Modulation of monocrotaline-induced cor pulmonale by grape juice

Autores
Ludke, Ana R L; Mosele, Francisca; Caron-Lienert, Rafaela; Ribeiro, Maria Flávia; Partata, W?nia; Llesuy, Susana Francisca; Araujo, Alex Sander; Singal, Pawan; Belló-Klein, Adriane
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes. Copyright © 2010 by Lippincott Williams & Wilkins.
Fil: Ludke, Ana R L. University of Manitoba; Canadá
Fil: Mosele, Francisca. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Caron-Lienert, Rafaela. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Ribeiro, Maria Flávia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Partata, W?nia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina
Fil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Singal, Pawan. University of Manitoba; Canadá
Fil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Materia
Cor Pulmonale
Grape Juice
Monocrotaline
Nitric Oxide
Oxidative Stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67631
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/67631
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of monocrotaline-induced cor pulmonale by grape juiceLudke, Ana R LMosele, FranciscaCaron-Lienert, RafaelaRibeiro, Maria FláviaPartata, W?niaLlesuy, Susana FranciscaAraujo, Alex SanderSingal, PawanBelló-Klein, AdrianeCor PulmonaleGrape JuiceMonocrotalineNitric OxideOxidative Stresshttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes. Copyright © 2010 by Lippincott Williams & Wilkins.Fil: Ludke, Ana R L. University of Manitoba; CanadáFil: Mosele, Francisca. Universidade Federal do Rio Grande do Sul; BrasilFil: Caron-Lienert, Rafaela. Universidade Federal do Rio Grande do Sul; BrasilFil: Ribeiro, Maria Flávia. Universidade Federal do Rio Grande do Sul; BrasilFil: Partata, W?nia. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; ArgentinaFil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; BrasilFil: Singal, Pawan. University of Manitoba; CanadáFil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilLippincott Williams2010-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67631Ludke, Ana R L; Mosele, Francisca; Caron-Lienert, Rafaela; Ribeiro, Maria Flávia; Partata, W?nia; et al.; Modulation of monocrotaline-induced cor pulmonale by grape juice; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 1; 1-2010; 89-950160-2446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0b013e3181c87a9dinfo:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00005344-201001000-00014info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:53:30Zoai:ri.conicet.gov.ar:11336/67631instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:53:30.752CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of monocrotaline-induced cor pulmonale by grape juice
title Modulation of monocrotaline-induced cor pulmonale by grape juice
spellingShingle Modulation of monocrotaline-induced cor pulmonale by grape juice
Ludke, Ana R L
Cor Pulmonale
Grape Juice
Monocrotaline
Nitric Oxide
Oxidative Stress
title_short Modulation of monocrotaline-induced cor pulmonale by grape juice
title_full Modulation of monocrotaline-induced cor pulmonale by grape juice
title_fullStr Modulation of monocrotaline-induced cor pulmonale by grape juice
title_full_unstemmed Modulation of monocrotaline-induced cor pulmonale by grape juice
title_sort Modulation of monocrotaline-induced cor pulmonale by grape juice
dc.creator.none.fl_str_mv Ludke, Ana R L
Mosele, Francisca
Caron-Lienert, Rafaela
Ribeiro, Maria Flávia
Partata, W?nia
Llesuy, Susana Francisca
Araujo, Alex Sander
Singal, Pawan
Belló-Klein, Adriane
author Ludke, Ana R L
author_facet Ludke, Ana R L
Mosele, Francisca
Caron-Lienert, Rafaela
Ribeiro, Maria Flávia
Partata, W?nia
Llesuy, Susana Francisca
Araujo, Alex Sander
Singal, Pawan
Belló-Klein, Adriane
author_role author
author2 Mosele, Francisca
Caron-Lienert, Rafaela
Ribeiro, Maria Flávia
Partata, W?nia
Llesuy, Susana Francisca
Araujo, Alex Sander
Singal, Pawan
Belló-Klein, Adriane
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cor Pulmonale
Grape Juice
Monocrotaline
Nitric Oxide
Oxidative Stress
topic Cor Pulmonale
Grape Juice
Monocrotaline
Nitric Oxide
Oxidative Stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes. Copyright © 2010 by Lippincott Williams & Wilkins.
Fil: Ludke, Ana R L. University of Manitoba; Canadá
Fil: Mosele, Francisca. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Caron-Lienert, Rafaela. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Ribeiro, Maria Flávia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Partata, W?nia. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Programa de Radicales Libres; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica; Argentina
Fil: Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Singal, Pawan. University of Manitoba; Canadá
Fil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
description The study was designed to test whether the ingestion grape juice (GJ) could modulate monocrotaline (MCT)-induced Cor pulmonale resulting from antioxidant properties. Three-week-old male Wistar rats received GJ (10 mL/kg/day) by gavage for 6 weeks. A single injection of MCT (60 mg/kg body weight intraperitoneally) was administered at the end of the third week. Animals were divided in four groups: control, MCT, GJ, and GJ + MCT. MCT promoted a significant increase in right ventricle (36%) and lung (70%) weight to body weight ratio. There was an increase in the right systolic (38%) as well as in the end diastolic (70%) ventricular pressures. MCT caused a significant decrease in lung endothelial nitric oxide synthase (20%) but increase in lipid peroxidation (13%) and catalase (43%). MCT-induced decrease in the endothelial nitric oxide synthase and increase in the right ventricular end diastolic pressure were prevented by GJ, whereas right systolic ventricular pressure and lung weight to body weight ratio were corrected only partially. MCT-induced increase in heart and right ventricle to body weight ratios was not changed by GJ. GJ blunted MCT-induced increase in lipid peroxidation but had no effect on the changes in catalase and superoxide dismutase activities. GJ appears to offer some protection against MCT-induced Cor pulmonale and right ventricle function changes. Copyright © 2010 by Lippincott Williams & Wilkins.
publishDate 2010
dc.date.none.fl_str_mv 2010-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67631
Ludke, Ana R L; Mosele, Francisca; Caron-Lienert, Rafaela; Ribeiro, Maria Flávia; Partata, W?nia; et al.; Modulation of monocrotaline-induced cor pulmonale by grape juice; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 1; 1-2010; 89-95
0160-2446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67631
identifier_str_mv Ludke, Ana R L; Mosele, Francisca; Caron-Lienert, Rafaela; Ribeiro, Maria Flávia; Partata, W?nia; et al.; Modulation of monocrotaline-induced cor pulmonale by grape juice; Lippincott Williams; Journal Of Cardiovascular Pharmacology; 55; 1; 1-2010; 89-95
0160-2446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0b013e3181c87a9d
info:eu-repo/semantics/altIdentifier/url/https://insights.ovid.com/crossref?an=00005344-201001000-00014
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782230906535936
score 12.982451

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