Congenital Zika syndrome is associated with maternal protein malnutrition
- Autores
- Barbeito Andrés, Jimena; Pezzuto, Paula; Higa, Luiza; Dias, André Alves; Vasconcelos, Janaina; Santos, T. M. P.; Ferreira, Jéssica; Ferreira, R. O.; Dutra, F. F.; Rossi, A. D.; Barbosa, R. V.; Amorim, C. K. N.; de Souza, M. P. C.; Chimelli, L.; Aguiar, R. S.; Gonzalez, Paula Natalia; Lara, F. A.; Castro, M.C.; Molnár, Z.; Lopes, R. T.; Bozza, M. T.; Vianez, J. L. S. G.; Barbeito, Claudio Gustavo; Cuervo, P.; Bellio, M.; Tanuri, A.; Garcez, P. P.
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.
Fil: Barbeito Andrés, Jimena. Universidade Federal do Rio de Janeiro; Brasil. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Pezzuto, Paula. Universidade Federal do Rio de Janeiro; Brasil
Fil: Higa, Luiza. Universidade Federal do Rio de Janeiro; Brasil
Fil: Dias, André Alves. Universidade Federal do Rio de Janeiro; Brasil
Fil: Vasconcelos, Janaina. Universidade Federal do Pará; Brasil
Fil: Santos, T. M. P.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Ferreira, Jéssica. Universidade Federal do Rio de Janeiro; Brasil
Fil: Ferreira, R. O.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Dutra, F. F.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Rossi, A. D.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Barbosa, R. V.. Universidade Federal Do Rio de Janeiro. Centro Nacional de Biologia Estrutural E Bioimagem.; Brasil
Fil: Amorim, C. K. N.. Evandro Chagas Institute; Brasil
Fil: de Souza, M. P. C.. Evandro Chagas Institute; Brasil
Fil: Chimelli, L.. Instituto Estadual do Cérebro Paulo Niemeyer ; Brasil
Fil: Aguiar, R. S.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Lara, F. A.. Oswaldo Cruz Institute; Brasil
Fil: Castro, M.C.. Harvard University. Harvard School of Public Health; Estados Unidos
Fil: Molnár, Z.. University of Oxford; Reino Unido
Fil: Lopes, R. T.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Bozza, M. T.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Vianez, J. L. S. G.. Evandro Chagas Institute; Brasil
Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
Fil: Cuervo, P.. Oswaldo Cruz Institute; Brasil
Fil: Bellio, M.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Tanuri, A.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Garcez, P. P.. Universidade Federal do Rio de Janeiro; Brasil - Materia
-
MORPHOMETRICS
IMMUNOHISTOCHEMISTRY
BRAIN DEVELOPMENT - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/131438
Ver los metadatos del registro completo
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Congenital Zika syndrome is associated with maternal protein malnutritionBarbeito Andrés, JimenaPezzuto, PaulaHiga, LuizaDias, André AlvesVasconcelos, JanainaSantos, T. M. P.Ferreira, JéssicaFerreira, R. O.Dutra, F. F.Rossi, A. D.Barbosa, R. V.Amorim, C. K. N.de Souza, M. P. C.Chimelli, L.Aguiar, R. S.Gonzalez, Paula NataliaLara, F. A.Castro, M.C.Molnár, Z.Lopes, R. T.Bozza, M. T.Vianez, J. L. S. G.Barbeito, Claudio GustavoCuervo, P.Bellio, M.Tanuri, A.Garcez, P. P.MORPHOMETRICSIMMUNOHISTOCHEMISTRYBRAIN DEVELOPMENThttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS.Fil: Barbeito Andrés, Jimena. Universidade Federal do Rio de Janeiro; Brasil. