Is insulin resistance a disorder of the brain?

Autores
Das, Undurti, N.; Repossi Marquez, Pablo Gaston; Dain, Alejandro; Eynard, Aldo Renato
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.
Fil: Das, Undurti, N.. Jawaharlal Nehru Technological University; India
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Dain, Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
INSULIN RESISTANCE
BRAIN
DIABETES DEVELOPMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/271939
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Is insulin resistance a disorder of the brain?Das, Undurti, N.Repossi Marquez, Pablo GastonDain, AlejandroEynard, Aldo RenatoINSULIN RESISTANCEBRAINDIABETES DEVELOPMENThttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.Fil: Das, Undurti, N.. Jawaharlal Nehru Technological University; IndiaFil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Dain, Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; ArgentinaFil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFrontiers in Bioscience2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/271939Das, Undurti, N.; Repossi Marquez, Pablo Gaston; Dain, Alejandro; Eynard, Aldo Renato; Is insulin resistance a disorder of the brain?; Frontiers in Bioscience; Frontiers in Bioscience; 16; 1; 1-2011; 1-121093-9946CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/FBL/16/1/10.2741/3671info:eu-repo/semantics/altIdentifier/doi/10.2741/3671info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:16:20Zoai:ri.conicet.gov.ar:11336/271939instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:16:20.34CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Is insulin resistance a disorder of the brain?
title Is insulin resistance a disorder of the brain?
spellingShingle Is insulin resistance a disorder of the brain?
Das, Undurti, N.
INSULIN RESISTANCE
BRAIN
DIABETES DEVELOPMENT
title_short Is insulin resistance a disorder of the brain?
title_full Is insulin resistance a disorder of the brain?
title_fullStr Is insulin resistance a disorder of the brain?
title_full_unstemmed Is insulin resistance a disorder of the brain?
title_sort Is insulin resistance a disorder of the brain?
dc.creator.none.fl_str_mv Das, Undurti, N.
Repossi Marquez, Pablo Gaston
Dain, Alejandro
Eynard, Aldo Renato
author Das, Undurti, N.
author_facet Das, Undurti, N.
Repossi Marquez, Pablo Gaston
Dain, Alejandro
Eynard, Aldo Renato
author_role author
author2 Repossi Marquez, Pablo Gaston
Dain, Alejandro
Eynard, Aldo Renato
author2_role author
author
author
dc.subject.none.fl_str_mv INSULIN RESISTANCE
BRAIN
DIABETES DEVELOPMENT
topic INSULIN RESISTANCE
BRAIN
DIABETES DEVELOPMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.
Fil: Das, Undurti, N.. Jawaharlal Nehru Technological University; India
Fil: Repossi Marquez, Pablo Gaston. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Dain, Alejandro. Universidad Nacional de Córdoba. Facultad de Medicina. Instituto de Biología Celular; Argentina
Fil: Eynard, Aldo Renato. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description There is reasonable evidence to suggest that insulin resistance may have its origins in the hypothalamus. Insulin secretion is regulated by sympathetic and parasympathetic nervous systems and modulates the concentrations of hypothalamic neuropeptides and monoaminergic neurotransmitters, and, in return, hypothalamic monoamines regulate the secretion of insulin by pancreatic beta cells. A lesion of the ventromedial hypothalamus produces all the features of the metabolic syndrome including insulin resistance and hyperinsulinemia. These and other evidence suggest that insulin resistance may very well be a disease of the brain.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/271939
Das, Undurti, N.; Repossi Marquez, Pablo Gaston; Dain, Alejandro; Eynard, Aldo Renato; Is insulin resistance a disorder of the brain?; Frontiers in Bioscience; Frontiers in Bioscience; 16; 1; 1-2011; 1-12
1093-9946
CONICET Digital
CONICET
url http://hdl.handle.net/11336/271939
identifier_str_mv Das, Undurti, N.; Repossi Marquez, Pablo Gaston; Dain, Alejandro; Eynard, Aldo Renato; Is insulin resistance a disorder of the brain?; Frontiers in Bioscience; Frontiers in Bioscience; 16; 1; 1-2011; 1-12
1093-9946
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.imrpress.com/journal/FBL/16/1/10.2741/3671
info:eu-repo/semantics/altIdentifier/doi/10.2741/3671
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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