ada
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.
Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados Unidos
Fil: Markunas, Chelsea. University of Michigan; Estados Unidos
Fil: Kudlak, Tyler. University of Michigan; Estados Unidos
Fil: Kohtz, Chani. University of Michigan; Estados Unidos
Fil: Vyssotski, Alexei L.. Universitat Zurich; Suiza
Fil: Rothschild, Gideon. University of Michigan; Estados Unidos
Fil: Eban Rothschild, Ada. University of Michigan; Estados Unidos - Materia
-
SOCIAL CONTACT
NREM SLEEP
REM SLEEP
HUDDLING BEHAVIOR
WIRELESS TECHNOLOGY
NEUROPHYSIOLOGICAL SYNCHRONIZATION
SOMATOLONGING
IMMERSIVE SOCIAL INTERACTIONS ASSAY
PRE-SLEEP BEHAVIOR - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/254934
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Neurophysiological and behavioral synchronization in group-living and sleeping miceSotelo, María InésMarkunas, ChelseaKudlak, TylerKohtz, ChaniVyssotski, Alexei L.Rothschild, GideonEban Rothschild, AdaSOCIAL CONTACTNREM SLEEPREM SLEEPHUDDLING BEHAVIORWIRELESS TECHNOLOGYNEUROPHYSIOLOGICAL SYNCHRONIZATIONSOMATOLONGINGIMMERSIVE SOCIAL INTERACTIONS ASSAYPRE-SLEEP BEHAVIORhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep.Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados UnidosFil: Markunas, Chelsea. University of Michigan; Estados UnidosFil: Kudlak, Tyler. University of Michigan; Estados UnidosFil: Kohtz, Chani. University of Michigan; Estados UnidosFil: Vyssotski, Alexei L.. Universitat Zurich; SuizaFil: Rothschild, Gideon. University of Michigan; Estados UnidosFil: Eban Rothschild, Ada. University of Michigan; Estados UnidosCell Press2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/254934Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-1460960-9822CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982223016524info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2023.11.065info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:25:52Zoai:ri.conicet.gov.ar:11336/254934instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:25:53.227CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
title |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
spellingShingle |
Neurophysiological and behavioral synchronization in group-living and sleeping mice Sotelo, María Inés SOCIAL CONTACT NREM SLEEP REM SLEEP HUDDLING BEHAVIOR WIRELESS TECHNOLOGY NEUROPHYSIOLOGICAL SYNCHRONIZATION SOMATOLONGING IMMERSIVE SOCIAL INTERACTIONS ASSAY PRE-SLEEP BEHAVIOR |
title_short |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
title_full |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
title_fullStr |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
title_full_unstemmed |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
title_sort |
Neurophysiological and behavioral synchronization in group-living and sleeping mice |
dc.creator.none.fl_str_mv |
Sotelo, María Inés Markunas, Chelsea Kudlak, Tyler Kohtz, Chani Vyssotski, Alexei L. Rothschild, Gideon Eban Rothschild, Ada |
author |
Sotelo, María Inés |
author_facet |
Sotelo, María Inés Markunas, Chelsea Kudlak, Tyler Kohtz, Chani Vyssotski, Alexei L. Rothschild, Gideon Eban Rothschild, Ada |
author_role |
author |
author2 |
Markunas, Chelsea Kudlak, Tyler Kohtz, Chani Vyssotski, Alexei L. Rothschild, Gideon Eban Rothschild, Ada |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
SOCIAL CONTACT NREM SLEEP REM SLEEP HUDDLING BEHAVIOR WIRELESS TECHNOLOGY NEUROPHYSIOLOGICAL SYNCHRONIZATION SOMATOLONGING IMMERSIVE SOCIAL INTERACTIONS ASSAY PRE-SLEEP BEHAVIOR |
topic |
SOCIAL CONTACT NREM SLEEP REM SLEEP HUDDLING BEHAVIOR WIRELESS TECHNOLOGY NEUROPHYSIOLOGICAL SYNCHRONIZATION SOMATOLONGING IMMERSIVE SOCIAL INTERACTIONS ASSAY PRE-SLEEP BEHAVIOR |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.7 https://purl.org/becyt/ford/1 https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep. Fil: Sotelo, María Inés. Universidad de Buenos Aires. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. University of Michigan; Estados Unidos Fil: Markunas, Chelsea. University of Michigan; Estados Unidos Fil: Kudlak, Tyler. University of Michigan; Estados Unidos Fil: Kohtz, Chani. University of Michigan; Estados Unidos Fil: Vyssotski, Alexei L.. Universitat Zurich; Suiza Fil: Rothschild, Gideon. University of Michigan; Estados Unidos Fil: Eban Rothschild, Ada. University of Michigan; Estados Unidos |
description |
Social interactions profoundly influence animal development, physiology, and behavior. Yet, how sleep-a central behavioral and neurophysiological process-is modulated by social interactions is poorly understood. Here, we characterized sleep behavior and neurophysiology in freely moving and co-living mice under different social conditions. We utilized wireless neurophysiological devices to simultaneously record multiple individuals within a group for 24 h, alongside video acquisition. We first demonstrated that mice seek physical contact before sleep initiation and sleep while in close proximity to each other (hereafter, "huddling"). To determine whether huddling during sleep is a motivated behavior, we devised a novel behavioral apparatus allowing mice to choose whether to sleep in close proximity to a conspecific or in solitude, under different environmental conditions. We also applied a deep-learning-based approach to classify huddling behavior. We demonstrate that mice are willing to forgo their preferred sleep location, even under thermoneutral conditions, to gain access to social contact during sleep. This strongly suggests that the motivation for prolonged physical contact-which we term somatolonging-drives huddling behavior. We then characterized sleep architecture under different social conditions and uncovered a social-dependent modulation of sleep. We also revealed coordination in multiple neurophysiological features among co-sleeping individuals, including in the timing of falling asleep and waking up and non-rapid eye movement sleep (NREMS) intensity. Notably, the timing of rapid eye movement sleep (REMS) was synchronized among co-sleeping male siblings but not co-sleeping female or unfamiliar mice. Our findings provide novel insights into the motivation for physical contact and the extent of social-dependent plasticity in sleep. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/254934 Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-146 0960-9822 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/254934 |
identifier_str_mv |
Sotelo, María Inés; Markunas, Chelsea; Kudlak, Tyler; Kohtz, Chani; Vyssotski, Alexei L.; et al.; Neurophysiological and behavioral synchronization in group-living and sleeping mice; Cell Press; Current Biology; 34; 1; 1-2024; 132-146 0960-9822 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0960982223016524 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cub.2023.11.065 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846082698091692032 |
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13.22299 |