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Pezzuto, Paula. Universidade Federal do Rio de Janeiro; BrasilFil: Higa, Luiza. Universidade Federal do Rio de Janeiro; BrasilFil: Dias, André Alves. Universidade Federal do Rio de Janeiro; BrasilFil: Vasconcelos, Janaina. Universidade Federal do Pará; BrasilFil: Santos, T. M. P.. Universidade Federal do Rio de Janeiro; BrasilFil: Ferreira, Jéssica. Universidade Federal do Rio de Janeiro; BrasilFil: Ferreira, R. O.. Universidade Federal do Rio de Janeiro; BrasilFil: Dutra, F. F.. Universidade Federal do Rio de Janeiro; BrasilFil: Rossi, A. D.. Universidade Federal do Rio de Janeiro; BrasilFil: Barbosa, R. V.. Universidade Federal Do Rio de Janeiro. Centro Nacional de Biologia Estrutural E Bioimagem.; BrasilFil: Amorim, C. K. N.. Evandro Chagas Institute; BrasilFil: de Souza, M. P. C.. Evandro Chagas Institute; BrasilFil: Chimelli, L.. Instituto Estadual do Cérebro Paulo Niemeyer ; BrasilFil: Aguiar, R. S.. Universidade Federal do Rio de Janeiro; BrasilFil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Lara, F. A.. Oswaldo Cruz Institute; BrasilFil: Castro, M.C.. Harvard University. Harvard School of Public Health; Estados UnidosFil: Molnár, Z.. University of Oxford; Reino UnidoFil: Lopes, R. T.. Universidade Federal do Rio de Janeiro; BrasilFil: Bozza, M. T.. Universidade Federal do Rio de Janeiro; BrasilFil: Vianez, J. L. S. G.. Evandro Chagas Institute; BrasilFil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Cuervo, P.. Oswaldo Cruz Institute; BrasilFil: Bellio, M.. Universidade Federal do Rio de Janeiro; BrasilFil: Tanuri, A.. Universidade Federal do Rio de Janeiro; BrasilFil: Garcez, P. P.. Universidade Federal do Rio de Janeiro; BrasilScience Advances is the American Association for the Advancement of Science2020-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/131438Barbeito Andrés, Jimena; Pezzuto, Paula; Higa, Luiza; Dias, André Alves; Vasconcelos, Janaina; et al.; Congenital Zika syndrome is associated with maternal protein malnutrition; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 2; 1-2020; 1-132375-2548CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://advances.sciencemag.org/lookup/doi/10.1126/sciadv.aaw6284info:eu-repo/semantics/altIdentifier/doi/10.1126/sciadv.aaw6284info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:51:46Zoai:ri.conicet.gov.ar:11336/131438instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:51:46.443CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| spellingShingle |
Congenital Zika syndrome is associated with maternal protein malnutrition Barbeito Andrés, Jimena MORPHOMETRICS IMMUNOHISTOCHEMISTRY BRAIN DEVELOPMENT |
| title_short |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_full |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_fullStr |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_full_unstemmed |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| title_sort |
Congenital Zika syndrome is associated with maternal protein malnutrition |
| dc.creator.none.fl_str_mv |
Barbeito Andrés, Jimena Pezzuto, Paula Higa, Luiza Dias, André Alves Vasconcelos, Janaina Santos, T. M. P. Ferreira, Jéssica Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. de Souza, M. P. C. Chimelli, L. Aguiar, R. S. Gonzalez, Paula Natalia Lara, F. A. Castro, M.C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, Claudio Gustavo Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
| author |
Barbeito Andrés, Jimena |
| author_facet |
Barbeito Andrés, Jimena Pezzuto, Paula Higa, Luiza Dias, André Alves Vasconcelos, Janaina Santos, T. M. P. Ferreira, Jéssica Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. de Souza, M. P. C. Chimelli, L. Aguiar, R. S. Gonzalez, Paula Natalia Lara, F. A. Castro, M.C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, Claudio Gustavo Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
| author_role |
author |
| author2 |
