Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data
- Autores
- Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; Rueda, Antonio López; Roman, Luis San; Remollo, Sebastian; Marinelli, Claudia Beatriz; Cepeda, Rosana; Fernández, Héctor; Larrabide, Ignacio
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required.
Fil: Narata, Ana Paula. Hôpitaux de Tours; Francia
Fil: Obradó, Laura. Galgo Medical S. L.; España
Fil: Moyano, Raquel Kalé. Galgo Medical S. L.; España
Fil: Macho, Juan M.. Hospital Clinic of Barcelona; España
Fil: Blasco, Jordi. Hospital Clinic of Barcelona; España
Fil: Rueda, Antonio López. Hospital Clinic of Barcelona; España
Fil: Roman, Luis San. Hospital Clinic of Barcelona; España
Fil: Remollo, Sebastian. Hospital Universitari Germans Trias i Pujol; España
Fil: Marinelli, Claudia Beatriz. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
Fil: Cepeda, Rosana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina
Fil: Fernández, Héctor. Galgo Medical S. L.; España
Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Galgo Medical S. L.; España - Materia
-
CEREBRAL ANEURYSMS
FLOW DIVERTER
DEVICE SIZING
DEVICE POROSITY
TIME-TO-OCCLUSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/164520
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oai:ri.conicet.gov.ar:11336/164520 |
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CONICETDig |
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3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world dataNarata, Ana PaulaObradó, LauraMoyano, Raquel KaléMacho, Juan M.Blasco, JordiRueda, Antonio LópezRoman, Luis SanRemollo, SebastianMarinelli, Claudia BeatrizCepeda, RosanaFernández, HéctorLarrabide, IgnacioCEREBRAL ANEURYSMSFLOW DIVERTERDEVICE SIZINGDEVICE POROSITYTIME-TO-OCCLUSIONhttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required.Fil: Narata, Ana Paula. Hôpitaux de Tours; FranciaFil: Obradó, Laura. Galgo Medical S. L.; EspañaFil: Moyano, Raquel Kalé. Galgo Medical S. L.; EspañaFil: Macho, Juan M.. Hospital Clinic of Barcelona; EspañaFil: Blasco, Jordi. Hospital Clinic of Barcelona; EspañaFil: Rueda, Antonio López. Hospital Clinic of Barcelona; EspañaFil: Roman, Luis San. Hospital Clinic of Barcelona; EspañaFil: Remollo, Sebastian. Hospital Universitari Germans Trias i Pujol; EspañaFil: Marinelli, Claudia Beatriz. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: Cepeda, Rosana. Universidad Nacional del Centro de la Provincia de Buenos Aires; ArgentinaFil: Fernández, Héctor. Galgo Medical S. L.; EspañaFil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Galgo Medical S. L.; EspañaFrontiers Media2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/164520Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-112673-3129CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmedt.2021.705003/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fmedt.2021.705003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:59:06Zoai:ri.conicet.gov.ar:11336/164520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:59:06.991CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
title |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
spellingShingle |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data Narata, Ana Paula CEREBRAL ANEURYSMS FLOW DIVERTER DEVICE SIZING DEVICE POROSITY TIME-TO-OCCLUSION |
title_short |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
title_full |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
title_fullStr |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
title_full_unstemmed |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
title_sort |
Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data |
dc.creator.none.fl_str_mv |
Narata, Ana Paula Obradó, Laura Moyano, Raquel Kalé Macho, Juan M. Blasco, Jordi Rueda, Antonio López Roman, Luis San Remollo, Sebastian Marinelli, Claudia Beatriz Cepeda, Rosana Fernández, Héctor Larrabide, Ignacio |
author |
Narata, Ana Paula |
author_facet |
Narata, Ana Paula Obradó, Laura Moyano, Raquel Kalé Macho, Juan M. Blasco, Jordi Rueda, Antonio López Roman, Luis San Remollo, Sebastian Marinelli, Claudia Beatriz Cepeda, Rosana Fernández, Héctor Larrabide, Ignacio |
author_role |
author |
author2 |
Obradó, Laura Moyano, Raquel Kalé Macho, Juan M. Blasco, Jordi Rueda, Antonio López Roman, Luis San Remollo, Sebastian Marinelli, Claudia Beatriz Cepeda, Rosana Fernández, Héctor Larrabide, Ignacio |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CEREBRAL ANEURYSMS FLOW DIVERTER DEVICE SIZING DEVICE POROSITY TIME-TO-OCCLUSION |
topic |
CEREBRAL ANEURYSMS FLOW DIVERTER DEVICE SIZING DEVICE POROSITY TIME-TO-OCCLUSION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.2 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required. Fil: Narata, Ana Paula. Hôpitaux de Tours; Francia Fil: Obradó, Laura. Galgo Medical S. L.; España Fil: Moyano, Raquel Kalé. Galgo Medical S. L.; España Fil: Macho, Juan M.. Hospital Clinic of Barcelona; España Fil: Blasco, Jordi. Hospital Clinic of Barcelona; España Fil: Rueda, Antonio López. Hospital Clinic of Barcelona; España Fil: Roman, Luis San. Hospital Clinic of Barcelona; España Fil: Remollo, Sebastian. Hospital Universitari Germans Trias i Pujol; España Fil: Marinelli, Claudia Beatriz. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina Fil: Cepeda, Rosana. Universidad Nacional del Centro de la Provincia de Buenos Aires; Argentina Fil: Fernández, Héctor. Galgo Medical S. L.; España Fil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentina. Galgo Medical S. L.; España |
description |
Background: Flow-Diverter (FD) porosity has been pointed as a critical factor in theocclusion of cerebral aneurysms after treatment.Objective: Verification and Validation of computational models in terms of predictivecapacity, relating FD porosity and occlusion after cerebral aneurysms treatment.Methods: Sixty-four aneurysms, with pre-treatment and follow-up images, wereconsidered. Patient demographics and aneurysm morphological information werecollected. The computational simulation provided by ANKYRAS provided FD porosity,expansion, and mesh angle. FD occlusion was assessed and recorded from follow-upimages. Multiple regression Logit and analysis of covariance (ANCOVA) models wereused to model the data with both categorical and continuous models.Results: Occlusion of the aneurysm after 12 months was affected by aneurysmmorphology but not by FD mesh morphology. A Time-To-Occlusion (TTO) of 6.92 monthson average was observed with an SE of 0.24 months in the aneurysm populationsurveyed. TTO was estimated with statistical significance from the resulting model forthe data examined and was capable of explaining 92% of the data variation.Conclusions: Porosity was found to have the most correction power when assessingTTO, proving its importance in the process of aneurysm occlusion. Still, further Verificationand Validation (V&V) of treatment simulation in more extensive, multi-center, andrandomized databases is required. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-09 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/164520 Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-11 2673-3129 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/164520 |
identifier_str_mv |
Narata, Ana Paula; Obradó, Laura; Moyano, Raquel Kalé; Macho, Juan M.; Blasco, Jordi; et al.; Cerebral aneurysm occlusion at 12-month follow-up after flow-diverter treatment: statistical modeling for V&V with real-world data; Frontiers Media; Frontiers in Medical Technology; 3; 9-2021; 1-11 2673-3129 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fmedt.2021.705003/full info:eu-repo/semantics/altIdentifier/doi/10.3389/fmedt.2021.705003 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Frontiers Media |
publisher.none.fl_str_mv |
Frontiers Media |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613756433203200 |
score |
13.070432 |