Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation

Autores
Franzoni, Maria Belen; Graafen, D.; Buljubasich Gentiletti, Lisandro; Schreiber, L. M.; Spiess, H. W.; Münnemann, K.
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hyperpolarization has found many applications in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, its usage is still limited to the observation of relatively fast processes because of its short lifetimes. This issue can be circumvented by storing the hyperpolarization in a slowly relaxing singlet state. Symmetrical molecules hyperpolarized by Parahydrogen Induced Hyperpolarization (PHIP) provide a straightforward access to hyperpolarized singlet states because the initial parahydrogen singlet state is preserved at almost any magnetic field strength. In these systems, which show a remarkably long 1H singlet state lifetime of several minutes, the conversion of the NMR silent singlet state to observable magnetization is feasible due to the existence of singlet-triplet level anti-crossings. Here, we demonstrate that scaling the chemical shift Hamiltonian by rf irradiation is sufficient to transform the singlet into an observable triplet state. Moreover, because the application of one long rf pulse is only partially converting the singlet state, we developed a multiconversion sequence consisting of a train of long rf pulses resulting in successive singlet to triplet conversions. This sequence is used to measure the singlet state relaxation time in a simple way at two different magnetic fields. We show that this approach is valid for almost any magnetic field strength and can be performed even in the less homogeneous field of an MRI scanner, allowing for new applications of hyperpolarized NMR and MRI.
Fil: Franzoni, Maria Belen. Max Planck Institute for Polymer Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Graafen, D.. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania
Fil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Schreiber, L. M.. Johannes Gutenberg University Medical Center; Alemania
Fil: Spiess, H. W.. Max Planck Institute for Polymer Research; Alemania
Fil: Münnemann, K.. Max Planck Institute for Polymer Research; Alemania
Materia
Long Lived States
Hyperpolarization
Parahydrogen
Phip
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/26032
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiationFranzoni, Maria BelenGraafen, D.Buljubasich Gentiletti, LisandroSchreiber, L. M.Spiess, H. W.Münnemann, K.Long Lived StatesHyperpolarizationParahydrogenPhiphttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Hyperpolarization has found many applications in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, its usage is still limited to the observation of relatively fast processes because of its short lifetimes. This issue can be circumvented by storing the hyperpolarization in a slowly relaxing singlet state. Symmetrical molecules hyperpolarized by Parahydrogen Induced Hyperpolarization (PHIP) provide a straightforward access to hyperpolarized singlet states because the initial parahydrogen singlet state is preserved at almost any magnetic field strength. In these systems, which show a remarkably long 1H singlet state lifetime of several minutes, the conversion of the NMR silent singlet state to observable magnetization is feasible due to the existence of singlet-triplet level anti-crossings. Here, we demonstrate that scaling the chemical shift Hamiltonian by rf irradiation is sufficient to transform the singlet into an observable triplet state. Moreover, because the application of one long rf pulse is only partially converting the singlet state, we developed a multiconversion sequence consisting of a train of long rf pulses resulting in successive singlet to triplet conversions. This sequence is used to measure the singlet state relaxation time in a simple way at two different magnetic fields. We show that this approach is valid for almost any magnetic field strength and can be performed even in the less homogeneous field of an MRI scanner, allowing for new applications of hyperpolarized NMR and MRI.Fil: Franzoni, Maria Belen. Max Planck Institute for Polymer Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Graafen, D.. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; AlemaniaFil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; ArgentinaFil: Schreiber, L. M.. Johannes Gutenberg University Medical Center; AlemaniaFil: Spiess, H. W.. Max Planck Institute for Polymer Research; AlemaniaFil: Münnemann, K.. Max Planck Institute for Polymer Research; AlemaniaRoyal Society of Chemistry2013-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/26032Franzoni, Maria Belen; Graafen, D.; Buljubasich Gentiletti, Lisandro; Schreiber, L. M.; Spiess, H. W.; et al.; Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation; Royal Society of Chemistry; Physical Chemistry Chemical Physics; 15; 40; 9-2013; 17233-172391463-9076CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/C3CP52029Cinfo:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/-/content/articlelanding/2013/cp/c3cp52029c/unauth#!divAbstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:43:55Zoai:ri.conicet.gov.ar:11336/26032instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:43:55.652CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
title Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
spellingShingle Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
Franzoni, Maria Belen
Long Lived States
Hyperpolarization
Parahydrogen
Phip
title_short Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
title_full Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
title_fullStr Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
title_full_unstemmed Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
title_sort Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation
dc.creator.none.fl_str_mv Franzoni, Maria Belen
Graafen, D.
Buljubasich Gentiletti, Lisandro
Schreiber, L. M.
Spiess, H. W.
