Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations

Autores
Castro, Marcelo Adrian; Putman, Christopher M.; Cebral, Juan Raúl
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anterior communicating artery (AComA) is a unique vascular location that receives blood from two sources of inflow and redistributes it toward the anterior part of the brain through two efferent arteries. It is widely accepted that complexity in the flow pattern is associated with the high rate of aneurysm formation in that location observed in large studies. A previous computational hemodynamic study showed a possible association between high maximum intraaneurysmal wall shear stress (WSS) at the systolic peak with rupture in a cohort of AComA aneurysms. In another study it was observed a connection between location of aneurysm blebs and regions of high WSS in models where blebs were virtually removed. The purpose of this work is to study associations between hemodynamic patterns and AComA aneurysm initiation by comparing hemodynamics between the aneurysm models and the normal model where the aneurysm was computationally removed. Vascular models of both right and left circulation were independently reconstructed from three-dimensional rotational angiography images using deformable models after image registration of both images, and later fused using a surface merging algorithm. Afterwards, the geometric models were used to generate high-quality volumetric finite element grids composed several million tetrahedral elements with an advancing front technique. For each patient the second anatomical model was created by digitally removing the aneurysm. It was iteratively achieved by applying a Laplacian smoothing filter and remeshing the surface. Finite element blood flow numerical simulations were performed for both the pathological and normal models under the same flow conditions. Personalized pulsatile flow conditions were imposed at the inlets of both models with use of the Womersley solution. The Navier-Stokes equations were numerically integrated by using a fully implicit finite-element formulation. From analysis of WSS distributions it was observed that aneurysms initiated in regions of high and moderate WSS in the counterpart normal models. Adjacent or close to those regions, low WSS portions of the arterial wall were not affected by the disease. These results are in line with previous reported observations at other vascular locations.
Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. George Mason University; Estados Unidos
Fil: Putman, Christopher M.. Inova Fairfax Hospital; Estados Unidos
Fil: Cebral, Juan Raúl. George Mason University; Estados Unidos
Materia
Cerebral aneurysms
Anterior communicating artery
Numerical simulations
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/195835

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spelling Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulationsCastro, Marcelo AdrianPutman, Christopher M.Cebral, Juan RaúlCerebral aneurysmsAnterior communicating arteryNumerical simulationshttps://purl.org/becyt/ford/2.11https://purl.org/becyt/ford/2The anterior communicating artery (AComA) is a unique vascular location that receives blood from two sources of inflow and redistributes it toward the anterior part of the brain through two efferent arteries. It is widely accepted that complexity in the flow pattern is associated with the high rate of aneurysm formation in that location observed in large studies. A previous computational hemodynamic study showed a possible association between high maximum intraaneurysmal wall shear stress (WSS) at the systolic peak with rupture in a cohort of AComA aneurysms. In another study it was observed a connection between location of aneurysm blebs and regions of high WSS in models where blebs were virtually removed. The purpose of this work is to study associations between hemodynamic patterns and AComA aneurysm initiation by comparing hemodynamics between the aneurysm models and the normal model where the aneurysm was computationally removed. Vascular models of both right and left circulation were independently reconstructed from three-dimensional rotational angiography images using deformable models after image registration of both images, and later fused using a surface merging algorithm. Afterwards, the geometric models were used to generate high-quality volumetric finite element grids composed several million tetrahedral elements with an advancing front technique. For each patient the second anatomical model was created by digitally removing the aneurysm. It was iteratively achieved by applying a Laplacian smoothing filter and remeshing the surface. Finite element blood flow numerical simulations were performed for both the pathological and normal models under the same flow conditions. Personalized pulsatile flow conditions were imposed at the inlets of both models with use of the Womersley solution. The Navier-Stokes equations were numerically integrated by using a fully implicit finite-element formulation. From analysis of WSS distributions it was observed that aneurysms initiated in regions of high and moderate WSS in the counterpart normal models. Adjacent or close to those regions, low WSS portions of the arterial wall were not affected by the disease. These results are in line with previous reported observations at other vascular locations.Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. George Mason University; Estados UnidosFil: Putman, Christopher M.. Inova Fairfax Hospital; Estados UnidosFil: Cebral, Juan Raúl. George Mason University; Estados UnidosAsociación Argentina de Mecánica Computacional2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195835Castro, Marcelo Adrian; Putman, Christopher M.; Cebral, Juan Raúl; Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations; Asociación Argentina de Mecánica Computacional; Mecanica Computacional; 30; 44; 11-2011; 3385-33931666-60702591-3522CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.cimec.org.ar/ojs/index.php/mc/article/viewFile/3992/3909info:eu-repo/semantics/altIdentifier/url/http://venus.ceride.gov.ar/ojs/index.php/mc/article/view/3992info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:09:51Zoai:ri.conicet.gov.ar:11336/195835instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:09:51.854CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
title Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
spellingShingle Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
Castro, Marcelo Adrian
Cerebral aneurysms
Anterior communicating artery
Numerical simulations
title_short Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
title_full Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
title_fullStr Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
title_full_unstemmed Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
title_sort Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations
dc.creator.none.fl_str_mv Castro, Marcelo Adrian
Putman, Christopher M.
