Gallbladder cancer: South American experience
- Autores
- Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.
Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; Argentina
Fil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; Argentina
Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina - Materia
-
Gallbladder cancer (GBC)
South America
Epidemiology
Genetic abnormalities
Pathogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/24335
Ver los metadatos del registro completo
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Gallbladder cancer: South American experienceArroyo, Gerardo F.Gentile, AlbertoParada, Luis AntonioGallbladder cancer (GBC)South AmericaEpidemiologyGenetic abnormalitiesPathogenesisLarge differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; ArgentinaFil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; ArgentinaFil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaAME Publishing Company2016-10-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24335Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-132304-38652304-3873CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21037/cco.2016.10.01info:eu-repo/semantics/altIdentifier/url/http://cco.amegroups.com/article/view/12264/12692info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:13Zoai:ri.conicet.gov.ar:11336/24335instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:14.149CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Gallbladder cancer: South American experience |
title |
Gallbladder cancer: South American experience |
spellingShingle |
Gallbladder cancer: South American experience Arroyo, Gerardo F. Gallbladder cancer (GBC) South America Epidemiology Genetic abnormalities Pathogenesis |
title_short |
Gallbladder cancer: South American experience |
title_full |
Gallbladder cancer: South American experience |
title_fullStr |
Gallbladder cancer: South American experience |
title_full_unstemmed |
Gallbladder cancer: South American experience |
title_sort |
Gallbladder cancer: South American experience |
dc.creator.none.fl_str_mv |
Arroyo, Gerardo F. Gentile, Alberto Parada, Luis Antonio |
author |
Arroyo, Gerardo F. |
author_facet |
Arroyo, Gerardo F. Gentile, Alberto Parada, Luis Antonio |
author_role |
author |
author2 |
Gentile, Alberto Parada, Luis Antonio |
author2_role |
author author |
dc.subject.none.fl_str_mv |
Gallbladder cancer (GBC) South America Epidemiology Genetic abnormalities Pathogenesis |
topic |
Gallbladder cancer (GBC) South America Epidemiology Genetic abnormalities Pathogenesis |
dc.description.none.fl_txt_mv |
Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease. Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; Argentina Fil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; Argentina Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina |
description |
Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-10-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/24335 Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-13 2304-3865 2304-3873 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/24335 |
identifier_str_mv |
Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-13 2304-3865 2304-3873 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.21037/cco.2016.10.01 info:eu-repo/semantics/altIdentifier/url/http://cco.amegroups.com/article/view/12264/12692 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
AME Publishing Company |
publisher.none.fl_str_mv |
AME Publishing Company |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |