Gallbladder cancer: South American experience

Autores
Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.
Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; Argentina
Fil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; Argentina
Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Materia
Gallbladder cancer (GBC)
South America
Epidemiology
Genetic abnormalities
Pathogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/24335
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Gallbladder cancer: South American experienceArroyo, Gerardo F.Gentile, AlbertoParada, Luis AntonioGallbladder cancer (GBC)South AmericaEpidemiologyGenetic abnormalitiesPathogenesisLarge differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; ArgentinaFil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; ArgentinaFil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaAME Publishing Company2016-10-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/24335Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-132304-38652304-3873CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.21037/cco.2016.10.01info:eu-repo/semantics/altIdentifier/url/http://cco.amegroups.com/article/view/12264/12692info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:04Zoai:ri.conicet.gov.ar:11336/24335instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:05.215CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gallbladder cancer: South American experience
title Gallbladder cancer: South American experience
spellingShingle Gallbladder cancer: South American experience
Arroyo, Gerardo F.
Gallbladder cancer (GBC)
South America
Epidemiology
Genetic abnormalities
Pathogenesis
title_short Gallbladder cancer: South American experience
title_full Gallbladder cancer: South American experience
title_fullStr Gallbladder cancer: South American experience
title_full_unstemmed Gallbladder cancer: South American experience
title_sort Gallbladder cancer: South American experience
dc.creator.none.fl_str_mv Arroyo, Gerardo F.
Gentile, Alberto
Parada, Luis Antonio
author Arroyo, Gerardo F.
author_facet Arroyo, Gerardo F.
Gentile, Alberto
Parada, Luis Antonio
author_role author
author2 Gentile, Alberto
Parada, Luis Antonio
author2_role author
author
dc.subject.none.fl_str_mv Gallbladder cancer (GBC)
South America
Epidemiology
Genetic abnormalities
Pathogenesis
topic Gallbladder cancer (GBC)
South America
Epidemiology
Genetic abnormalities
Pathogenesis
dc.description.none.fl_txt_mv Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.
Fil: Arroyo, Gerardo F.. Intergrupo Latinoamericano de Oncología Gastrointestinal; Argentina
Fil: Gentile, Alberto. Provincia de Salta. Ministerio de Salud Pública; Argentina
Fil: Parada, Luis Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
description Large differences in terms of incidence and mortality due to gallbladder cancer (GBC) have been reported worldwide. Moreover, it seems that GBC has unique characteristics in South America. We surveyed the literature looking for information about the epidemiology, basic and translational research, and clinical trials performed in South America in order to critically analyze the magnitude of this health problem in the region. Compared to other geographic areas, age-standardized mortality rates (ASMR) for GBC in women are very high, particularly in many western areas of South America. Genetic, as well as dietary and environmental factors likely contribute to the pathogenesis of this disease in the area. Compared to other regions the profile of abnormalities of key genes such as KRAS and TP53 in GBC seems to slightly differ in South America, while the clinical behavior appears to be similar with a median overall survival (OS) of 6.5 to 8 months in advanced GBC. In contrast to Europe and USA, prophylactic cholecystectomy is a common practice in western areas of South America. GBC particularly affects women in South America, and represents a significant public health problem. It appears to have peculiarities that pose an urgent need for additional research aimed to discover risk factors, molecular events associated with its development and new treatment options for this lethal disease.
publishDate 2016
dc.date.none.fl_str_mv 2016-10-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/24335
Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-13
2304-3865
2304-3873
CONICET Digital
CONICET
url http://hdl.handle.net/11336/24335
identifier_str_mv Arroyo, Gerardo F.; Gentile, Alberto; Parada, Luis Antonio; Gallbladder cancer: South American experience; AME Publishing Company; Chinese Clinical Oncology; 5; 5; 6-10-2016; 1-13
2304-3865
2304-3873
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.21037/cco.2016.10.01
info:eu-repo/semantics/altIdentifier/url/http://cco.amegroups.com/article/view/12264/12692
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv AME Publishing Company
publisher.none.fl_str_mv AME Publishing Company
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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