Flow injection biamperometric determination of captopril

Autores
Palomeque, Miriam Edid; Fernández Band, Beatriz Susana
Año de publicación
2002
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 μg ml-1 of captopril. The relative standard deviation for the determination of 0.76 μg ml-1 of captopril is 0.97% (n=12) and the sample throughput is 69 h-1. This method was applied to the determination of captopril to commercially available pharmaceutical preparations.
Fil: Palomeque, Miriam Edid. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina
Materia
BIAMPEROMETRY
CAPTOPRIL
FLOW INJECTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96897
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Flow injection biamperometric determination of captoprilPalomeque, Miriam EdidFernández Band, Beatriz SusanaBIAMPEROMETRYCAPTOPRILFLOW INJECTIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 μg ml-1 of captopril. The relative standard deviation for the determination of 0.76 μg ml-1 of captopril is 0.97% (n=12) and the sample throughput is 69 h-1. This method was applied to the determination of captopril to commercially available pharmaceutical preparations.Fil: Palomeque, Miriam Edid. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; ArgentinaFil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química. Química Analitica; ArgentinaElsevier Science2002-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96897Palomeque, Miriam Edid; Fernández Band, Beatriz Susana; Flow injection biamperometric determination of captopril; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 30; 3; 9-2002; 547-5520731-7085CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0731-7085(02)00315-1info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0731708502003151info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:17Zoai:ri.conicet.gov.ar:11336/96897instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:17.305CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Flow injection biamperometric determination of captopril
title Flow injection biamperometric determination of captopril
spellingShingle Flow injection biamperometric determination of captopril
Palomeque, Miriam Edid
BIAMPEROMETRY
CAPTOPRIL
FLOW INJECTION
title_short Flow injection biamperometric determination of captopril
title_full Flow injection biamperometric determination of captopril
title_fullStr Flow injection biamperometric determination of captopril
title_full_unstemmed Flow injection biamperometric determination of captopril
title_sort Flow injection biamperometric determination of captopril
dc.creator.none.fl_str_mv Palomeque, Miriam Edid
Fernández Band, Beatriz Susana
author Palomeque, Miriam Edid
author_facet Palomeque, Miriam Edid
Fernández Band, Beatriz Susana
author_role author
author2 Fernández Band, Beatriz Susana
author2_role author
dc.subject.none.fl_str_mv BIAMPEROMETRY
CAPTOPRIL
FLOW INJECTION
topic BIAMPEROMETRY
CAPTOPRIL
FLOW INJECTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 μg ml-1 of captopril. The relative standard deviation for the determination of 0.76 μg ml-1 of captopril is 0.97% (n=12) and the sample throughput is 69 h-1. This method was applied to the determination of captopril to commercially available pharmaceutical preparations.
Fil: Palomeque, Miriam Edid. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina
Fil: Fernández Band, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Instituto de Química del Sur. Universidad Nacional del Sur. Departamento de Química. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur. Departamento de Química. Química Analitica; Argentina
description An automated method to determine captopril (1-[(2S)-3-mercapto-2-methylpropionyl]-L-proline) is proposed. A flow injection manifold based on the indirect biamperometric detection of the captopril by using Fe(III)/Fe(II) as an indicating redox system and a Z-shaped flow-cell configuration, was developed. The calibration curve is linear over the range 0.03-3.6 μg ml-1 of captopril. The relative standard deviation for the determination of 0.76 μg ml-1 of captopril is 0.97% (n=12) and the sample throughput is 69 h-1. This method was applied to the determination of captopril to commercially available pharmaceutical preparations.
publishDate 2002
dc.date.none.fl_str_mv 2002-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96897
Palomeque, Miriam Edid; Fernández Band, Beatriz Susana; Flow injection biamperometric determination of captopril; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 30; 3; 9-2002; 547-552
0731-7085
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96897
identifier_str_mv Palomeque, Miriam Edid; Fernández Band, Beatriz Susana; Flow injection biamperometric determination of captopril; Elsevier Science; Journal of Pharmaceutical and Biomedical Analysis; 30; 3; 9-2002; 547-552
0731-7085
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/S0731-7085(02)00315-1
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0731708502003151
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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