Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation

Autores
Garimano, Nicolás Ezequiel; Aguayo Frias, Eliana Taís; Gonzalez Maglio, Daniel Horacio
Año de publicación
2025
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Sunlight profoundly affects skin health when it is exposed. After acute exposure, a robust inflammatory response is initiated locally. Moreover, chronic exposures lead to carcinogenesis and photoaging. Local and systemic immunosuppression is also triggered after skin irradiation, affecting adaptive immune responses. These effects are mainly produced by the ultraviolet radiation contained in sunlight and were extensively described and reviewed. However, using UV filters during sunbathing and outdoor activities may allow visible light (VL) wavelengths and infrared radiation (IRR) to reach skin cells. Additionally, the employment of therapeutic VL and IR-emitting lasers and LED devices is increasing for various skin conditions. This literature review aims to present current knowledge on the effects of VL and IRR modulating the skin and systemic immune system. These modulations impact healthy skin and can modify immune responses to diverse stimuli in various cell types. According to the wavelength and the dose, VL and IRR increase the production of reactive oxygen species and promote faster wound healing. Moreover, they modulate inflammatory mediators, such as several cytokines and prostaglandins. However, skin exposure to VL can also affect adaptive immune responses. The study of VL and IRR effects on immunity would promote new uses for phototherapy and may establish the need for new strategies in photoprotection.
Fil: Garimano, Nicolás Ezequiel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Aguayo Frias, Eliana Taís. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; Argentina
Materia
inflammation
infrared radiation
photobiomodulation
phototherapy
visible light
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/277131
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/277131
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiationGarimano, Nicolás EzequielAguayo Frias, Eliana TaísGonzalez Maglio, Daniel Horacioinflammationinfrared radiationphotobiomodulationphototherapyvisible lighthttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Sunlight profoundly affects skin health when it is exposed. After acute exposure, a robust inflammatory response is initiated locally. Moreover, chronic exposures lead to carcinogenesis and photoaging. Local and systemic immunosuppression is also triggered after skin irradiation, affecting adaptive immune responses. These effects are mainly produced by the ultraviolet radiation contained in sunlight and were extensively described and reviewed. However, using UV filters during sunbathing and outdoor activities may allow visible light (VL) wavelengths and infrared radiation (IRR) to reach skin cells. Additionally, the employment of therapeutic VL and IR-emitting lasers and LED devices is increasing for various skin conditions. This literature review aims to present current knowledge on the effects of VL and IRR modulating the skin and systemic immune system. These modulations impact healthy skin and can modify immune responses to diverse stimuli in various cell types. According to the wavelength and the dose, VL and IRR increase the production of reactive oxygen species and promote faster wound healing. Moreover, they modulate inflammatory mediators, such as several cytokines and prostaglandins. However, skin exposure to VL can also affect adaptive immune responses. The study of VL and IRR effects on immunity would promote new uses for phototherapy and may establish the need for new strategies in photoprotection.Fil: Garimano, Nicolás Ezequiel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; ArgentinaFil: Aguayo Frias, Eliana Taís. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; ArgentinaFil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; ArgentinaWiley Blackwell Publishing, Inc2025-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/277131Garimano, Nicolás Ezequiel; Aguayo Frias, Eliana Taís; Gonzalez Maglio, Daniel Horacio; Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation; Wiley Blackwell Publishing, Inc; Photochemistry and Photobiology; 5-2025; 1-120031-8655CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/php.14117info:eu-repo/semantics/altIdentifier/doi/10.1111/php.14117info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-12-23T14:07:21Zoai:ri.conicet.gov.ar:11336/277131instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-12-23 14:07:21.33CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
title Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
spellingShingle Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
Garimano, Nicolás Ezequiel
inflammation
infrared radiation
photobiomodulation
phototherapy
visible light
title_short Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
title_full Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
title_fullStr Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
