Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country
- Autores
- Boekstegers, Felix; Scherer, Dominique; Barahona Ponce, Carol; Marcelain, Katherine; Gárate Calderón, Valentina; Waldenberger, Melanie; Morales, Erik; Rojas, Armando; Munoz, César; Retamales, Javier; de Toro, Gonzalo; Barajas, Olga; Rivera, María Teresa; Cortés, Analía; Loader, Denisse; Saavedra, Javiera; Gutiérrez, Lorena; Ortega, Alejandro; Bertrán, Maria Enriqueta; Bartolotti, Leonardo; Gabler, Fernando; Campos, Mónica; Alvarado, Juan; Moisán, Fabricio; Spencer, Loreto; Nervi, Bruno; Carvajal Hausdorf, Daniel; Losada, Héctor; Almau, Mauricio; Fernández, Plinio; Olloquequi, Jordi; Fuentes Guajardo, Macarena; Gonzalez-Jose, Rolando; Bortolini, Maria Cátira; Acuña Alonzo, Victor; Gallo, Carla; Ruiz-Linares, Andres; Rothhammer, Francisco; Lorenzo Bermejo, Justo
- Año de publicación
- 2023
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Since 2006, Chile has been implementing a gallbladder cancer (GBC) prevention program based on prophylactic cholecystectomy for gallstone patients aged 35 to 49 years. The effectiveness of this prevention program has not yet been comprehensively evaluated. We conducted a retrospective study of 473 Chilean GBC patients and 2137 population-based controls to develop and internally validate three GBC risk prediction models. The Baseline Model accounted for gallstones while adjusting for sex and birth year. Enhanced Model I also included the non-genetic risk factors: body mass index, educational level, Mapuche surnames, number of children and family history of GBC. Enhanced Model II further included Mapuche ancestry and the genotype for rs17209837. Multiple Cox regression was applied to assess the predictive performance, quantified by the area under the precision-recall curve (AUC-PRC) and the number of cholecystectomies needed (NCN) to prevent one case of GBC at age 70 years. The AUC-PRC for the Baseline Model (0.44%, 95%CI 0.42-0.46) increased by 0.22 (95%CI 0.15-0.29) when non-genetic factors were included, and by 0.25 (95%CI 0.20-0.30) when incorporating non-genetic and genetic factors. The overall NCN for Chileans with gallstones (115, 95%CI 104-131) decreased to 92 (95%CI 60-128) for Chileans with a higher risk than the median according to Enhanced Model I, and to 80 (95%CI 59-110) according to Enhanced Model II. In conclusion, age, sex and gallstones are strong risk factors for GBC, but consideration of other non-genetic factors and individual genotype data improves risk prediction and may optimize allocation of financial resources and surgical capacity.
Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Marcelain, Katherine. Universidad de Chile; Chile
Fil: Gárate Calderón, Valentina. Universidad de Chile; Chile
Fil: Waldenberger, Melanie. No especifíca;
Fil: Morales, Erik. Universidad Católica de Maule; Chile
Fil: Rojas, Armando. Universidad Católica de Maule; Chile
Fil: Munoz, César. Universidad Católica de Maule; Chile
Fil: Retamales, Javier. Instituto Nacional del Cáncer; Chile
Fil: de Toro, Gonzalo. Universidad Austral de Chile; Chile
Fil: Barajas, Olga. Universidad de Chile; Chile
Fil: Rivera, María Teresa. Hospital del Salvador; Chile
Fil: Cortés, Analía. Hospital del Salvador; Chile
Fil: Loader, Denisse. Hospital Padre Hurtado; Chile
Fil: Saavedra, Javiera. Hospital Padre Hurtado; Chile
Fil: Gutiérrez, Lorena. Hospital San Juan de Dios; Chile
Fil: Ortega, Alejandro. Hospital Regional; Chile
Fil: Bertrán, Maria Enriqueta. Hospital Base de Valdivia; Chile
Fil: Bartolotti, Leonardo. Hospital Base de Valdivia; Chile
Fil: Gabler, Fernando. Hospital Clínico San Borja Arriarán; Chile
Fil: Campos, Mónica. Hospital Clínico San Borja Arriarán; Chile
Fil: Alvarado, Juan. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile
Fil: Moisán, Fabricio. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile
Fil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile
Fil: Nervi, Bruno. No especifíca;
Fil: Carvajal Hausdorf, Daniel. Universidad del Desarrollo; Chile
Fil: Losada, Héctor. Universidad de La Frontera; Chile
Fil: Almau, Mauricio. Hospital de Rancagua; Chile
