ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans
- Autores
- Boekstegers, Felix; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; de Toro, Gonzalo; Retamales, Javier; Barajas, Olga; Ahumada, Monica; Morales, Erik; Rojas, Armando; Sanhueza, Verónica; Loader, Denisse; Rivera, María Teresa; Gutiérrez, Lorena; Bernal, Giuliano; Ortega, Alejandro; Montalvo, Domingo; Portiño, Sergio; Bertrán, Maria Enriqueta; Gabler, Fernando; Spencer, Loreto; Olloquequi, Jordi; González Silos, Rosa; Fischer, Christine; Scherer, Dominique; Jenab, Mazda; Aleksandrova, Krasimira; Katzke, Verena; Gonzalez-jose, Rolando; Weiderpass, Elisabete; Moradi, Tahereh; Fischer, Krista; Bossers, Willem; Brenner, Hermann; Hveem, Kristian; Eklund, Niina; Völker, Uwe; Waldenberger, Melanie; Fuentes Guajardo, Macarena; Bedoya, Gabriel; Bortolini, Maria C.; Canizales, Samuel; Gallo, Carla; Ruiz Linares, Andres; Rothhammer, Francisco; Lorenzo Bermejo, Justo
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.
Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Marcelain, Katherine. Universidad de Chile; Chile
Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile
Fil: Baez Benavides, Pablo F.. Universidad de Chile; Chile
Fil: Müller, Bettina. Instituto Nacional del Cáncer, Chile; Chile
Fil: de Toro, Gonzalo. Hospital Puerto Montt; Chile
Fil: Retamales, Javier. Instituto Nacional del Cáncer, Chile; Chile
Fil: Barajas, Olga. Hospital Clinico de la Universidad de Chile; Chile. Universidad de Chile; Chile
Fil: Ahumada, Monica. Hospital Clínico de la Universidad de Chile; Chile. Universidad de Chile; Chile
Fil: Morales, Erik. Regional Hospital; Chile
Fil: Rojas, Armando. Universidad Catolica de Maule; Chile
Fil: Sanhueza, Verónica. Hospital Padre Hurtado; Chile
Fil: Loader, Denisse. Hospital Padre Hurtado; Chile
Fil: Rivera, María Teresa. Hospital del Salvador; Chile
Fil: Gutiérrez, Lorena. Hospital San Juan de Dios, Santiago de Chile; Chile
Fil: Bernal, Giuliano. Universidad Católica del Norte; Chile
Fil: Ortega, Alejandro. Hospital Regional, Arica; Chile
Fil: Montalvo, Domingo. Hospital Regional de Arica Doctor Juan Noé Crevani; Chile
Fil: Portiño, Sergio. Hospital Clinico de la Universidad de Chile; Chile
Fil: Bertrán, Maria Enriqueta. Ministerio de Salud, Valdivia; Chile
Fil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile
Fil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile
Fil: Olloquequi, Jordi. Universidad Autónoma de Chile; Chile
Fil: González Silos, Rosa. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania
Fil: Jenab, Mazda. International Agency for Research on Cancer; Francia
Fil: Aleksandrova, Krasimira. Universitat Potsdam; Alemania
Fil: Katzke, Verena. German Cancer Research Center; Alemania
Fil: Gonzalez-jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina
Fil: Weiderpass, Elisabete. International Agency for Research on Cancer; Francia
Fil: Moradi, Tahereh. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Fischer, Krista. University of Tartu; Estonia
Fil: Bossers, Willem. Lifelines Cohort Study; Países Bajos
Fil: Brenner, Hermann. German Cancer Research Center; Alemania
Fil: Hveem, Kristian. Norges Teknisk naturvitenskapelige Universitet; Noruega
Fil: Eklund, Niina. National Institute For Health And Welfare; Finlandia
Fil: Völker, Uwe. Universitätsmedizin Greifswald; Alemania
Fil: Waldenberger, Melanie. Helmholtz Center Munich German Research Center For Environmental Health; Alemania
Fil: Fuentes Guajardo, Macarena. Universidad de Tarapaca.; Chile
Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia
Fil: Bortolini, Maria C.. Universidade Federal do Rio Grande do Sul; Brasil
Fil: Canizales, Samuel. Universidad Nacional Autónoma de México; México
Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú
Fil: Ruiz Linares, Andres. Fudan University; China
Fil: Rothhammer, Francisco. Universidad de Tarapaca.; Chile
Fil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; Alemania - Materia
-
CANCER EPIDEMIOLOGY
GALLBLADDER CANCER
NATIVE AMERICAN ANCESTRY
POPULATION-SPECIFIC RISK MARKER - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/125842
Ver los metadatos del registro completo
| id |