title_full_unstemmed Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
title_sort Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation
dc.creator.none.fl_str_mv Garimano, Nicolás Ezequiel
Aguayo Frias, Eliana Taís
Gonzalez Maglio, Daniel Horacio
author Garimano, Nicolás Ezequiel
author_facet Garimano, Nicolás Ezequiel
Aguayo Frias, Eliana Taís
Gonzalez Maglio, Daniel Horacio
author_role author
author2 Aguayo Frias, Eliana Taís
Gonzalez Maglio, Daniel Horacio
author2_role author
author
dc.subject.none.fl_str_mv inflammation
infrared radiation
photobiomodulation
phototherapy
visible light
topic inflammation
infrared radiation
photobiomodulation
phototherapy
visible light
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Sunlight profoundly affects skin health when it is exposed. After acute exposure, a robust inflammatory response is initiated locally. Moreover, chronic exposures lead to carcinogenesis and photoaging. Local and systemic immunosuppression is also triggered after skin irradiation, affecting adaptive immune responses. These effects are mainly produced by the ultraviolet radiation contained in sunlight and were extensively described and reviewed. However, using UV filters during sunbathing and outdoor activities may allow visible light (VL) wavelengths and infrared radiation (IRR) to reach skin cells. Additionally, the employment of therapeutic VL and IR-emitting lasers and LED devices is increasing for various skin conditions. This literature review aims to present current knowledge on the effects of VL and IRR modulating the skin and systemic immune system. These modulations impact healthy skin and can modify immune responses to diverse stimuli in various cell types. According to the wavelength and the dose, VL and IRR increase the production of reactive oxygen species and promote faster wound healing. Moreover, they modulate inflammatory mediators, such as several cytokines and prostaglandins. However, skin exposure to VL can also affect adaptive immune responses. The study of VL and IRR effects on immunity would promote new uses for phototherapy and may establish the need for new strategies in photoprotection.
Fil: Garimano, Nicolás Ezequiel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”. Instituto Nacional de Parasitología "Dr. Mario Fatala Chaben”; Argentina
Fil: Aguayo Frias, Eliana Taís. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina
Fil: Gonzalez Maglio, Daniel Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Estudios de la Inmunidad Humoral Prof. Ricardo A. Margni; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Microbiología, Inmunología y Biotecnología. Cátedra de Inmunología; Argentina
description Sunlight profoundly affects skin health when it is exposed. After acute exposure, a robust inflammatory response is initiated locally. Moreover, chronic exposures lead to carcinogenesis and photoaging. Local and systemic immunosuppression is also triggered after skin irradiation, affecting adaptive immune responses. These effects are mainly produced by the ultraviolet radiation contained in sunlight and were extensively described and reviewed. However, using UV filters during sunbathing and outdoor activities may allow visible light (VL) wavelengths and infrared radiation (IRR) to reach skin cells. Additionally, the employment of therapeutic VL and IR-emitting lasers and LED devices is increasing for various skin conditions. This literature review aims to present current knowledge on the effects of VL and IRR modulating the skin and systemic immune system. These modulations impact healthy skin and can modify immune responses to diverse stimuli in various cell types. According to the wavelength and the dose, VL and IRR increase the production of reactive oxygen species and promote faster wound healing. Moreover, they modulate inflammatory mediators, such as several cytokines and prostaglandins. However, skin exposure to VL can also affect adaptive immune responses. The study of VL and IRR effects on immunity would promote new uses for phototherapy and may establish the need for new strategies in photoprotection.
publishDate 2025
dc.date.none.fl_str_mv 2025-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/277131
Garimano, Nicolás Ezequiel; Aguayo Frias, Eliana Taís; Gonzalez Maglio, Daniel Horacio; Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation; Wiley Blackwell Publishing, Inc; Photochemistry and Photobiology; 5-2025; 1-12
0031-8655
CONICET Digital
CONICET
url http://hdl.handle.net/11336/277131
identifier_str_mv Garimano, Nicolás Ezequiel; Aguayo Frias, Eliana Taís; Gonzalez Maglio, Daniel Horacio; Beyond ultraviolet radiation: Immune system modulation through skin exposure to visible light and infrared radiation; Wiley Blackwell Publishing, Inc; Photochemistry and Photobiology; 5-2025; 1-12
0031-8655
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/php.14117
info:eu-repo/semantics/altIdentifier/doi/10.1111/php.14117
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.952241

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