Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome

Autores
Gomez Rosso, Leonardo Adrián; Benítez, María Belén; Fornari, María Cecilia; Berardi, Vanina; Lynch, Santiago; Schreier, Laura Ester; Wikinski, Regina; Cuniberti, Luis Alberto; Brites, Fernando Daniel
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective of the present study was to determine whether leukocitary and soluble cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Cell adhesion molecules, mainly of leukocitary location, have been not previously evaluated in specifically designed cross-sectional studies involving male patients with metabolic syndrome. Moreover, other circulating markers of different candidate atherogenic risk parameters were also studied and the potential existence of a progressive relation between the number of metabolic syndrome components and the above mentioned biomarkers was analyzed. Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male control subjects were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors. Patients with metabolic syndrome showed (a) hypoadiponectinemia (4551 ± 2302 ng/ml vs. 5865 ± 2548 ng/ml, respectively; p < 0.05), (b) an atherogenic lipid and lipoprotein profile, (c) altered HDL chemical composition accompanied by higher cholesteryl ester-triglyceride interchange carried out by CETP, (d) diminished Lp-PLA2 activity (6.5 ± 1.9 vs. 7.3 ± 2.2, p < 0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and (e) high soluble (VCAM-1: 17 ± 5 vs. 13 ± 4 ng/ml, respectively; p < 0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52 ± 15 vs. 45 ± 12 arbitrary units, respectively; p < 0.0005; and lymphocyte CD49d: 312 ± 56 vs. 284 ± 64 arbitrary units, respectively; p < 0.05). The increment in leukocyte and soluble cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to type 2 diabetes and atherosclerotic cardiovascular disease.
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Benítez, María Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Fornari, María Cecilia. No especifíca;
Fil: Berardi, Vanina. No especifíca;
Fil: Lynch, Santiago. Universidad Favaloro; Argentina
Fil: Schreier, Laura Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad Favaloro; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ADHESION MOLECULES
ADIPONECTIN
ATHEROSCLEROSIS
BIOMARKERS
INFLAMMATION
METABOLIC SYNDROME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/152397
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/152397
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndromeGomez Rosso, Leonardo AdriánBenítez, María BelénFornari, María CeciliaBerardi, VaninaLynch, SantiagoSchreier, Laura EsterWikinski, ReginaCuniberti, Luis AlbertoBrites, Fernando DanielADHESION MOLECULESADIPONECTINATHEROSCLEROSISBIOMARKERSINFLAMMATIONMETABOLIC SYNDROMEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective of the present study was to determine whether leukocitary and soluble cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Cell adhesion molecules, mainly of leukocitary location, have been not previously evaluated in specifically designed cross-sectional studies involving male patients with metabolic syndrome. Moreover, other circulating markers of different candidate atherogenic risk parameters were also studied and the potential existence of a progressive relation between the number of metabolic syndrome components and the above mentioned biomarkers was analyzed. Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male control subjects were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors. Patients with metabolic syndrome showed (a) hypoadiponectinemia (4551 ± 2302 ng/ml vs. 5865 ± 2548 ng/ml, respectively; p < 0.05), (b) an atherogenic lipid and lipoprotein profile, (c) altered HDL chemical composition accompanied by higher cholesteryl ester-triglyceride interchange carried out by CETP, (d) diminished Lp-PLA2 activity (6.5 ± 1.9 vs. 7.3 ± 2.2, p < 0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and (e) high soluble (VCAM-1: 17 ± 5 vs. 13 ± 4 ng/ml, respectively; p < 0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52 ± 15 vs. 45 ± 12 arbitrary units, respectively; p < 0.0005; and lymphocyte CD49d: 312 ± 56 vs. 284 ± 64 arbitrary units, respectively; p < 0.05). The increment in leukocyte and soluble cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to type 2 diabetes and atherosclerotic cardiovascular disease.Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Benítez, María Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Fornari, María Cecilia. No especifíca;Fil: Berardi, Vanina. No especifíca;Fil: Lynch, Santiago. Universidad Favaloro; ArgentinaFil: Schreier, Laura Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; ArgentinaFil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad Favaloro; ArgentinaFil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaElsevier Ireland2008-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/152397Gomez Rosso, Leonardo Adrián; Benítez, María Belén; Fornari, María Cecilia; Berardi, Vanina; Lynch, Santiago; et al.; Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome; Elsevier Ireland; Atherosclerosis; 199; 2; 12-2008; 415-4230021-9150CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(07)00735-6info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2007.11.007info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:39Zoai:ri.conicet.gov.ar:11336/152397instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:39.349CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
title Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
spellingShingle Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
Gomez Rosso, Leonardo Adrián
ADHESION MOLECULES
ADIPONECTIN
ATHEROSCLEROSIS
BIOMARKERS
INFLAMMATION
METABOLIC SYNDROME
title_short Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
title_full Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
title_fullStr Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
title_full_unstemmed Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
title_sort Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome
dc.creator.none.fl_str_mv Gomez Rosso, Leonardo Adrián
Benítez, María Belén
Fornari, María Cecilia
Berardi, Vanina
Lynch, Santiago
Schreier, Laura Ester
Wikinski, Regina