Münnemann, K.
author Franzoni, Maria Belen
author_facet Franzoni, Maria Belen
Graafen, D.
Buljubasich Gentiletti, Lisandro
Schreiber, L. M.
Spiess, H. W.
Münnemann, K.
author_role author
author2 Graafen, D.
Buljubasich Gentiletti, Lisandro
Schreiber, L. M.
Spiess, H. W.
Münnemann, K.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Long Lived States
Hyperpolarization
Parahydrogen
Phip
topic Long Lived States
Hyperpolarization
Parahydrogen
Phip
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Hyperpolarization has found many applications in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, its usage is still limited to the observation of relatively fast processes because of its short lifetimes. This issue can be circumvented by storing the hyperpolarization in a slowly relaxing singlet state. Symmetrical molecules hyperpolarized by Parahydrogen Induced Hyperpolarization (PHIP) provide a straightforward access to hyperpolarized singlet states because the initial parahydrogen singlet state is preserved at almost any magnetic field strength. In these systems, which show a remarkably long 1H singlet state lifetime of several minutes, the conversion of the NMR silent singlet state to observable magnetization is feasible due to the existence of singlet-triplet level anti-crossings. Here, we demonstrate that scaling the chemical shift Hamiltonian by rf irradiation is sufficient to transform the singlet into an observable triplet state. Moreover, because the application of one long rf pulse is only partially converting the singlet state, we developed a multiconversion sequence consisting of a train of long rf pulses resulting in successive singlet to triplet conversions. This sequence is used to measure the singlet state relaxation time in a simple way at two different magnetic fields. We show that this approach is valid for almost any magnetic field strength and can be performed even in the less homogeneous field of an MRI scanner, allowing for new applications of hyperpolarized NMR and MRI.
Fil: Franzoni, Maria Belen. Max Planck Institute for Polymer Research; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Graafen, D.. Max Planck Institute for Polymer Research; Alemania. Johannes Gutenberg University Medical Center; Alemania
Fil: Buljubasich Gentiletti, Lisandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Física Enrique Gaviola. Universidad Nacional de Córdoba. Instituto de Física Enrique Gaviola; Argentina
Fil: Schreiber, L. M.. Johannes Gutenberg University Medical Center; Alemania
Fil: Spiess, H. W.. Max Planck Institute for Polymer Research; Alemania
Fil: Münnemann, K.. Max Planck Institute for Polymer Research; Alemania
description Hyperpolarization has found many applications in Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI). However, its usage is still limited to the observation of relatively fast processes because of its short lifetimes. This issue can be circumvented by storing the hyperpolarization in a slowly relaxing singlet state. Symmetrical molecules hyperpolarized by Parahydrogen Induced Hyperpolarization (PHIP) provide a straightforward access to hyperpolarized singlet states because the initial parahydrogen singlet state is preserved at almost any magnetic field strength. In these systems, which show a remarkably long 1H singlet state lifetime of several minutes, the conversion of the NMR silent singlet state to observable magnetization is feasible due to the existence of singlet-triplet level anti-crossings. Here, we demonstrate that scaling the chemical shift Hamiltonian by rf irradiation is sufficient to transform the singlet into an observable triplet state. Moreover, because the application of one long rf pulse is only partially converting the singlet state, we developed a multiconversion sequence consisting of a train of long rf pulses resulting in successive singlet to triplet conversions. This sequence is used to measure the singlet state relaxation time in a simple way at two different magnetic fields. We show that this approach is valid for almost any magnetic field strength and can be performed even in the less homogeneous field of an MRI scanner, allowing for new applications of hyperpolarized NMR and MRI.
publishDate 2013
dc.date.none.fl_str_mv 2013-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/26032
Franzoni, Maria Belen; Graafen, D.; Buljubasich Gentiletti, Lisandro; Schreiber, L. M.; Spiess, H. W.; et al.; Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation; Royal Society of Chemistry; Physical Chemistry Chemical Physics; 15; 40; 9-2013; 17233-17239
1463-9076
CONICET Digital
CONICET
url http://hdl.handle.net/11336/26032
identifier_str_mv Franzoni, Maria Belen; Graafen, D.; Buljubasich Gentiletti, Lisandro; Schreiber, L. M.; Spiess, H. W.; et al.; Hyperpolarized 1H long lived states originating from parahydrogen accessed by rf irradiation; Royal Society of Chemistry; Physical Chemistry Chemical Physics; 15; 40; 9-2013; 17233-17239
1463-9076
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/C3CP52029C
info:eu-repo/semantics/altIdentifier/url/http://pubs.rsc.org/-/content/articlelanding/2013/cp/c3cp52029c/unauth#!divAbstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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