Why is congenital Zika syndrome asymmetrically distributed among human populations?

Autores
Barbeito Andrés, Jimena; Schuler Faccini, Lavínia; Garcez, Patricia Pestana
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Schuler-Faccini, Lavínia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Garcez, Patricia Pestana. Universidade Federal do Rio de Janeiro; Brasil
Materia
BRAIN
DEVELOPMENT
STORCH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96440
Acceder
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spelling Why is congenital Zika syndrome asymmetrically distributed among human populations?Barbeito Andrés, JimenaSchuler Faccini, LavíniaGarcez, Patricia PestanaBRAINDEVELOPMENTSTORCHhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; ArgentinaFil: Schuler-Faccini, Lavínia. Universidade Federal do Rio Grande do Sul; BrasilFil: Garcez, Patricia Pestana. Universidade Federal do Rio de Janeiro; BrasilPublic Library of Science2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96440Barbeito Andrés, Jimena; Schuler Faccini, Lavínia; Garcez, Patricia Pestana; Why is congenital Zika syndrome asymmetrically distributed among human populations?; Public Library of Science; PLoS Biology; 16; 8; 8-2018; 1-111544-9173CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://dx.plos.org/10.1371/journal.pbio.2006592info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pbio.2006592info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:25:15Zoai:ri.conicet.gov.ar:11336/96440instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:25:15.729CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Why is congenital Zika syndrome asymmetrically distributed among human populations?
title Why is congenital Zika syndrome asymmetrically distributed among human populations?
spellingShingle Why is congenital Zika syndrome asymmetrically distributed among human populations?
Barbeito Andrés, Jimena
BRAIN
DEVELOPMENT
STORCH
title_short Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_full Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_fullStr Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_full_unstemmed Why is congenital Zika syndrome asymmetrically distributed among human populations?
title_sort Why is congenital Zika syndrome asymmetrically distributed among human populations?
dc.creator.none.fl_str_mv Barbeito Andrés, Jimena
Schuler Faccini, Lavínia
Garcez, Patricia Pestana
author Barbeito Andrés, Jimena
author_facet Barbeito Andrés, Jimena
Schuler Faccini, Lavínia
Garcez, Patricia Pestana
author_role author
author2 Schuler Faccini, Lavínia
Garcez, Patricia Pestana
author2_role author
author
dc.subject.none.fl_str_mv BRAIN
DEVELOPMENT
STORCH
topic BRAIN
DEVELOPMENT
STORCH
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
Fil: Barbeito Andrés, Jimena. Universidad Nacional Arturo Jauretche. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Unidad Ejecutora de Estudios en Neurociencias y Sistemas Complejos; Argentina
Fil: Schuler-Faccini, Lavínia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Garcez, Patricia Pestana. Universidade Federal do Rio de Janeiro; Brasil
description Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96440
Barbeito Andrés, Jimena; Schuler Faccini, Lavínia; Garcez, Patricia Pestana; Why is congenital Zika syndrome asymmetrically distributed among human populations?; Public Library of Science; PLoS Biology; 16; 8; 8-2018; 1-11
1544-9173
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96440
identifier_str_mv Barbeito Andrés, Jimena; Schuler Faccini, Lavínia; Garcez, Patricia Pestana; Why is congenital Zika syndrome asymmetrically distributed among human populations?; Public Library of Science; PLoS Biology; 16; 8; 8-2018; 1-11
1544-9173
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://dx.plos.org/10.1371/journal.pbio.2006592
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pbio.2006592
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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