Socialization causes long-lasting behavioral changes
- Autores
- Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; Turiégano, Enrique; Beckwith, Esteban Javier; Martin, Francisco A.
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.
Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España
Fil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; España
Fil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; España
Fil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; España
Fil: Turiégano, Enrique. Universidad Autónoma de Madrid; España
Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina
Fil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; España - Materia
-
SOCIALIZATION
MEMORY
SLEEP
FEEDING
AGGRESSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/261097
Ver los metadatos del registro completo
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Socialization causes long-lasting behavioral changesGil Martí, BeatrizIsidro Mézcua, JuliaPoza Rodriguez, AdrianaAsti Tello, Gerson SmithTreves, GaiaTuriégano, EnriqueBeckwith, Esteban JavierMartin, Francisco A.SOCIALIZATIONMEMORYSLEEPFEEDINGAGGRESSIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation.Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; EspañaFil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; EspañaFil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; EspañaFil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; EspañaFil: Turiégano, Enrique. Universidad Autónoma de Madrid; EspañaFil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; ArgentinaFil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; EspañaCold Spring Harbor Laboratory Press2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261097Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Cold Spring Harbor Laboratory Press; bioRxiv; 5-2024; 1-242692-8205CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2024.04.25.591071v2info:eu-repo/semantics/altIdentifier/doi/10.1101/2024.04.25.591071info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:04Zoai:ri.conicet.gov.ar:11336/261097instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:05.154CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Socialization causes long-lasting behavioral changes |
title |
Socialization causes long-lasting behavioral changes |
spellingShingle |
Socialization causes long-lasting behavioral changes Gil Martí, Beatriz SOCIALIZATION MEMORY SLEEP FEEDING AGGRESSION |
title_short |
Socialization causes long-lasting behavioral changes |
title_full |
Socialization causes long-lasting behavioral changes |
title_fullStr |
Socialization causes long-lasting behavioral changes |
title_full_unstemmed |
Socialization causes long-lasting behavioral changes |
title_sort |
Socialization causes long-lasting behavioral changes |
dc.creator.none.fl_str_mv |
Gil Martí, Beatriz Isidro Mézcua, Julia Poza Rodriguez, Adriana Asti Tello, Gerson Smith Treves, Gaia Turiégano, Enrique Beckwith, Esteban Javier Martin, Francisco A. |
author |
Gil Martí, Beatriz |
author_facet |
Gil Martí, Beatriz Isidro Mézcua, Julia Poza Rodriguez, Adriana Asti Tello, Gerson Smith Treves, Gaia Turiégano, Enrique Beckwith, Esteban Javier Martin, Francisco A. |
author_role |
author |
author2 |
Isidro Mézcua, Julia Poza Rodriguez, Adriana Asti Tello, Gerson Smith Treves, Gaia Turiégano, Enrique Beckwith, Esteban Javier Martin, Francisco A. |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
SOCIALIZATION MEMORY SLEEP FEEDING AGGRESSION |
topic |
SOCIALIZATION MEMORY SLEEP FEEDING AGGRESSION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation. Fil: Gil Martí, Beatriz. Consejo Superior de Investigaciones Científicas; España. Universidad Autónoma de Madrid; España Fil: Isidro Mézcua, Julia. Consejo Superior de Investigaciones Científicas; España Fil: Poza Rodriguez, Adriana. Consejo Superior de Investigaciones Científicas; España Fil: Asti Tello, Gerson Smith. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Treves, Gaia. Consejo Superior de Investigaciones Científicas; España Fil: Turiégano, Enrique. Universidad Autónoma de Madrid; España Fil: Beckwith, Esteban Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina Fil: Martin, Francisco A.. Consejo Superior de Investigaciones Científicas; España |
description |
In modern human societies, social isolation acts as a negative factor for health and life quality. On the other hand, social interaction also has profound effects on animal and human behaviors, reducing aggressiveness, feeding and loss of sleep. Here, we observe that in the fly Drosophila melanogaster these behavioral changes long-last even after social interaction has ceased, suggesting that the socialization experience triggers behavioral plasticity. We find that impairing long-term memory mechanisms either genetically or by anesthesia abolishes the expected behavioral changes in response to social interaction. Furthermore, we show that socialization increases CREB-dependent neuronal activity and synaptic plasticity in the mushroom body, the main insect memory center analogous to mammalian hippocampus. We propose that social interaction triggers socialization awareness, understood as long-lasting changes in behavior caused by experience with mechanistic similarities to long-term memory formation. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/261097 Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Cold Spring Harbor Laboratory Press; bioRxiv; 5-2024; 1-24 2692-8205 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/261097 |
identifier_str_mv |
Gil Martí, Beatriz; Isidro Mézcua, Julia; Poza Rodriguez, Adriana; Asti Tello, Gerson Smith; Treves, Gaia; et al.; Socialization causes long-lasting behavioral changes; Cold Spring Harbor Laboratory Press; bioRxiv; 5-2024; 1-24 2692-8205 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.biorxiv.org/content/10.1101/2024.04.25.591071v2 info:eu-repo/semantics/altIdentifier/doi/10.1101/2024.04.25.591071 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
publisher.none.fl_str_mv |
Cold Spring Harbor Laboratory Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613417772515328 |
score |
13.070432 |