Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate rele...

Autores
Ferrero, Alejandro Javier; Cereseto, Marina; Reines, Analia Gabriela; Bonavita, Carla D.; Sifonios, Laura Lucrecia; Rubio, Modesto Carlos; Wikinski, Silvia Ines
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.
Fil: Carabajal Ferrero, Claudio Marcelo. Hospital Italiano; Argentina
Fil: Cereseto, Marina. ININFA; Argentina
Fil: Reines, Analia Gabriela. ININFA; Argentina
Fil: Bonavita, Liliana Noemi. NINFA; Argentina
Fil: Sifonios, Laura Lucrecia. ININFA; Argentina
Fil: Rubio, Modesto Carlos. ININFA; Argentina
Fil: Wikinski, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. ININFA; Argentina
Materia
CHRONIC TREATMENT
FLUOXETINE
GLUTAMATE RELEASE
HIPPOCAMPUS
LEARNED HELPLESSNESS
SEIZURE THRESHOLD
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/94572
Acceder
id CONICETDig_93e7ab8624d533f2740d3ff34fb93850
oai_identifier_str oai:ri.conicet.gov.ar:11336/94572
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate releaseFerrero, Alejandro JavierCereseto, MarinaReines, Analia GabrielaBonavita, Carla D.Sifonios, Laura LucreciaRubio, Modesto CarlosWikinski, Silvia InesCHRONIC TREATMENTFLUOXETINEGLUTAMATE RELEASEHIPPOCAMPUSLEARNED HELPLESSNESSSEIZURE THRESHOLDhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.Fil: Carabajal Ferrero, Claudio Marcelo. Hospital Italiano; ArgentinaFil: Cereseto, Marina. ININFA; ArgentinaFil: Reines, Analia Gabriela. ININFA; ArgentinaFil: Bonavita, Liliana Noemi. NINFA; ArgentinaFil: Sifonios, Laura Lucrecia. ININFA; ArgentinaFil: Rubio, Modesto Carlos. ININFA; ArgentinaFil: Wikinski, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. ININFA; ArgentinaPergamon-Elsevier Science Ltd2005-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/94572Ferrero, Alejandro Javier; Cereseto, Marina; Reines, Analia Gabriela; Bonavita, Carla D.; Sifonios, Laura Lucrecia; et al.; Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 29; 5; 6-2005; 678-6860278-5846CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278584605001326info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2005.04.013info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:45Zoai:ri.conicet.gov.ar:11336/94572instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:45.8CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
title Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
spellingShingle Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
Ferrero, Alejandro Javier
CHRONIC TREATMENT
FLUOXETINE
GLUTAMATE RELEASE
HIPPOCAMPUS
LEARNED HELPLESSNESS
SEIZURE THRESHOLD
title_short Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
title_full Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
title_fullStr Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
title_full_unstemmed Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
title_sort Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release
dc.creator.none.fl_str_mv Ferrero, Alejandro Javier
Cereseto, Marina
Reines, Analia Gabriela
Bonavita, Carla D.
Sifonios, Laura Lucrecia
Rubio, Modesto Carlos
Wikinski, Silvia Ines
author Ferrero, Alejandro Javier
author_facet Ferrero, Alejandro Javier
Cereseto, Marina
Reines, Analia Gabriela
Bonavita, Carla D.
Sifonios, Laura Lucrecia
Rubio, Modesto Carlos
Wikinski, Silvia Ines
author_role author
author2 Cereseto, Marina
Reines, Analia Gabriela
Bonavita, Carla D.
Sifonios, Laura Lucrecia
Rubio, Modesto Carlos
Wikinski, Silvia Ines
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CHRONIC TREATMENT
FLUOXETINE
GLUTAMATE RELEASE
HIPPOCAMPUS
LEARNED HELPLESSNESS
SEIZURE THRESHOLD
topic CHRONIC TREATMENT
FLUOXETINE
GLUTAMATE RELEASE
HIPPOCAMPUS
LEARNED HELPLESSNESS
SEIZURE THRESHOLD
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.
Fil: Carabajal Ferrero, Claudio Marcelo. Hospital Italiano; Argentina
Fil: Cereseto, Marina. ININFA; Argentina
Fil: Reines, Analia Gabriela. ININFA; Argentina
Fil: Bonavita, Liliana Noemi. NINFA; Argentina
Fil: Sifonios, Laura Lucrecia. ININFA; Argentina
Fil: Rubio, Modesto Carlos. ININFA; Argentina
Fil: Wikinski, Silvia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Farmacológicas. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Investigaciones Farmacológicas; Argentina. ININFA; Argentina
description The proconvulsive effect of the new generation of antidepressants remains controversial. The authors investigated in naïve rats the effect of chronic treatment with fluoxetine (FLX) on the convulsive threshold and on two parameters of the hippocampal glutamatergic neurotransmission: the in vitro glutamate release and the binding of [3H] MK801 to NMDA receptors. While the acute treatment with FLX provoked no change either in seizure susceptibility or in the glutamate release, the chronic treatment decreased the convulsive threshold in coincidence with an increment in the in vitro glutamate release. No significant effects on the binding of [3H] MK801 to NMDA receptors were found to be attributable to the FLX treatment. We also assessed the effect of the chronic treatment with FLX on the seizure threshold in rats exposed to an experimental model of depression, the learned helplessness paradigm (LH). While a decrease in the K+-stimulated glutamate release was observed in non treated LH animals, when they were chronically injected with FLX, no changes in the epileptic susceptibility and no increments in the glutamate release were found. Our results indicate that chronic treatment with FLX decreases the epileptic threshold in naïve but not in LH rats and that this effect correlates with the levels of the hippocampal glutamate release.
publishDate 2005
dc.date.none.fl_str_mv 2005-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/94572
Ferrero, Alejandro Javier; Cereseto, Marina; Reines, Analia Gabriela; Bonavita, Carla D.; Sifonios, Laura Lucrecia; et al.; Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 29; 5; 6-2005; 678-686
0278-5846
CONICET Digital
CONICET
url http://hdl.handle.net/11336/94572
identifier_str_mv Ferrero, Alejandro Javier; Cereseto, Marina; Reines, Analia Gabriela; Bonavita, Carla D.; Sifonios, Laura Lucrecia; et al.; Chronic treatment with fluoxetine decreases seizure threshold in naïve but not in rats exposed to the learned helplessness paradigm: Correlation with the hippocampal glutamate release; Pergamon-Elsevier Science Ltd; Progress of Neuro-psychopharmacology and Biological Psychiatry; 29; 5; 6-2005; 678-686
0278-5846
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0278584605001326
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2005.04.013
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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