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author Gomez Rosso, Leonardo Adrián
author_facet Gomez Rosso, Leonardo Adrián
Benítez, María Belén
Fornari, María Cecilia
Berardi, Vanina
Lynch, Santiago
Schreier, Laura Ester
Wikinski, Regina
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author_role author
author2 Benítez, María Belén
Fornari, María Cecilia
Berardi, Vanina
Lynch, Santiago
Schreier, Laura Ester
Wikinski, Regina
Cuniberti, Luis Alberto
Brites, Fernando Daniel
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ADHESION MOLECULES
ADIPONECTIN
ATHEROSCLEROSIS
BIOMARKERS
INFLAMMATION
METABOLIC SYNDROME
topic ADHESION MOLECULES
ADIPONECTIN
ATHEROSCLEROSIS
BIOMARKERS
INFLAMMATION
METABOLIC SYNDROME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective of the present study was to determine whether leukocitary and soluble cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Cell adhesion molecules, mainly of leukocitary location, have been not previously evaluated in specifically designed cross-sectional studies involving male patients with metabolic syndrome. Moreover, other circulating markers of different candidate atherogenic risk parameters were also studied and the potential existence of a progressive relation between the number of metabolic syndrome components and the above mentioned biomarkers was analyzed. Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male control subjects were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors. Patients with metabolic syndrome showed (a) hypoadiponectinemia (4551 ± 2302 ng/ml vs. 5865 ± 2548 ng/ml, respectively; p < 0.05), (b) an atherogenic lipid and lipoprotein profile, (c) altered HDL chemical composition accompanied by higher cholesteryl ester-triglyceride interchange carried out by CETP, (d) diminished Lp-PLA2 activity (6.5 ± 1.9 vs. 7.3 ± 2.2, p < 0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and (e) high soluble (VCAM-1: 17 ± 5 vs. 13 ± 4 ng/ml, respectively; p < 0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52 ± 15 vs. 45 ± 12 arbitrary units, respectively; p < 0.0005; and lymphocyte CD49d: 312 ± 56 vs. 284 ± 64 arbitrary units, respectively; p < 0.05). The increment in leukocyte and soluble cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to type 2 diabetes and atherosclerotic cardiovascular disease.
Fil: Gomez Rosso, Leonardo Adrián. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Benítez, María Belén. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Fornari, María Cecilia. No especifíca;
Fil: Berardi, Vanina. No especifíca;
Fil: Lynch, Santiago. Universidad Favaloro; Argentina
Fil: Schreier, Laura Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Wikinski, Regina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina
Fil: Cuniberti, Luis Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad Favaloro; Argentina
Fil: Brites, Fernando Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Bioquímica Clínica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Metabolic syndrome is considered a hyperinsulinemic and inflammatory state closely associated to endothelial dysfunction causing an increased incidence of ischemic cardiovascular events and high mortality. The main objective of the present study was to determine whether leukocitary and soluble cell adhesion molecules were altered in patients with metabolic syndrome in comparison with control subjects. Cell adhesion molecules, mainly of leukocitary location, have been not previously evaluated in specifically designed cross-sectional studies involving male patients with metabolic syndrome. Moreover, other circulating markers of different candidate atherogenic risk parameters were also studied and the potential existence of a progressive relation between the number of metabolic syndrome components and the above mentioned biomarkers was analyzed. Thirty one male patients with metabolic syndrome (ATPIII definition) and 56 male control subjects were studied. We evaluated different markers of insulin resistance, inflammation and atherosclerosis, as well as protective factors. Patients with metabolic syndrome showed (a) hypoadiponectinemia (4551 ± 2302 ng/ml vs. 5865 ± 2548 ng/ml, respectively; p < 0.05), (b) an atherogenic lipid and lipoprotein profile, (c) altered HDL chemical composition accompanied by higher cholesteryl ester-triglyceride interchange carried out by CETP, (d) diminished Lp-PLA2 activity (6.5 ± 1.9 vs. 7.3 ± 2.2, p < 0.05, respectively), antioxidant enzyme related with LDL oxidation, which was positively associated with QUICKI and negatively with VCAM-1 and lymphocyte CD18, and (e) high soluble (VCAM-1: 17 ± 5 vs. 13 ± 4 ng/ml, respectively; p < 0.0005) and leukocyte adhesion molecule expression (monocyte CD54: 52 ± 15 vs. 45 ± 12 arbitrary units, respectively; p < 0.0005; and lymphocyte CD49d: 312 ± 56 vs. 284 ± 64 arbitrary units, respectively; p < 0.05). The increment in leukocyte and soluble cell adhesion molecules, crucial for leukocyte interaction with the endothelium and migration into the artery wall, in combination with the other disorders described above reinforce the presence of a clinical status with high propensity to type 2 diabetes and atherosclerotic cardiovascular disease.
publishDate 2008
dc.date.none.fl_str_mv 2008-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/152397
Gomez Rosso, Leonardo Adrián; Benítez, María Belén; Fornari, María Cecilia; Berardi, Vanina; Lynch, Santiago; et al.; Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome; Elsevier Ireland; Atherosclerosis; 199; 2; 12-2008; 415-423
0021-9150
CONICET Digital
CONICET
url http://hdl.handle.net/11336/152397
identifier_str_mv Gomez Rosso, Leonardo Adrián; Benítez, María Belén; Fornari, María Cecilia; Berardi, Vanina; Lynch, Santiago; et al.; Alterations in cell adhesion molecules and other biomarkers of cardiovascular disease in patients with metabolic syndrome; Elsevier Ireland; Atherosclerosis; 199; 2; 12-2008; 415-423
0021-9150
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(07)00735-6
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.atherosclerosis.2007.11.007
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland
publisher.none.fl_str_mv Elsevier Ireland
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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