Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study

Autores
Castro, Marcelo Adrian; Peloc, Nora Luz; Putman, Christopher M.; Cebral, Juan Raúl
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cerebral aneurysms may rarely coexist with a proximal artery stenosis. In that small percent of patients, such coexistence poses a challenge for interventional neuroradiologists and neurosurgeons to make the best treatment decision. According to previous studies, the incidence of cerebral aneurysms in patients with internal carotid artery stenosis is not greater than 5%, where the aneurysm is usually incidentally detected, being 2% for aneurysms and stenoses in the same cerebral circulation. Those cases pose a difficult management decision for the physician. Case reports showed patients who died due to aneurysm rupture months after endarterectomy but before aneurysm clipping, while others did not show any change in the aneurysm after plaque removal, having optimum outcome after aneurysm coiling. The aim of this study is to investigate the intraaneurysmal hemodynamic changes before and after treatment of stenotic plaque. Virtually created moderate stenoses in vascular models of internal carotid artery aneurysm patients were considered in a number of cases reconstructed from three dimensional rotational angiography images. The strategy to create those plaques was based on parameters analyzed in a previous work where idealized models were considered, including relative distance and stenosis grade. Ipsilateral and contralateral plaques were modeled. Wall shear stress and velocity pattern were computed from finite element pulsatile blood flow simulations. The results may suggest that relative angular position may change the wall shear stress within the aneurysm sac.
Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. George Mason University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peloc, Nora Luz. Universidad Favaloro; Argentina
Fil: Putman, Christopher M.. Inova Fairfax Hospital; Estados Unidos
Fil: Cebral, Juan Raúl. George Mason University; Estados Unidos
Materia
Cerebral aneurysms
Stenosis
Numerical simulations
Rotational angiography
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43028

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network_name_str CONICET Digital (CONICET)
spelling Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD StudyCastro, Marcelo AdrianPeloc, Nora LuzPutman, Christopher M.Cebral, Juan RaúlCerebral aneurysmsStenosisNumerical simulationsRotational angiographyhttps://purl.org/becyt/ford/2.6https://purl.org/becyt/ford/2Cerebral aneurysms may rarely coexist with a proximal artery stenosis. In that small percent of patients, such coexistence poses a challenge for interventional neuroradiologists and neurosurgeons to make the best treatment decision. According to previous studies, the incidence of cerebral aneurysms in patients with internal carotid artery stenosis is not greater than 5%, where the aneurysm is usually incidentally detected, being 2% for aneurysms and stenoses in the same cerebral circulation. Those cases pose a difficult management decision for the physician. Case reports showed patients who died due to aneurysm rupture months after endarterectomy but before aneurysm clipping, while others did not show any change in the aneurysm after plaque removal, having optimum outcome after aneurysm coiling. The aim of this study is to investigate the intraaneurysmal hemodynamic changes before and after treatment of stenotic plaque. Virtually created moderate stenoses in vascular models of internal carotid artery aneurysm patients were considered in a number of cases reconstructed from three dimensional rotational angiography images. The strategy to create those plaques was based on parameters analyzed in a previous work where idealized models were considered, including relative distance and stenosis grade. Ipsilateral and contralateral plaques were modeled. Wall shear stress and velocity pattern were computed from finite element pulsatile blood flow simulations. The results may suggest that relative angular position may change the wall shear stress within the aneurysm sac.Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. George Mason University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Peloc, Nora Luz. Universidad Favaloro; ArgentinaFil: Putman, Christopher M.. Inova Fairfax Hospital; Estados UnidosFil: Cebral, Juan Raúl. George Mason University; Estados UnidosAsociación Argentina de Mecánica Computacional2014-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43028Castro, Marcelo Adrian; Peloc, Nora Luz; Putman, Christopher M.; Cebral, Juan Raúl; Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study; Asociación Argentina de Mecánica Computacional; Mecánica Computacional; XXXIII; 41; 9-2014; 2677-26872591-3522CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://cimec.org.ar/ojs/index.php/mc/article/view/4861info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:33:19Zoai:ri.conicet.gov.ar:11336/43028instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:33:19.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
title Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
spellingShingle Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
Castro, Marcelo Adrian
Cerebral aneurysms
Stenosis
Numerical simulations
Rotational angiography
title_short Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
title_full Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
title_fullStr Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
title_full_unstemmed Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
title_sort Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study
dc.creator.none.fl_str_mv Castro, Marcelo Adrian
Peloc, Nora Luz
Putman, Christopher M.
Cebral, Juan Raúl
author Castro, Marcelo Adrian
author_facet Castro, Marcelo Adrian
Peloc, Nora Luz
Putman, Christopher M.
Cebral, Juan Raúl
author_role author
author2 Peloc, Nora Luz
Putman, Christopher M.
Cebral, Juan Raúl
author2_role author
author
author
dc.subject.none.fl_str_mv Cerebral aneurysms
Stenosis
Numerical simulations
Rotational angiography
topic Cerebral aneurysms
Stenosis
Numerical simulations
Rotational angiography
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.6
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Cerebral aneurysms may rarely coexist with a proximal artery stenosis. In that small percent of patients, such coexistence poses a challenge for interventional neuroradiologists and neurosurgeons to make the best treatment decision. According to previous studies, the incidence of cerebral aneurysms in patients with internal carotid artery stenosis is not greater than 5%, where the aneurysm is usually incidentally detected, being 2% for aneurysms and stenoses in the same cerebral circulation. Those cases pose a difficult management decision for the physician. Case reports showed patients who died due to aneurysm rupture months after endarterectomy but before aneurysm clipping, while others did not show any change in the aneurysm after plaque removal, having optimum outcome after aneurysm coiling. The aim of this study is to investigate the intraaneurysmal hemodynamic changes before and after treatment of stenotic plaque. Virtually created moderate stenoses in vascular models of internal carotid artery aneurysm patients were considered in a number of cases reconstructed from three dimensional rotational angiography images. The strategy to create those plaques was based on parameters analyzed in a previous work where idealized models were considered, including relative distance and stenosis grade. Ipsilateral and contralateral plaques were modeled. Wall shear stress and velocity pattern were computed from finite element pulsatile blood flow simulations. The results may suggest that relative angular position may change the wall shear stress within the aneurysm sac.
Fil: Castro, Marcelo Adrian. Universidad Tecnológica Nacional. Facultad Regional Buenos Aires; Argentina. George Mason University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Peloc, Nora Luz. Universidad Favaloro; Argentina
Fil: Putman, Christopher M.. Inova Fairfax Hospital; Estados Unidos
Fil: Cebral, Juan Raúl. George Mason University; Estados Unidos
description Cerebral aneurysms may rarely coexist with a proximal artery stenosis. In that small percent of patients, such coexistence poses a challenge for interventional neuroradiologists and neurosurgeons to make the best treatment decision. According to previous studies, the incidence of cerebral aneurysms in patients with internal carotid artery stenosis is not greater than 5%, where the aneurysm is usually incidentally detected, being 2% for aneurysms and stenoses in the same cerebral circulation. Those cases pose a difficult management decision for the physician. Case reports showed patients who died due to aneurysm rupture months after endarterectomy but before aneurysm clipping, while others did not show any change in the aneurysm after plaque removal, having optimum outcome after aneurysm coiling. The aim of this study is to investigate the intraaneurysmal hemodynamic changes before and after treatment of stenotic plaque. Virtually created moderate stenoses in vascular models of internal carotid artery aneurysm patients were considered in a number of cases reconstructed from three dimensional rotational angiography images. The strategy to create those plaques was based on parameters analyzed in a previous work where idealized models were considered, including relative distance and stenosis grade. Ipsilateral and contralateral plaques were modeled. Wall shear stress and velocity pattern were computed from finite element pulsatile blood flow simulations. The results may suggest that relative angular position may change the wall shear stress within the aneurysm sac.
publishDate 2014
dc.date.none.fl_str_mv 2014-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43028
Castro, Marcelo Adrian; Peloc, Nora Luz; Putman, Christopher M.; Cebral, Juan Raúl; Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study; Asociación Argentina de Mecánica Computacional; Mecánica Computacional; XXXIII; 41; 9-2014; 2677-2687
2591-3522
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43028
identifier_str_mv Castro, Marcelo Adrian; Peloc, Nora Luz; Putman, Christopher M.; Cebral, Juan Raúl; Effects of Stenotic Plaques in Realistic Carotid Artery Aneurysm Models: a CFD Study; Asociación Argentina de Mecánica Computacional; Mecánica Computacional; XXXIII; 41; 9-2014; 2677-2687
2591-3522
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://cimec.org.ar/ojs/index.php/mc/article/view/4861
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Asociación Argentina de Mecánica Computacional
publisher.none.fl_str_mv Asociación Argentina de Mecánica Computacional
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432