CONICETDig_254e0d7623cd8da8924ca5524518364f |
|---|---|
| oai_identifier_str |
oai:ri.conicet.gov.ar:11336/125842 |
| network_acronym_str |
CONICETDig |
| repository_id_str |
3498 |
| network_name_str |
CONICET Digital (CONICET) |
| spelling |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in ChileansBoekstegers, FelixMarcelain, KatherineBarahona Ponce, CarolBaez Benavides, Pablo F.Müller, Bettinade Toro, GonzaloRetamales, JavierBarajas, OlgaAhumada, MonicaMorales, ErikRojas, ArmandoSanhueza, VerónicaLoader, DenisseRivera, María TeresaGutiérrez, LorenaBernal, GiulianoOrtega, AlejandroMontalvo, DomingoPortiño, SergioBertrán, Maria EnriquetaGabler, FernandoSpencer, LoretoOlloquequi, JordiGonzález Silos, RosaFischer, ChristineScherer, DominiqueJenab, MazdaAleksandrova, KrasimiraKatzke, VerenaGonzalez-jose, RolandoWeiderpass, ElisabeteMoradi, TaherehFischer, KristaBossers, WillemBrenner, HermannHveem, KristianEklund, NiinaVölker, UweWaldenberger, MelanieFuentes Guajardo, MacarenaBedoya, GabrielBortolini, Maria C.Canizales, SamuelGallo, CarlaRuiz Linares, AndresRothhammer, FranciscoLorenzo Bermejo, JustoCANCER EPIDEMIOLOGYGALLBLADDER CANCERNATIVE AMERICAN ANCESTRYPOPULATION-SPECIFIC RISK MARKERhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Marcelain, Katherine. Universidad de Chile; ChileFil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; ChileFil: Baez Benavides, Pablo F.. Universidad de Chile; ChileFil: Müller, Bettina. Instituto Nacional del Cáncer, Chile; ChileFil: de Toro, Gonzalo. Hospital Puerto Montt; ChileFil: Retamales, Javier. Instituto Nacional del Cáncer, Chile; ChileFil: Barajas, Olga. Hospital Clinico de la Universidad de Chile; Chile. Universidad de Chile; ChileFil: Ahumada, Monica. Hospital Clínico de la Universidad de Chile; Chile. Universidad de Chile; ChileFil: Morales, Erik. Regional Hospital; ChileFil: Rojas, Armando. Universidad Catolica de Maule; ChileFil: Sanhueza, Verónica. Hospital Padre Hurtado; ChileFil: Loader, Denisse. Hospital Padre Hurtado; ChileFil: Rivera, María Teresa. Hospital del Salvador; ChileFil: Gutiérrez, Lorena. Hospital San Juan de Dios, Santiago de Chile; ChileFil: Bernal, Giuliano. Universidad Católica del Norte; ChileFil: Ortega, Alejandro. Hospital Regional, Arica; ChileFil: Montalvo, Domingo. Hospital Regional de Arica Doctor Juan Noé Crevani; ChileFil: Portiño, Sergio. Hospital Clinico de la Universidad de Chile; ChileFil: Bertrán, Maria Enriqueta. Ministerio de Salud, Valdivia; ChileFil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; ChileFil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; ChileFil: Olloquequi, Jordi. Universidad Autónoma de Chile; ChileFil: González Silos, Rosa. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; AlemaniaFil: Jenab, Mazda. International Agency for Research on Cancer; FranciaFil: Aleksandrova, Krasimira. Universitat Potsdam; AlemaniaFil: Katzke, Verena. German Cancer Research Center; AlemaniaFil: Gonzalez-jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; ArgentinaFil: Weiderpass, Elisabete. International Agency for Research on Cancer; FranciaFil: Moradi, Tahereh. Karolinska Huddinge Hospital. Karolinska Institutet; SueciaFil: Fischer, Krista. University of Tartu; EstoniaFil: Bossers, Willem. Lifelines Cohort Study; Países BajosFil: Brenner, Hermann. German Cancer Research Center; AlemaniaFil: Hveem, Kristian. Norges Teknisk naturvitenskapelige Universitet; NoruegaFil: Eklund, Niina. National Institute For Health And Welfare; FinlandiaFil: Völker, Uwe. Universitätsmedizin Greifswald; AlemaniaFil: Waldenberger, Melanie. Helmholtz Center Munich German Research Center For Environmental Health; AlemaniaFil: Fuentes Guajardo, Macarena. Universidad de Tarapaca.; ChileFil: Bedoya, Gabriel. Universidad de Antioquia; ColombiaFil: Bortolini, Maria C.. Universidade Federal do Rio Grande do Sul; BrasilFil: Canizales, Samuel. Universidad Nacional Autónoma de México; MéxicoFil: Gallo, Carla. Universidad Peruana Cayetano Heredia; PerúFil: Ruiz Linares, Andres. Fudan University; ChinaFil: Rothhammer, Francisco. Universidad de Tarapaca.; ChileFil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; AlemaniaElsevier2020-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/125842Boekstegers, Felix; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; et al.; ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans; Elsevier; Cancer Epidemiology; 65; 4-20201877-7821CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.canep.2019.101643info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1877782119301535?