Pezzuto, Paula Higa, Luiza Dias, André Alves Vasconcelos, Janaina Santos, T. M. P. Ferreira, Jéssica Ferreira, R. O. Dutra, F. F. Rossi, A. D. Barbosa, R. V. Amorim, C. K. N. de Souza, M. P. C. Chimelli, L. Aguiar, R. S. Gonzalez, Paula Natalia Lara, F. A. Castro, M.C. Molnár, Z. Lopes, R. T. Bozza, M. T. Vianez, J. L. S. G. Barbeito, Claudio Gustavo Cuervo, P. Bellio, M. Tanuri, A. Garcez, P. P. |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
MORPHOMETRICS IMMUNOHISTOCHEMISTRY BRAIN DEVELOPMENT |
| topic |
MORPHOMETRICS IMMUNOHISTOCHEMISTRY BRAIN DEVELOPMENT |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. Fil: Barbeito Andrés, Jimena. Universidade Federal do Rio de Janeiro; Brasil. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina Fil: Pezzuto, Paula. Universidade Federal do Rio de Janeiro; Brasil Fil: Higa, Luiza. Universidade Federal do Rio de Janeiro; Brasil Fil: Dias, André Alves. Universidade Federal do Rio de Janeiro; Brasil Fil: Vasconcelos, Janaina. Universidade Federal do Pará; Brasil Fil: Santos, T. M. P.. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferreira, Jéssica. Universidade Federal do Rio de Janeiro; Brasil Fil: Ferreira, R. O.. Universidade Federal do Rio de Janeiro; Brasil Fil: Dutra, F. F.. Universidade Federal do Rio de Janeiro; Brasil Fil: Rossi, A. D.. Universidade Federal do Rio de Janeiro; Brasil Fil: Barbosa, R. V.. Universidade Federal Do Rio de Janeiro. Centro Nacional de Biologia Estrutural E Bioimagem.; Brasil Fil: Amorim, C. K. N.. Evandro Chagas Institute; Brasil Fil: de Souza, M. P. C.. Evandro Chagas Institute; Brasil Fil: Chimelli, L.. Instituto Estadual do Cérebro Paulo Niemeyer ; Brasil Fil: Aguiar, R. S.. Universidade Federal do Rio de Janeiro; Brasil Fil: Gonzalez, Paula Natalia. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina Fil: Lara, F. A.. Oswaldo Cruz Institute; Brasil Fil: Castro, M.C.. Harvard University. Harvard School of Public Health; Estados Unidos Fil: Molnár, Z.. University of Oxford; Reino Unido Fil: Lopes, R. T.. Universidade Federal do Rio de Janeiro; Brasil Fil: Bozza, M. T.. Universidade Federal do Rio de Janeiro; Brasil Fil: Vianez, J. L. S. G.. Evandro Chagas Institute; Brasil Fil: Barbeito, Claudio Gustavo. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina Fil: Cuervo, P.. Oswaldo Cruz Institute; Brasil Fil: Bellio, M.. Universidade Federal do Rio de Janeiro; Brasil Fil: Tanuri, A.. Universidade Federal do Rio de Janeiro; Brasil Fil: Garcez, P. P.. Universidade Federal do Rio de Janeiro; Brasil |
| description |
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-01 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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http://hdl.handle.net/11336/131438 Barbeito Andrés, Jimena; Pezzuto, Paula; Higa, Luiza; Dias, André Alves; Vasconcelos, Janaina; et al.; Congenital Zika syndrome is associated with maternal protein malnutrition; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 2; 1-2020; 1-13 2375-2548 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/131438 |
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Barbeito Andrés, Jimena; Pezzuto, Paula; Higa, Luiza; Dias, André Alves; Vasconcelos, Janaina; et al.; Congenital Zika syndrome is associated with maternal protein malnutrition; Science Advances is the American Association for the Advancement of Science; Science Advances; 6; 2; 1-2020; 1-13 2375-2548 CONICET Digital CONICET |
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eng |
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eng |
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