Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles

Autores
Knopoff, Damián Alejandro; Nieto, Juanjo; Urrutia, Luis
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work, we deal with a kinetic model of cell movement that takes into consideration the structure of the extracellular matrix, considering cell membrane reactions, haptotaxis, and chemotaxis, which plays a key role in a number of biological processes such as wound healing and tumor cell invasion. The modeling is performed at a microscopic scale, and then, a scaling limit is performed to derive the macroscopic model. We run some selected numerical experiments aimed at understanding cell movement and adhesion under certain documented situations, and we measure the alignment of the cells and compare it with the pathways determined by the extracellular matrix by introducing new alignment operators.
Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Nieto, Juanjo. Universidad de Granada; España
Fil: Urrutia, Luis. Universidad de Granada; España
Materia
CELL MOVEMENT
HAPTOTAXIS
KINETIC THEORY
MULTISCALE MODELING
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/124677
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/124677
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particlesKnopoff, Damián AlejandroNieto, JuanjoUrrutia, LuisCELL MOVEMENTHAPTOTAXISKINETIC THEORYMULTISCALE MODELINGhttps://purl.org/becyt/ford/1.1https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1In this work, we deal with a kinetic model of cell movement that takes into consideration the structure of the extracellular matrix, considering cell membrane reactions, haptotaxis, and chemotaxis, which plays a key role in a number of biological processes such as wound healing and tumor cell invasion. The modeling is performed at a microscopic scale, and then, a scaling limit is performed to derive the macroscopic model. We run some selected numerical experiments aimed at understanding cell movement and adhesion under certain documented situations, and we measure the alignment of the cells and compare it with the pathways determined by the extracellular matrix by introducing new alignment operators.Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; ArgentinaFil: Nieto, Juanjo. Universidad de Granada; EspañaFil: Urrutia, Luis. Universidad de Granada; EspañaMDPI2019-08-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/124677Knopoff, Damián Alejandro; Nieto, Juanjo; Urrutia, Luis; Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles; MDPI; Symmetry; 11; 8; 3-8-2019; 10032073-8994CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-8994/11/8/1003info:eu-repo/semantics/altIdentifier/doi/10.3390/sym11081003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:39Zoai:ri.conicet.gov.ar:11336/124677instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:40.127CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
title Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
spellingShingle Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
Knopoff, Damián Alejandro
CELL MOVEMENT
HAPTOTAXIS
KINETIC THEORY
MULTISCALE MODELING
title_short Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
title_full Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
title_fullStr Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
title_full_unstemmed Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
title_sort Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles
dc.creator.none.fl_str_mv Knopoff, Damián Alejandro
Nieto, Juanjo
Urrutia, Luis
author Knopoff, Damián Alejandro
author_facet Knopoff, Damián Alejandro
Nieto, Juanjo
Urrutia, Luis
author_role author
author2 Nieto, Juanjo
Urrutia, Luis
author2_role author
author
dc.subject.none.fl_str_mv CELL MOVEMENT
HAPTOTAXIS
KINETIC THEORY
MULTISCALE MODELING
topic CELL MOVEMENT
HAPTOTAXIS
KINETIC THEORY
MULTISCALE MODELING
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.1
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work, we deal with a kinetic model of cell movement that takes into consideration the structure of the extracellular matrix, considering cell membrane reactions, haptotaxis, and chemotaxis, which plays a key role in a number of biological processes such as wound healing and tumor cell invasion. The modeling is performed at a microscopic scale, and then, a scaling limit is performed to derive the macroscopic model. We run some selected numerical experiments aimed at understanding cell movement and adhesion under certain documented situations, and we measure the alignment of the cells and compare it with the pathways determined by the extracellular matrix by introducing new alignment operators.
Fil: Knopoff, Damián Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigación y Estudios de Matemática. Universidad Nacional de Córdoba. Centro de Investigación y Estudios de Matemática; Argentina
Fil: Nieto, Juanjo. Universidad de Granada; España
Fil: Urrutia, Luis. Universidad de Granada; España
description In this work, we deal with a kinetic model of cell movement that takes into consideration the structure of the extracellular matrix, considering cell membrane reactions, haptotaxis, and chemotaxis, which plays a key role in a number of biological processes such as wound healing and tumor cell invasion. The modeling is performed at a microscopic scale, and then, a scaling limit is performed to derive the macroscopic model. We run some selected numerical experiments aimed at understanding cell movement and adhesion under certain documented situations, and we measure the alignment of the cells and compare it with the pathways determined by the extracellular matrix by introducing new alignment operators.
publishDate 2019
dc.date.none.fl_str_mv 2019-08-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/124677
Knopoff, Damián Alejandro; Nieto, Juanjo; Urrutia, Luis; Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles; MDPI; Symmetry; 11; 8; 3-8-2019; 1003
2073-8994
CONICET Digital
CONICET
url http://hdl.handle.net/11336/124677
identifier_str_mv Knopoff, Damián Alejandro; Nieto, Juanjo; Urrutia, Luis; Numerical simulation of a multiscale cell motility model based on the kinetic theory of active particles; MDPI; Symmetry; 11; 8; 3-8-2019; 1003
2073-8994
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2073-8994/11/8/1003
info:eu-repo/semantics/altIdentifier/doi/10.3390/sym11081003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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