Fil: Fernández, Plinio. Hospital de Rancagua; Chile
Fil: Olloquequi, Jordi. Universidad de Barcelona; España
Fil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; Chile
Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Acuña Alonzo, Victor. No especifíca;
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Ruiz-Linares, Andres. Colegio Universitario de Londres; Reino Unido
Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile
Fil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; Alemania - Materia
-
CHOLECYSTECTOMY
GALLBLADDER CANCER
GALLSTONES
NATIVE AMERICAN ANCESTRY
NON-GENETIC AND GENETIC RISK FACTORS
RISK PREDICTION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/214479
Ver los metadatos del registro completo
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Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence countryBoekstegers, FelixScherer, DominiqueBarahona Ponce, CarolMarcelain, KatherineGárate Calderón, ValentinaWaldenberger, MelanieMorales, ErikRojas, ArmandoMunoz, CésarRetamales, Javierde Toro, GonzaloBarajas, OlgaRivera, María TeresaCortés, AnalíaLoader, DenisseSaavedra, JavieraGutiérrez, LorenaOrtega, AlejandroBertrán, Maria EnriquetaBartolotti, LeonardoGabler, FernandoCampos, MónicaAlvarado, JuanMoisán, FabricioSpencer, LoretoNervi, BrunoCarvajal Hausdorf, DanielLosada, HéctorAlmau, MauricioFernández, PlinioOlloquequi, JordiFuentes Guajardo, MacarenaGonzalez-Jose, RolandoBortolini, Maria CátiraAcuña Alonzo, VictorGallo, CarlaRuiz-Linares, AndresRothhammer, FranciscoLorenzo Bermejo, JustoCHOLECYSTECTOMYGALLBLADDER CANCERGALLSTONESNATIVE AMERICAN ANCESTRYNON-GENETIC AND GENETIC RISK FACTORSRISK PREDICTIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Since 2006, Chile has been implementing a gallbladder cancer (GBC) prevention program based on prophylactic cholecystectomy for gallstone patients aged 35 to 49 years. The effectiveness of this prevention program has not yet been comprehensively evaluated. We conducted a retrospective study of 473 Chilean GBC patients and 2137 population-based controls to develop and internally validate three GBC risk prediction models. The Baseline Model accounted for gallstones while adjusting for sex and birth year. Enhanced Model I also included the non-genetic risk factors: body mass index, educational level, Mapuche surnames, number of children and family history of GBC. Enhanced Model II further included Mapuche ancestry and the genotype for rs17209837. Multiple Cox regression was applied to assess the predictive performance, quantified by the area under the precision-recall curve (AUC-PRC) and the number of cholecystectomies needed (NCN) to prevent one case of GBC at age 70 years. The AUC-PRC for the Baseline Model (0.44%, 95%CI 0.42-0.46) increased by 0.22 (95%CI 0.15-0.29) when non-genetic factors were included, and by 0.25 (95%CI 0.20-0.30) when incorporating non-genetic and genetic factors. The overall NCN for Chileans with gallstones (115, 95%CI 104-131) decreased to 92 (95%CI 60-128) for Chileans with a higher risk than the median according to Enhanced Model I, and to 80 (95%CI 59-110) according to Enhanced Model II. In conclusion, age, sex and gallstones are strong risk factors for GBC, but consideration of other non-genetic factors and individual genotype data improves risk prediction and may optimize allocation of financial resources and surgical capacity.Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Marcelain, Katherine. Universidad de Chile; ChileFil: Gárate Calderón, Valentina. Universidad de Chile; ChileFil: Waldenberger, Melanie. No especifíca;Fil: Morales, Erik. Universidad Católica de Maule; ChileFil: Rojas, Armando. Universidad Católica de Maule; ChileFil: Munoz, César. Universidad Católica de Maule; ChileFil: Retamales, Javier. Instituto Nacional del Cáncer; ChileFil: de Toro, Gonzalo. Universidad Austral de Chile; ChileFil: Barajas, Olga. Universidad de Chile; ChileFil: Rivera, María Teresa. Hospital del Salvador; ChileFil: Cortés, Analía. Hospital del Salvador; ChileFil: Loader, Denisse. Hospital Padre Hurtado; ChileFil: Saavedra, Javiera. Hospital Padre Hurtado; ChileFil: Gutiérrez, Lorena. Hospital San Juan de Dios; ChileFil: Ortega, Alejandro. Hospital Regional; ChileFil: Bertrán, Maria Enriqueta. Hospital Base de Valdivia; ChileFil: Bartolotti, Leonardo. Hospital Base de Valdivia; ChileFil: Gabler, Fernando. Hospital Clínico San Borja Arriarán; ChileFil: Campos, Mónica. Hospital Clínico San Borja Arriarán; ChileFil: Alvarado, Juan. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; ChileFil: Moisán, Fabricio. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; ChileFil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; ChileFil: Nervi, Bruno. No especifíca;Fil: Carvajal Hausdorf, Daniel. Universidad del Desarrollo; ChileFil: Losada, Héctor. Universidad de La Frontera; ChileFil: Almau, Mauricio. Hospital de Rancagua; ChileFil: Fernández, Plinio. Hospital de Rancagua; ChileFil: Olloquequi, Jordi. Universidad de Barcelona; EspañaFil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; ChileFil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; BrasilFil: Acuña Alonzo, Victor. No especifíca;Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Ruiz-Linares, Andres. Colegio Universitario de Londres; Reino UnidoFil: Rothhammer, Francisco. Universidad de Tarapacá; ChileFil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; AlemaniaJohn Wiley & Sons2023-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/214479Boekstegers, Felix; Scherer, Dominique; Barahona Ponce, Carol; Marcelain, Katherine; Gárate Calderón, Valentina; et al.; Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country; John Wiley & Sons; International Journal of Cancer. Journal International du Cancer; 153; 6; 7-2023; 1151-11610020-7136CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ijc.34607info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:51:07Zoai:ri.conicet.gov.ar:11336/214479instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:51:08.237CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| title |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| spellingShingle |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country Boekstegers, Felix CHOLECYSTECTOMY GALLBLADDER CANCER GALLSTONES NATIVE AMERICAN ANCESTRY NON-GENETIC AND GENETIC RISK FACTORS RISK PREDICTION |
| title_short |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| title_full |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| title_fullStr |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| title_full_unstemmed |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| title_sort |
Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country |
| dc.creator.none.fl_str_mv |
Boekstegers, Felix Scherer, Dominique Barahona Ponce, Carol Marcelain, Katherine Gárate Calderón, Valentina Waldenberger, Melanie Morales, Erik Rojas, Armando Munoz, César Retamales, Javier de Toro, Gonzalo Barajas, Olga Rivera, María Teresa Cortés, Analía Loader, Denisse Saavedra, Javiera Gutiérrez, Lorena Ortega, Alejandro Bertrán, Maria Enriqueta Bartolotti, Leonardo Gabler, Fernando Campos, Mónica Alvarado, Juan Moisán, Fabricio Spencer, Loreto Nervi, Bruno Carvajal Hausdorf, Daniel Losada, Héctor Almau, Mauricio Fernández, Plinio Olloquequi, Jordi Fuentes Guajardo, Macarena Gonzalez-Jose, Rolando Bortolini, Maria Cátira Acuña Alonzo, Victor Gallo, Carla Ruiz-Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author |
Boekstegers, Felix |
| author_facet |
Boekstegers, Felix Scherer, Dominique Barahona Ponce, Carol Marcelain, Katherine Gárate Calderón, Valentina Waldenberger, Melanie Morales, Erik Rojas, Armando Munoz, César Retamales, Javier de Toro, Gonzalo Barajas, Olga Rivera, María Teresa Cortés, Analía Loader, Denisse Saavedra, Javiera Gutiérrez, Lorena Ortega, Alejandro Bertrán, Maria Enriqueta Bartolotti, Leonardo Gabler, Fernando Campos, Mónica Alvarado, Juan Moisán, Fabricio Spencer, Loreto Nervi, Bruno Carvajal Hausdorf, Daniel Losada, Héctor Almau, Mauricio Fernández, Plinio Olloquequi, Jordi Fuentes Guajardo, Macarena Gonzalez-Jose, Rolando Bortolini, Maria Cátira Acuña Alonzo, Victor Gallo, Carla Ruiz-Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author_role |
