Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100

Autores
Quinteros, Daniela Alejandra; Allemandi, Daniel Alberto; Manzo, Ruben Hilario
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Abstract Equilibria and release properties of aqueous systems consisting of a set of five non steroidal antiinflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A- and Cl-) produces clear stable aqueous dispersions in which a remarcable high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes towards a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behave as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.
Fil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
AINES
Liberacion controlada de fármacos
Eudragit E100
Complejos Polielectrolito- Farmaco
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/195983
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/195983
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100Quinteros, Daniela AlejandraAllemandi, Daniel AlbertoManzo, Ruben HilarioAINESLiberacion controlada de fármacosEudragit E100Complejos Polielectrolito- Farmacohttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Abstract Equilibria and release properties of aqueous systems consisting of a set of five non steroidal antiinflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A- and Cl-) produces clear stable aqueous dispersions in which a remarcable high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes towards a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behave as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.Fil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaÖsterreichische Pharmazeutische Gesellschaft2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/195983Quinteros, Daniela Alejandra; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100; Österreichische Pharmazeutische Gesellschaft; Scientia Pharmaceutica; 80; 4-2012; 487-4962218-0532CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-0532/80/2/487info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:08:52Zoai:ri.conicet.gov.ar:11336/195983instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:08:53.119CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
title Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
spellingShingle Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
Quinteros, Daniela Alejandra
AINES
Liberacion controlada de fármacos
Eudragit E100
Complejos Polielectrolito- Farmaco
title_short Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
title_full Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
title_fullStr Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
title_full_unstemmed Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
title_sort Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100
dc.creator.none.fl_str_mv Quinteros, Daniela Alejandra
Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author Quinteros, Daniela Alejandra
author_facet Quinteros, Daniela Alejandra
Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author_role author
author2 Allemandi, Daniel Alberto
Manzo, Ruben Hilario
author2_role author
author
dc.subject.none.fl_str_mv AINES
Liberacion controlada de fármacos
Eudragit E100
Complejos Polielectrolito- Farmaco
topic AINES
Liberacion controlada de fármacos
Eudragit E100
Complejos Polielectrolito- Farmaco
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Abstract Equilibria and release properties of aqueous systems consisting of a set of five non steroidal antiinflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A- and Cl-) produces clear stable aqueous dispersions in which a remarcable high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes towards a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behave as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.
Fil: Quinteros, Daniela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Allemandi, Daniel Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Manzo, Ruben Hilario. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Abstract Equilibria and release properties of aqueous systems consisting of a set of five non steroidal antiinflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A- and Cl-) produces clear stable aqueous dispersions in which a remarcable high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes towards a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behave as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/195983
Quinteros, Daniela Alejandra; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100; Österreichische Pharmazeutische Gesellschaft; Scientia Pharmaceutica; 80; 4-2012; 487-496
2218-0532
CONICET Digital
CONICET
url http://hdl.handle.net/11336/195983
identifier_str_mv Quinteros, Daniela Alejandra; Allemandi, Daniel Alberto; Manzo, Ruben Hilario; Equilibrium and release properties of aqueous dispersions of non steroidal antiinflammatory drugs complexed with Polyelectrolyte Eudragit E 100; Österreichische Pharmazeutische Gesellschaft; Scientia Pharmaceutica; 80; 4-2012; 487-496
2218-0532
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2218-0532/80/2/487
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Österreichische Pharmazeutische Gesellschaft
publisher.none.fl_str_mv Österreichische Pharmazeutische Gesellschaft
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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