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:53Zoai:ri.conicet.gov.ar:11336/125842instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:53.627CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| title |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| spellingShingle |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans Boekstegers, Felix CANCER EPIDEMIOLOGY GALLBLADDER CANCER NATIVE AMERICAN ANCESTRY POPULATION-SPECIFIC RISK MARKER |
| title_short |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| title_full |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| title_fullStr |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| title_full_unstemmed |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| title_sort |
ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans |
| dc.creator.none.fl_str_mv |
Boekstegers, Felix Marcelain, Katherine Barahona Ponce, Carol Baez Benavides, Pablo F. Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi González Silos, Rosa Fischer, Christine Scherer, Dominique Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-jose, Rolando Weiderpass, Elisabete Moradi, Tahereh Fischer, Krista Bossers, Willem Brenner, Hermann Hveem, Kristian Eklund, Niina Völker, Uwe Waldenberger, Melanie Fuentes Guajardo, Macarena Bedoya, Gabriel Bortolini, Maria C. Canizales, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author |
Boekstegers, Felix |
| author_facet |
Boekstegers, Felix Marcelain, Katherine Barahona Ponce, Carol Baez Benavides, Pablo F. Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi González Silos, Rosa Fischer, Christine Scherer, Dominique Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-jose, Rolando Weiderpass, Elisabete Moradi, Tahereh Fischer, Krista Bossers, Willem Brenner, Hermann Hveem, Kristian Eklund, Niina Völker, Uwe Waldenberger, Melanie Fuentes Guajardo, Macarena Bedoya, Gabriel Bortolini, Maria C. Canizales, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author_role |
author |
| author2 |
Marcelain, Katherine Barahona Ponce, Carol Baez Benavides, Pablo F. Müller, Bettina de Toro, Gonzalo Retamales, Javier Barajas, Olga Ahumada, Monica Morales, Erik Rojas, Armando Sanhueza, Verónica Loader, Denisse Rivera, María Teresa Gutiérrez, Lorena Bernal, Giuliano Ortega, Alejandro Montalvo, Domingo Portiño, Sergio Bertrán, Maria Enriqueta Gabler, Fernando Spencer, Loreto Olloquequi, Jordi González Silos, Rosa Fischer, Christine Scherer, Dominique Jenab, Mazda Aleksandrova, Krasimira Katzke, Verena Gonzalez-jose, Rolando Weiderpass, Elisabete Moradi, Tahereh Fischer, Krista Bossers, Willem Brenner, Hermann Hveem, Kristian Eklund, Niina Völker, Uwe Waldenberger, Melanie Fuentes Guajardo, Macarena Bedoya, Gabriel Bortolini, Maria C. Canizales, Samuel Gallo, Carla Ruiz Linares, Andres Rothhammer, Francisco Lorenzo Bermejo, Justo |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
CANCER EPIDEMIOLOGY GALLBLADDER CANCER NATIVE AMERICAN ANCESTRY POPULATION-SPECIFIC RISK MARKER |
| topic |
CANCER EPIDEMIOLOGY GALLBLADDER CANCER NATIVE AMERICAN ANCESTRY POPULATION-SPECIFIC RISK MARKER |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| dc.description.none.fl_txt_mv |
Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. Fil: Boekstegers, Felix. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Marcelain, Katherine. Universidad de Chile; Chile Fil: Barahona Ponce, Carol. Ruprecht Karls Universitat Heidelberg; Alemania. Universidad de Chile; Chile Fil: Baez Benavides, Pablo F.. Universidad de Chile; Chile Fil: Müller, Bettina. Instituto Nacional del Cáncer, Chile; Chile Fil: de Toro, Gonzalo. Hospital Puerto Montt; Chile Fil: Retamales, Javier. Instituto Nacional del Cáncer, Chile; Chile Fil: Barajas, Olga. Hospital Clinico de la Universidad de Chile; Chile. Universidad de Chile; Chile Fil: Ahumada, Monica. Hospital Clínico de la Universidad de Chile; Chile. Universidad de Chile; Chile Fil: Morales, Erik. Regional Hospital; Chile Fil: Rojas, Armando. Universidad Catolica de Maule; Chile Fil: Sanhueza, Verónica. Hospital Padre Hurtado; Chile Fil: Loader, Denisse. Hospital Padre Hurtado; Chile Fil: Rivera, María Teresa. Hospital del Salvador; Chile Fil: Gutiérrez, Lorena. Hospital San Juan de Dios, Santiago de Chile; Chile Fil: Bernal, Giuliano. Universidad Católica del Norte; Chile Fil: Ortega, Alejandro. Hospital Regional, Arica; Chile Fil: Montalvo, Domingo. Hospital Regional de Arica Doctor Juan Noé Crevani; Chile Fil: Portiño, Sergio. Hospital Clinico de la Universidad de Chile; Chile Fil: Bertrán, Maria Enriqueta. Ministerio de Salud, Valdivia; Chile Fil: Gabler, Fernando. Universidad de Santiago de Chile. Hospital Clinico San Borja Arriaran; Chile Fil: Spencer, Loreto. Hospital Regional de Concepción - Dr. Guillermo Grant Benavente; Chile Fil: Olloquequi, Jordi. Universidad Autónoma de Chile; Chile Fil: González Silos, Rosa. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Fischer, Christine. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Scherer, Dominique. Ruprecht Karls Universitat Heidelberg; Alemania Fil: Jenab, Mazda. International Agency for Research on Cancer; Francia Fil: Aleksandrova, Krasimira. Universitat Potsdam; Alemania Fil: Katzke, Verena. German Cancer Research Center; Alemania Fil: Gonzalez-jose, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico de Ciencias Sociales y Humanas; Argentina Fil: Weiderpass, Elisabete. International Agency for Research on Cancer; Francia Fil: Moradi, Tahereh. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia Fil: Fischer, Krista. University of Tartu; Estonia Fil: Bossers, Willem. Lifelines Cohort Study; Países Bajos Fil: Brenner, Hermann. German Cancer Research Center; Alemania Fil: Hveem, Kristian. Norges Teknisk naturvitenskapelige Universitet; Noruega Fil: Eklund, Niina. National Institute For Health And Welfare; Finlandia Fil: Völker, Uwe. Universitätsmedizin Greifswald; Alemania Fil: Waldenberger, Melanie. Helmholtz Center Munich German Research Center For Environmental Health; Alemania Fil: Fuentes Guajardo, Macarena. Universidad de Tarapaca.; Chile Fil: Bedoya, Gabriel. Universidad de Antioquia; Colombia Fil: Bortolini, Maria C.. Universidade Federal do Rio Grande do Sul; Brasil Fil: Canizales, Samuel. Universidad Nacional Autónoma de México; México Fil: Gallo, Carla. Universidad Peruana Cayetano Heredia; Perú Fil: Ruiz Linares, Andres. Fudan University; China Fil: Rothhammer, Francisco. Universidad de Tarapaca.; Chile Fil: Lorenzo Bermejo, Justo. Ruprecht Karls Universitat Heidelberg; Alemania |
| description |
Background: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-04 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/125842 Boekstegers, Felix; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; et al.; ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans; Elsevier; Cancer Epidemiology; 65; 4-2020 1877-7821 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/125842 |
| identifier_str_mv |
Boekstegers, Felix; Marcelain, Katherine; Barahona Ponce, Carol; Baez Benavides, Pablo F.; Müller, Bettina; et al.; ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans; Elsevier; Cancer Epidemiology; 65; 4-2020 1877-7821 CONICET Digital CONICET |
| dc.language.none.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.canep.2019.101643 info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S1877782119301535?via%3Dihub |
| dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
| eu_rights_str_mv |
openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
| dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
| dc.publisher.none.fl_str_mv |
Elsevier |
| publisher.none.fl_str_mv |
Elsevier |
| dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
| reponame_str |
CONICET Digital (CONICET) |
| collection |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
| repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
| _version_ |
1842269933069664256 |
| score |
13.13397 |