author |
| author2 |
Scherer, Dominique Barahona Ponce, Carol Marcelain, Katherine Gárate Calderón, Valentina Waldenberger, Melanie Morales, Erik Rojas, Armando Munoz, César Retamales, Javier de Toro, Gonzalo Barajas, Olga Rivera, María Teresa Cortés, Analía Loader, Denisse Saavedra, Javiera Gutiérrez, Lorena Ortega, Alejandro Bertrán, Maria Enriqueta Bartolotti, Leonardo Gabler, Fernando Campos, Mónica Alvarado, Juan Moisán, Fabricio Spencer, Loreto Nervi, Bruno Carvajal Hausdorf, Daniel Losada, Héctor Almau, Mauricio Fernández, Plinio Olloquequi, Jordi Fuentes Guajardo, Macarena Gonzalez-Jose, Rolando Bortolini, Maria Cátira Acuña Alonzo, Victor Gallo, Carla Ruiz-Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CHOLECYSTECTOMY GALLBLADDER CANCER GALLSTONES NATIVE AMERICAN ANCESTRY NON-GENETIC AND GENETIC RISK FACTORS RISK PREDICTION |
| topic |
CHOLECYSTECTOMY GALLBLADDER CANCER GALLSTONES NATIVE AMERICAN ANCESTRY NON-GENETIC AND GENETIC RISK FACTORS RISK PREDICTION |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Since 2006, Chile has been implementing a gallbladder cancer (GBC) prevention program based on prophylactic cholecystectomy for gallstone patients aged 35 to 49 years. The effectiveness of this prevention program has not yet been comprehensively evaluated. We conducted a retrospective study of 473 Chilean GBC patients and 2137 population-based controls to develop and internally validate three GBC risk prediction models. The Baseline Model accounted for gallstones while adjusting for sex and birth year. Enhanced Model I also included the non-genetic risk factors: body mass index, educational level, Mapuche surnames, number of children and family history of GBC. Enhanced Model II further included Mapuche ancestry and the genotype for rs17209837. Multiple Cox regression was applied to assess the predictive performance, quantified by the area under the precision-recall curve (AUC-PRC) and the number of cholecystectomies needed (NCN) to prevent one case of GBC at age 70 years. The AUC-PRC for the Baseline Model (0.44%, 95%CI 0.42-0.46) increased by 0.22 (95%CI 0.15-0.29) when non-genetic factors were included, and by 0.25 (95%CI 0.20-0.30) when incorporating non-genetic and genetic factors. The overall NCN for Chileans with gallstones (115, 95%CI 104-131) decreased to 92 (95%CI 60-128) for Chileans with a higher risk than the median according to Enhanced Model I, and to 80 (95%CI 59-110) according to Enhanced Model II. In conclusion, age, sex and gallstones are strong risk factors for GBC, but consideration of other non-genetic factors and individual genotype data improves risk prediction and may optimize allocation of financial resources and surgical capacity. Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Marcelain, Katherine. Universidad de Chile; Chile Fil: Gárate Calderón, Valentina. Universidad de Chile; Chile Fil: Waldenberger, Melanie. No especifíca; Fil: Morales, Erik. Universidad Católica de Maule; Chile Fil: Rojas, Armando. Universidad Católica de Maule; Chile Fil: Munoz, César. Universidad Católica de Maule; Chile Fil: Retamales, Javier. Instituto Nacional del Cáncer; Chile Fil: de Toro, Gonzalo. Universidad Austral de Chile; Chile Fil: Barajas, Olga. Universidad de Chile; Chile Fil: Rivera, María Teresa. Hospital del Salvador; Chile Fil: Cortés, Analía. Hospital del Salvador; Chile Fil: Loader, Denisse. Hospital Padre Hurtado; Chile Fil: Saavedra, Javiera. Hospital Padre Hurtado; Chile Fil: Gutiérrez, Lorena. Hospital San Juan de Dios; Chile Fil: Ortega, Alejandro. Hospital Regional; Chile Fil: Bertrán, Maria Enriqueta. Hospital Base de Valdivia; Chile Fil: Bartolotti, Leonardo. Hospital Base de Valdivia; Chile Fil: Gabler, Fernando. Hospital Clínico San Borja Arriarán; Chile Fil: Campos, Mónica. Hospital Clínico San Borja Arriarán; Chile Fil: Alvarado, Juan. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile Fil: Moisán, Fabricio. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile Fil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile Fil: Nervi, Bruno. No especifíca; Fil: Carvajal Hausdorf, Daniel. Universidad del Desarrollo; Chile Fil: Losada, Héctor. Universidad de La Frontera; Chile Fil: Almau, Mauricio. Hospital de Rancagua; Chile Fil: Fernández, Plinio. Hospital de Rancagua; Chile Fil: Olloquequi, Jordi. Universidad de Barcelona; España Fil: Fuentes Guajardo, Macarena. Universidad de Tarapacá; Chile Fil: Gonzalez-Jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Bortolini, Maria Cátira. Universidade Federal do Rio Grande do Sul; Brasil Fil: Acuña Alonzo, Victor. No especifíca; Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Ruiz-Linares, Andres. Colegio Universitario de Londres; Reino Unido Fil: Rothhammer, Francisco. Universidad de Tarapacá; Chile Fil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; Alemania |
| description |
Since 2006, Chile has been implementing a gallbladder cancer (GBC) prevention program based on prophylactic cholecystectomy for gallstone patients aged 35 to 49 years. The effectiveness of this prevention program has not yet been comprehensively evaluated. We conducted a retrospective study of 473 Chilean GBC patients and 2137 population-based controls to develop and internally validate three GBC risk prediction models. The Baseline Model accounted for gallstones while adjusting for sex and birth year. Enhanced Model I also included the non-genetic risk factors: body mass index, educational level, Mapuche surnames, number of children and family history of GBC. Enhanced Model II further included Mapuche ancestry and the genotype for rs17209837. Multiple Cox regression was applied to assess the predictive performance, quantified by the area under the precision-recall curve (AUC-PRC) and the number of cholecystectomies needed (NCN) to prevent one case of GBC at age 70 years. The AUC-PRC for the Baseline Model (0.44%, 95%CI 0.42-0.46) increased by 0.22 (95%CI 0.15-0.29) when non-genetic factors were included, and by 0.25 (95%CI 0.20-0.30) when incorporating non-genetic and genetic factors. The overall NCN for Chileans with gallstones (115, 95%CI 104-131) decreased to 92 (95%CI 60-128) for Chileans with a higher risk than the median according to Enhanced Model I, and to 80 (95%CI 59-110) according to Enhanced Model II. In conclusion, age, sex and gallstones are strong risk factors for GBC, but consideration of other non-genetic factors and individual genotype data improves risk prediction and may optimize allocation of financial resources and surgical capacity. |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
| status_str |
publishedVersion |
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http://hdl.handle.net/11336/214479 Boekstegers, Felix; Scherer, Dominique; Barahona Ponce, Carol; Marcelain, Katherine; Gárate Calderón, Valentina; et al.; Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country; John Wiley & Sons; International Journal of Cancer. Journal International du Cancer; 153; 6; 7-2023; 1151-1161 0020-7136 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/214479 |
| identifier_str_mv |
Boekstegers, Felix; Scherer, Dominique; Barahona Ponce, Carol; Marcelain, Katherine; Gárate Calderón, Valentina; et al.; Development and internal validation of a multifactorial risk prediction model for gallbladder cancer in a high-incidence country; John Wiley & Sons; International Journal of Cancer. Journal International du Cancer; 153; 6; 7-2023; 1151-1161 0020-7136 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
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info:eu-repo/semantics/altIdentifier/doi/10.1002/ijc.34607 |
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openAccess |
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application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
John Wiley & Sons |
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John Wiley & Sons |
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reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
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dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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