Epidemiology of chronic disease related to arsenic in Argentina: A systematic review

Autores
Bardach, Ariel Esteban; Ciapponi, Agustín; Soto, Natalie; Chaparro, Raul Martin; Calderon, Maria; Briatore, Agustina; Cadoppi, Norma; Tassara, Roberto; Litter, Marta Irene
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Four million people in Argentina are exposed to arsenic contamination from drinking waters of several center-northern provinces. A systematic review to examine the geographical distribution of arsenic-related diseases in Argentina was conducted, searching electronic databases and gray literature up to November 2013. Key informants were also contacted. Of the 430 references identified, 47 (mostly cross-sectional and ecological designs) referred to arsenic concentration in water and its relationship with the incidence and mortality of cancer, dermatological diseases and genetic disorders. A high percentage of the water samples had arsenic concentrations above the WHO threshold value of 10. μg/L, especially in the province of Buenos Aires. The median prevalence of arsenicosis was 2.6% in exposed areas. The proportion of skin cancer in patients with arsenicosis reached 88% in case-series from the Buenos Aires province. We found higher incidence rate ratios per 100. μg/L increment in inorganic arsenic concentration for colorectal, lung, breast, prostate and skin cancer, for both genders. Liver and skin cancer mortality risk ratios were higher in regions with medium/high concentrations than in those with low concentrations. The relative risk of mortality by skin cancer associated to arsenic exposure in the province of Buenos Aires ranged from 2.5 to 5.2. In the north of this province, high levels of arsenic in drinking water were reported; however, removal interventions were scarcely documented. Arsenic contamination in Argentina is associated with an increased risk of serious chronic diseases, including cancer, showing the need for adequate and timely actions.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Chaparro, Raul Martin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Calderon, Maria. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Briatore, Agustina. Hospital Italiano; Argentina
Fil: Cadoppi, Norma. Foro Estratégico para el Desarrollo Nacional; Argentina
Fil: Tassara, Roberto. Foro Estratégico para el Desarrollo Nacional; Argentina
Fil: Litter, Marta Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
Materia
Argentina
Arsenic
Cancer
Epidemiology
Health
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/41759
Acceder
id CONICETDig_94faf0d562bb511f8c665b74903aa877
oai_identifier_str oai:ri.conicet.gov.ar:11336/41759
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Epidemiology of chronic disease related to arsenic in Argentina: A systematic reviewBardach, Ariel EstebanCiapponi, AgustínSoto, NatalieChaparro, Raul MartinCalderon, MariaBriatore, AgustinaCadoppi, NormaTassara, RobertoLitter, Marta IreneArgentinaArsenicCancerEpidemiologyHealthhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Four million people in Argentina are exposed to arsenic contamination from drinking waters of several center-northern provinces. A systematic review to examine the geographical distribution of arsenic-related diseases in Argentina was conducted, searching electronic databases and gray literature up to November 2013. Key informants were also contacted. Of the 430 references identified, 47 (mostly cross-sectional and ecological designs) referred to arsenic concentration in water and its relationship with the incidence and mortality of cancer, dermatological diseases and genetic disorders. A high percentage of the water samples had arsenic concentrations above the WHO threshold value of 10. μg/L, especially in the province of Buenos Aires. The median prevalence of arsenicosis was 2.6% in exposed areas. The proportion of skin cancer in patients with arsenicosis reached 88% in case-series from the Buenos Aires province. We found higher incidence rate ratios per 100. μg/L increment in inorganic arsenic concentration for colorectal, lung, breast, prostate and skin cancer, for both genders. Liver and skin cancer mortality risk ratios were higher in regions with medium/high concentrations than in those with low concentrations. The relative risk of mortality by skin cancer associated to arsenic exposure in the province of Buenos Aires ranged from 2.5 to 5.2. In the north of this province, high levels of arsenic in drinking water were reported; however, removal interventions were scarcely documented. Arsenic contamination in Argentina is associated with an increased risk of serious chronic diseases, including cancer, showing the need for adequate and timely actions.Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Chaparro, Raul Martin. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Calderon, Maria. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Briatore, Agustina. Hospital Italiano; ArgentinaFil: Cadoppi, Norma. Foro Estratégico para el Desarrollo Nacional; ArgentinaFil: Tassara, Roberto. Foro Estratégico para el Desarrollo Nacional; ArgentinaFil: Litter, Marta Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; ArgentinaElsevier Science2015-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/41759Bardach, Ariel Esteban; Ciapponi, Agustín; Soto, Natalie; Chaparro, Raul Martin; Calderon, Maria; et al.; Epidemiology of chronic disease related to arsenic in Argentina: A systematic review; Elsevier Science; 0048-9697; 538; 12-2015; 802-8160048-9697CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.scitotenv.2015.08.070info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0048969715305738info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:41:20Zoai:ri.conicet.gov.ar:11336/41759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:41:21.186CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
title Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
spellingShingle Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
Bardach, Ariel Esteban
Argentina
Arsenic
Cancer
Epidemiology
Health
title_short Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
title_full Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
title_fullStr Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
title_full_unstemmed Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
title_sort Epidemiology of chronic disease related to arsenic in Argentina: A systematic review
dc.creator.none.fl_str_mv Bardach, Ariel Esteban
Ciapponi, Agustín
Soto, Natalie
Chaparro, Raul Martin
Calderon, Maria
Briatore, Agustina
Cadoppi, Norma
Tassara, Roberto
Litter, Marta Irene
author Bardach, Ariel Esteban
author_facet Bardach, Ariel Esteban
Ciapponi, Agustín
Soto, Natalie
Chaparro, Raul Martin
Calderon, Maria
Briatore, Agustina
Cadoppi, Norma
Tassara, Roberto
Litter, Marta Irene
author_role author
author2 Ciapponi, Agustín
Soto, Natalie
Chaparro, Raul Martin
Calderon, Maria
Briatore, Agustina
Cadoppi, Norma
Tassara, Roberto
Litter, Marta Irene
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Argentina
Arsenic
Cancer
Epidemiology
Health
topic Argentina
Arsenic
Cancer
Epidemiology
Health
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Four million people in Argentina are exposed to arsenic contamination from drinking waters of several center-northern provinces. A systematic review to examine the geographical distribution of arsenic-related diseases in Argentina was conducted, searching electronic databases and gray literature up to November 2013. Key informants were also contacted. Of the 430 references identified, 47 (mostly cross-sectional and ecological designs) referred to arsenic concentration in water and its relationship with the incidence and mortality of cancer, dermatological diseases and genetic disorders. A high percentage of the water samples had arsenic concentrations above the WHO threshold value of 10. μg/L, especially in the province of Buenos Aires. The median prevalence of arsenicosis was 2.6% in exposed areas. The proportion of skin cancer in patients with arsenicosis reached 88% in case-series from the Buenos Aires province. We found higher incidence rate ratios per 100. μg/L increment in inorganic arsenic concentration for colorectal, lung, breast, prostate and skin cancer, for both genders. Liver and skin cancer mortality risk ratios were higher in regions with medium/high concentrations than in those with low concentrations. The relative risk of mortality by skin cancer associated to arsenic exposure in the province of Buenos Aires ranged from 2.5 to 5.2. In the north of this province, high levels of arsenic in drinking water were reported; however, removal interventions were scarcely documented. Arsenic contamination in Argentina is associated with an increased risk of serious chronic diseases, including cancer, showing the need for adequate and timely actions.
Fil: Bardach, Ariel Esteban. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Ciapponi, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Soto, Natalie. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Chaparro, Raul Martin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Calderon, Maria. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Briatore, Agustina. Hospital Italiano; Argentina
Fil: Cadoppi, Norma. Foro Estratégico para el Desarrollo Nacional; Argentina
Fil: Tassara, Roberto. Foro Estratégico para el Desarrollo Nacional; Argentina
Fil: Litter, Marta Irene. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica; Argentina
description Four million people in Argentina are exposed to arsenic contamination from drinking waters of several center-northern provinces. A systematic review to examine the geographical distribution of arsenic-related diseases in Argentina was conducted, searching electronic databases and gray literature up to November 2013. Key informants were also contacted. Of the 430 references identified, 47 (mostly cross-sectional and ecological designs) referred to arsenic concentration in water and its relationship with the incidence and mortality of cancer, dermatological diseases and genetic disorders. A high percentage of the water samples had arsenic concentrations above the WHO threshold value of 10. μg/L, especially in the province of Buenos Aires. The median prevalence of arsenicosis was 2.6% in exposed areas. The proportion of skin cancer in patients with arsenicosis reached 88% in case-series from the Buenos Aires province. We found higher incidence rate ratios per 100. μg/L increment in inorganic arsenic concentration for colorectal, lung, breast, prostate and skin cancer, for both genders. Liver and skin cancer mortality risk ratios were higher in regions with medium/high concentrations than in those with low concentrations. The relative risk of mortality by skin cancer associated to arsenic exposure in the province of Buenos Aires ranged from 2.5 to 5.2. In the north of this province, high levels of arsenic in drinking water were reported; however, removal interventions were scarcely documented. Arsenic contamination in Argentina is associated with an increased risk of serious chronic diseases, including cancer, showing the need for adequate and timely actions.
publishDate 2015
dc.date.none.fl_str_mv 2015-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/41759
Bardach, Ariel Esteban; Ciapponi, Agustín; Soto, Natalie; Chaparro, Raul Martin; Calderon, Maria; et al.; Epidemiology of chronic disease related to arsenic in Argentina: A systematic review; Elsevier Science; 0048-9697; 538; 12-2015; 802-816
0048-9697
CONICET Digital
CONICET
url http://hdl.handle.net/11336/41759
identifier_str_mv Bardach, Ariel Esteban; Ciapponi, Agustín; Soto, Natalie; Chaparro, Raul Martin; Calderon, Maria; et al.; Epidemiology of chronic disease related to arsenic in Argentina: A systematic review; Elsevier Science; 0048-9697; 538; 12-2015; 802-816
0048-9697
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.scitotenv.2015.08.070
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0048969715305738
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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