Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats

Autores
Campos Carraro, Cristina; Turck, Patrick; De Lima Seolin, Bruna Gazzi; Tavares, Angela Maria Vicente; Dos Santos Lacerda, Denise; Corssac, Giana Blume; Teixeira, Rayane Brinck; Hickmann, Alexandre; Llesuy, Susana Francisca; Da Rosa Araujo, Alex Sander; Belló-Klein, Adriane
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
There is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (RV) failure caused by pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). In this study, it was evaluated the action of copaiba oil on the modulation of proteins involved in RV apoptosis signaling in rats with PAH. Male Wistar rats (±170 g, n = 7/group) were divided into 4 groups: control, MCT, copaiba oil, and MCT + copaiba oil. PAH was induced by MCT (60 mg/kg intraperitoneally) and, 7 days later, treatment with copaiba oil (400 mg/kg by gavage) was given for 14 days. Echocardiographic and hemodynamic measurements were performed, and the RV was collected for morphometric evaluations, oxidative stress, apoptosis, and cell survival signaling, and eNOS protein expression. Copaiba oil reduced RV hypertrophy (24%), improved RV systolic function, and reduced RV end-diastolic pressure, increased total sulfhydryl levels and eNOS protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the RV of MCT + copaiba oil as compared to MCT group. In conclusion, copaiba oil reduced oxidative stress, and apoptosis signaling in RV of rats with PAH, which may be associated with an improvement in cardiac function caused by this compound.
Fil: Campos Carraro, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Turck, Patrick. Universidade Federal do Rio Grande do Sul; Brasil
Fil: De Lima Seolin, Bruna Gazzi. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Tavares, Angela Maria Vicente. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dos Santos Lacerda, Denise. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Corssac, Giana Blume. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Teixeira, Rayane Brinck. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hickmann, Alexandre. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Da Rosa Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
Materia
APOPTOSIS
COPAIBA OIL
MONOCROTALINE
OXIDATIVE STRESS
PULMONARY ARTERIAL HYPERTENSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/227942
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/227942
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced RatsCampos Carraro, CristinaTurck, PatrickDe Lima Seolin, Bruna GazziTavares, Angela Maria VicenteDos Santos Lacerda, DeniseCorssac, Giana BlumeTeixeira, Rayane BrinckHickmann, AlexandreLlesuy, Susana FranciscaDa Rosa Araujo, Alex SanderBelló-Klein, AdrianeAPOPTOSISCOPAIBA OILMONOCROTALINEOXIDATIVE STRESSPULMONARY ARTERIAL HYPERTENSIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1There is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (RV) failure caused by pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). In this study, it was evaluated the action of copaiba oil on the modulation of proteins involved in RV apoptosis signaling in rats with PAH. Male Wistar rats (±170 g, n = 7/group) were divided into 4 groups: control, MCT, copaiba oil, and MCT + copaiba oil. PAH was induced by MCT (60 mg/kg intraperitoneally) and, 7 days later, treatment with copaiba oil (400 mg/kg by gavage) was given for 14 days. Echocardiographic and hemodynamic measurements were performed, and the RV was collected for morphometric evaluations, oxidative stress, apoptosis, and cell survival signaling, and eNOS protein expression. Copaiba oil reduced RV hypertrophy (24%), improved RV systolic function, and reduced RV end-diastolic pressure, increased total sulfhydryl levels and eNOS protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the RV of MCT + copaiba oil as compared to MCT group. In conclusion, copaiba oil reduced oxidative stress, and apoptosis signaling in RV of rats with PAH, which may be associated with an improvement in cardiac function caused by this compound.Fil: Campos Carraro, Cristina. Universidade Federal do Rio Grande do Sul; BrasilFil: Turck, Patrick. Universidade Federal do Rio Grande do Sul; BrasilFil: De Lima Seolin, Bruna Gazzi. Universidade Federal do Rio Grande do Sul; BrasilFil: Tavares, Angela Maria Vicente. Universidade Federal do Rio Grande do Sul; BrasilFil: Dos Santos Lacerda, Denise. Universidade Federal do Rio Grande do Sul; BrasilFil: Corssac, Giana Blume. Universidade Federal do Rio Grande do Sul; BrasilFil: Teixeira, Rayane Brinck. Universidade Federal do Rio Grande do Sul; BrasilFil: Hickmann, Alexandre. Universidade Federal do Rio Grande do Sul; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Da Rosa Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; BrasilFil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; BrasilLippincott Williams2018-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/227942Campos Carraro, Cristina; Turck, Patrick; De Lima Seolin, Bruna Gazzi; Tavares, Angela Maria Vicente; Dos Santos Lacerda, Denise; et al.; Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats; Lippincott Williams; Journal of Cardiovascular Pharmacology; 72; 5; 11-2018; 214-2210160-2446CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/cardiovascularpharm/abstract/2018/11000/copaiba_oil_attenuates_right_ventricular.2.aspxinfo:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0000000000000617info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-01-14T12:10:02Zoai:ri.conicet.gov.ar:11336/227942instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-01-14 12:10:02.391CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
title Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
spellingShingle Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
Campos Carraro, Cristina
APOPTOSIS
COPAIBA OIL
MONOCROTALINE
OXIDATIVE STRESS
PULMONARY ARTERIAL HYPERTENSION