Cebral, Juan Raúl
author Castro, Marcelo Adrian
author_facet Castro, Marcelo Adrian
Putman, Christopher M.
Cebral, Juan Raúl
author_role author
author2 Putman, Christopher M.
Cebral, Juan Raúl
author2_role author
author
dc.subject.none.fl_str_mv Cerebral aneurysms
Anterior communicating artery
Numerical simulations
topic Cerebral aneurysms
Anterior communicating artery
Numerical simulations
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.11
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The anterior communicating artery (AComA) is a unique vascular location that receives blood from two sources of inflow and redistributes it toward the anterior part of the brain through two efferent arteries. It is widely accepted that complexity in the flow pattern is associated with the high rate of aneurysm formation in that location observed in large studies. A previous computational hemodynamic study showed a possible association between high maximum intraaneurysmal wall shear stress (WSS) at the systolic peak with rupture in a cohort of AComA aneurysms. In another study it was observed a connection between location of aneurysm blebs and regions of high WSS in models where blebs were virtually removed. The purpose of this work is to study associations between hemodynamic patterns and AComA aneurysm initiation by comparing hemodynamics between the aneurysm models and the normal model where the aneurysm was computationally removed. Vascular models of both right and left circulation were independently reconstructed from three-dimensional rotational angiography images using deformable models after image registration of both images, and later fused using a surface merging algorithm. Afterwards, the geometric models were used to generate high-quality volumetric finite element grids composed several million tetrahedral elements with an advancing front technique. For each patient the second anatomical model was created by digitally removing the aneurysm. It was iteratively achieved by applying a Laplacian smoothing filter and remeshing the surface. Finite element blood flow numerical simulations were performed for both the pathological and normal models under the same flow conditions. Personalized pulsatile flow conditions were imposed at the inlets of both models with use of the Womersley solution. The Navier-Stokes equations were numerically integrated by using a fully implicit finite-element formulation. From analysis of WSS distributions it was observed that aneurysms initiated in regions of high and moderate WSS in the counterpart normal models. Adjacent or close to those regions, low WSS portions of the arterial wall were not affected by the disease. These results are in line with previous reported observations at other vascular locations.
Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. George Mason University; Estados Unidos
Fil: Putman, Christopher M.. Inova Fairfax Hospital; Estados Unidos
Fil: Cebral, Juan Raúl. George Mason University; Estados Unidos
description The anterior communicating artery (AComA) is a unique vascular location that receives blood from two sources of inflow and redistributes it toward the anterior part of the brain through two efferent arteries. It is widely accepted that complexity in the flow pattern is associated with the high rate of aneurysm formation in that location observed in large studies. A previous computational hemodynamic study showed a possible association between high maximum intraaneurysmal wall shear stress (WSS) at the systolic peak with rupture in a cohort of AComA aneurysms. In another study it was observed a connection between location of aneurysm blebs and regions of high WSS in models where blebs were virtually removed. The purpose of this work is to study associations between hemodynamic patterns and AComA aneurysm initiation by comparing hemodynamics between the aneurysm models and the normal model where the aneurysm was computationally removed. Vascular models of both right and left circulation were independently reconstructed from three-dimensional rotational angiography images using deformable models after image registration of both images, and later fused using a surface merging algorithm. Afterwards, the geometric models were used to generate high-quality volumetric finite element grids composed several million tetrahedral elements with an advancing front technique. For each patient the second anatomical model was created by digitally removing the aneurysm. It was iteratively achieved by applying a Laplacian smoothing filter and remeshing the surface. Finite element blood flow numerical simulations were performed for both the pathological and normal models under the same flow conditions. Personalized pulsatile flow conditions were imposed at the inlets of both models with use of the Womersley solution. The Navier-Stokes equations were numerically integrated by using a fully implicit finite-element formulation. From analysis of WSS distributions it was observed that aneurysms initiated in regions of high and moderate WSS in the counterpart normal models. Adjacent or close to those regions, low WSS portions of the arterial wall were not affected by the disease. These results are in line with previous reported observations at other vascular locations.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/195835
Castro, Marcelo Adrian; Putman, Christopher M.; Cebral, Juan Raúl; Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations; Asociación Argentina de Mecánica Computacional; Mecanica Computacional; 30; 44; 11-2011; 3385-3393
1666-6070
2591-3522
CONICET Digital
CONICET
url http://hdl.handle.net/11336/195835
identifier_str_mv Castro, Marcelo Adrian; Putman, Christopher M.; Cebral, Juan Raúl; Hemodynamic characteristics at anterior communicating artery before aneurysm initiation using patient-specific finite element blood flow simulations; Asociación Argentina de Mecánica Computacional; Mecanica Computacional; 30; 44; 11-2011; 3385-3393
1666-6070
2591-3522
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/url/http://venus.ceride.gov.ar/ojs/index.php/mc/article/view/3992
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Mecánica Computacional
publisher.none.fl_str_mv Asociación Argentina de Mecánica Computacional
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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