Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system

Autores
Graafen, Dirk; Franzoni, Maria Belen; Schreiber, Laura M.; Spiess, Hans W.; Münnemann, Kerstin
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future.
Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania
Fil: Franzoni, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Max Planck Institute for Polymer Research; Alemania
Fil: Schreiber, Laura M.. Johannes Gutenberg University Medical Center; Alemania
Fil: Spiess, Hans W.. Max Planck Institute for Polymer Research; Alemania
Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Alemania
Materia
Hyperpolarization
Long Lived State
Parahydrogen
Phip
Pulse Sequence
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/71957
Acceder
id CONICETDig_954740a242280e90a799c84fa2c6a8cf
oai_identifier_str oai:ri.conicet.gov.ar:11336/71957
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical systemGraafen, DirkFranzoni, Maria BelenSchreiber, Laura M.Spiess, Hans W.Münnemann, KerstinHyperpolarizationLong Lived StateParahydrogenPhipPulse Sequencehttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future.Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; AlemaniaFil: Franzoni, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Max Planck Institute for Polymer Research; AlemaniaFil: Schreiber, Laura M.. Johannes Gutenberg University Medical Center; AlemaniaFil: Spiess, Hans W.. Max Planck Institute for Polymer Research; AlemaniaFil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; AlemaniaAcademic Press Inc Elsevier Science2016-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/71957Graafen, Dirk; Franzoni, Maria Belen; Schreiber, Laura M.; Spiess, Hans W.; Münnemann, Kerstin; Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 262; 1-2016; 68-721090-7807CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmr.2015.12.006info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090780715003043info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:48Zoai:ri.conicet.gov.ar:11336/71957instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:48:48.997CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
title Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
spellingShingle Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
Graafen, Dirk
Hyperpolarization
Long Lived State
Parahydrogen
Phip
Pulse Sequence
title_short Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
title_full Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
title_fullStr Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
title_full_unstemmed Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
title_sort Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system
dc.creator.none.fl_str_mv Graafen, Dirk
Franzoni, Maria Belen
Schreiber, Laura M.
Spiess, Hans W.
Münnemann, Kerstin
author Graafen, Dirk
author_facet Graafen, Dirk
Franzoni, Maria Belen
Schreiber, Laura M.
Spiess, Hans W.
Münnemann, Kerstin
author_role author
author2 Franzoni, Maria Belen
Schreiber, Laura M.
Spiess, Hans W.
Münnemann, Kerstin
author2_role author
author
author
author
dc.subject.none.fl_str_mv Hyperpolarization
Long Lived State
Parahydrogen
Phip
Pulse Sequence
topic Hyperpolarization
Long Lived State
Parahydrogen
Phip
Pulse Sequence
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future.
Fil: Graafen, Dirk. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania
Fil: Franzoni, Maria Belen. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Max Planck Institute for Polymer Research; Alemania
Fil: Schreiber, Laura M.. Johannes Gutenberg University Medical Center; Alemania
Fil: Spiess, Hans W.. Max Planck Institute for Polymer Research; Alemania
Fil: Münnemann, Kerstin. Max Planck Institute for Polymer Research; Alemania
description Hyperpolarization is a powerful tool to overcome the low sensitivity of nuclear magnetic resonance (NMR). However, applications are limited due to the short lifetime of this non equilibrium spin state caused by relaxation processes. This issue can be addressed by storing hyperpolarization in slowly decaying singlet spin states which was so far mostly demonstrated for non-proton spin pairs, e.g. 13C-13C. Protons hyperpolarized by parahydrogen induced polarization (PHIP) in symmetrical molecules, are very well suited for this strategy because they naturally exhibit a long-lived singlet state. The conversion of the NMR silent singlet spin state to observable magnetization can be achieved by making use of singlet-triplet level anticrossings. In this study, a low-power radiofrequency pulse sequence is used for this purpose, which allows multiple successive singlet-triplet conversions. The generated magnetization is used to record proton images in a clinical magnetic resonance imaging (MRI) system, after 3 min waiting time. Our results may open unprecedented opportunities to use the standard MRI nucleus 1H for e.g. metabolic imaging in the future.
publishDate 2016
dc.date.none.fl_str_mv 2016-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/71957
Graafen, Dirk; Franzoni, Maria Belen; Schreiber, Laura M.; Spiess, Hans W.; Münnemann, Kerstin; Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 262; 1-2016; 68-72
1090-7807
CONICET Digital
CONICET
url http://hdl.handle.net/11336/71957
identifier_str_mv Graafen, Dirk; Franzoni, Maria Belen; Schreiber, Laura M.; Spiess, Hans W.; Münnemann, Kerstin; Magnetic resonance imaging of 1H long lived states derived from parahydrogen induced polarization in a clinical system; Academic Press Inc Elsevier Science; Journal Of Magnetic Resonance; 262; 1-2016; 68-72
1090-7807
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmr.2015.12.006
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1090780715003043
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Academic Press Inc Elsevier Science
publisher.none.fl_str_mv Academic Press Inc Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268941144031232
score 13.13397

Publicaciones similares