title_short Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
title_full Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
title_fullStr Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
title_full_unstemmed Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
title_sort Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats
dc.creator.none.fl_str_mv Campos Carraro, Cristina
Turck, Patrick
De Lima Seolin, Bruna Gazzi
Tavares, Angela Maria Vicente
Dos Santos Lacerda, Denise
Corssac, Giana Blume
Teixeira, Rayane Brinck
Hickmann, Alexandre
Llesuy, Susana Francisca
Da Rosa Araujo, Alex Sander
Belló-Klein, Adriane
author Campos Carraro, Cristina
author_facet Campos Carraro, Cristina
Turck, Patrick
De Lima Seolin, Bruna Gazzi
Tavares, Angela Maria Vicente
Dos Santos Lacerda, Denise
Corssac, Giana Blume
Teixeira, Rayane Brinck
Hickmann, Alexandre
Llesuy, Susana Francisca
Da Rosa Araujo, Alex Sander
Belló-Klein, Adriane
author_role author
author2 Turck, Patrick
De Lima Seolin, Bruna Gazzi
Tavares, Angela Maria Vicente
Dos Santos Lacerda, Denise
Corssac, Giana Blume
Teixeira, Rayane Brinck
Hickmann, Alexandre
Llesuy, Susana Francisca
Da Rosa Araujo, Alex Sander
Belló-Klein, Adriane
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
COPAIBA OIL
MONOCROTALINE
OXIDATIVE STRESS
PULMONARY ARTERIAL HYPERTENSION
topic APOPTOSIS
COPAIBA OIL
MONOCROTALINE
OXIDATIVE STRESS
PULMONARY ARTERIAL HYPERTENSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv There is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (RV) failure caused by pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). In this study, it was evaluated the action of copaiba oil on the modulation of proteins involved in RV apoptosis signaling in rats with PAH. Male Wistar rats (±170 g, n = 7/group) were divided into 4 groups: control, MCT, copaiba oil, and MCT + copaiba oil. PAH was induced by MCT (60 mg/kg intraperitoneally) and, 7 days later, treatment with copaiba oil (400 mg/kg by gavage) was given for 14 days. Echocardiographic and hemodynamic measurements were performed, and the RV was collected for morphometric evaluations, oxidative stress, apoptosis, and cell survival signaling, and eNOS protein expression. Copaiba oil reduced RV hypertrophy (24%), improved RV systolic function, and reduced RV end-diastolic pressure, increased total sulfhydryl levels and eNOS protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the RV of MCT + copaiba oil as compared to MCT group. In conclusion, copaiba oil reduced oxidative stress, and apoptosis signaling in RV of rats with PAH, which may be associated with an improvement in cardiac function caused by this compound.
Fil: Campos Carraro, Cristina. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Turck, Patrick. Universidade Federal do Rio Grande do Sul; Brasil
Fil: De Lima Seolin, Bruna Gazzi. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Tavares, Angela Maria Vicente. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Dos Santos Lacerda, Denise. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Corssac, Giana Blume. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Teixeira, Rayane Brinck. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Hickmann, Alexandre. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Da Rosa Araujo, Alex Sander. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Belló-Klein, Adriane. Universidade Federal do Rio Grande do Sul; Brasil
description There is an increase in oxidative stress and apoptosis signaling during the transition from hypertrophy to right ventricular (RV) failure caused by pulmonary arterial hypertension (PAH) induced by monocrotaline (MCT). In this study, it was evaluated the action of copaiba oil on the modulation of proteins involved in RV apoptosis signaling in rats with PAH. Male Wistar rats (±170 g, n = 7/group) were divided into 4 groups: control, MCT, copaiba oil, and MCT + copaiba oil. PAH was induced by MCT (60 mg/kg intraperitoneally) and, 7 days later, treatment with copaiba oil (400 mg/kg by gavage) was given for 14 days. Echocardiographic and hemodynamic measurements were performed, and the RV was collected for morphometric evaluations, oxidative stress, apoptosis, and cell survival signaling, and eNOS protein expression. Copaiba oil reduced RV hypertrophy (24%), improved RV systolic function, and reduced RV end-diastolic pressure, increased total sulfhydryl levels and eNOS protein expression, reduced lipid and protein oxidation, and the expression of proteins involved in apoptosis signaling in the RV of MCT + copaiba oil as compared to MCT group. In conclusion, copaiba oil reduced oxidative stress, and apoptosis signaling in RV of rats with PAH, which may be associated with an improvement in cardiac function caused by this compound.
publishDate 2018
dc.date.none.fl_str_mv 2018-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/227942
Campos Carraro, Cristina; Turck, Patrick; De Lima Seolin, Bruna Gazzi; Tavares, Angela Maria Vicente; Dos Santos Lacerda, Denise; et al.; Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats; Lippincott Williams; Journal of Cardiovascular Pharmacology; 72; 5; 11-2018; 214-221
0160-2446
CONICET Digital
CONICET
url http://hdl.handle.net/11336/227942
identifier_str_mv Campos Carraro, Cristina; Turck, Patrick; De Lima Seolin, Bruna Gazzi; Tavares, Angela Maria Vicente; Dos Santos Lacerda, Denise; et al.; Copaiba Oil Attenuates Right Ventricular Remodeling by Decreasing Myocardial Apoptotic Signaling in Monocrotaline-Induced Rats; Lippincott Williams; Journal of Cardiovascular Pharmacology; 72; 5; 11-2018; 214-221
0160-2446
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://journals.lww.com/cardiovascularpharm/abstract/2018/11000/copaiba_oil_attenuates_right_ventricular.2.aspx
info:eu-repo/semantics/altIdentifier/doi/10.1097/FJC.0000000000000617
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.071171

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